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ENZYME entry: EC

Accepted Name
protein-fructosamine 3-kinase.
Alternative Name(s)
fructosamine 3-kinase.
Reaction catalysed
ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]
  • Nonenzymatic glycation is an important factor in the pathogenesis of diabetic complications.
  • Key early intermediates in this process are fructosamines, such as [protein]-N(6)-D-fructosyl-L-lysine.
  • Fructosamine-3-kinase is part of an ATP-dependent system for removing carbohydrates from nonenzymatically glycated proteins.
  • The phosphorylation destablilizes the [protein]-N(6)-D-fructosyl-L- lysine adduct and leads to its spontaneous decomposition.
  • Cf. EC
PRIAM enzyme-specific profiles2.7.1.171
KEGG Ligand Database for Enzyme Nomenclature2.7.1.171
IUBMB Enzyme Nomenclature2.7.1.171
MEDLINEFind literature relating to
Rhea expert-curated reactions2.7.1.171
Q9H479, FN3K_HUMAN;  Q9ER35, FN3K_MOUSE;  

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