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ENZYME entry: EC 2.7.1.171

Accepted Name
Protein-fructosamine 3-kinase.
Alternative Name(s)
Fructosamine 3-kinase.
Reaction catalysed
ATP + [protein]-N(6)-D-fructosyl-L-lysine <=> ADP + [protein]-N(6)-(3-O-phospho-D-fructosyl)-L-lysine
Comment(s)
  • Nonenzymatic glycation is an important factor in the pathogenesis of diabetic complications.
  • Key early intermediates in this process are fructosamines, such as [protein]-N(6)-D-fructosyl-L-lysine.
  • Fructosamine-3-kinase is part of an ATP-dependent system for removing carbohydrates from nonenzymatically glycated proteins.
  • The phosphorylation destablilizes the [protein]-N(6)-D-fructosyl-L- lysine adduct and leads to its spontaneous decomposition.
  • Cf. EC 2.7.1.172.
Cross-references
BRENDA2.7.1.171
EC2PDB2.7.1.171
ExplorEnz2.7.1.171
PRIAM enzyme-specific profiles2.7.1.171
KEGG Ligand Database for Enzyme Nomenclature2.7.1.171
IUBMB Enzyme Nomenclature2.7.1.171
IntEnz2.7.1.171
MEDLINEFind literature relating to 2.7.1.171
MetaCyc2.7.1.171
UniProtKB/Swiss-Prot
Q9H479, FN3K_HUMAN;  Q9ER35, FN3K_MOUSE;  

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