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ENZYME entry: EC 2.7.1.181
Accepted Name |
polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase.
|
Reaction catalysed |
alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP <=> 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+) |
Comment(s) |
- The enzyme is involved in the biosynthesis of the polymannose
O-polysaccharide in the outer leaflet of the membrane of Escherichia
coli serotype O9a.
- O-polysaccharide structures vary extensively because of differences
in the number and type of sugars in the repeat unit.
- The dual kinase/methylase WbdD also catalyzes the methylation of
3-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-
alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]n-alpha-D-
Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-
diphospho-ditrans,octacis-undecaprenol (Cf. EC 2.1.1.294).
|
Cross-references |
BRENDA | 2.7.1.181 |
EC2PDB | 2.7.1.181 |
ExplorEnz | 2.7.1.181 |
PRIAM enzyme-specific profiles | 2.7.1.181 |
KEGG Ligand Database for Enzyme Nomenclature | 2.7.1.181 |
IUBMB Enzyme Nomenclature | 2.7.1.181 |
IntEnz | 2.7.1.181 |
MEDLINE | Find literature relating to 2.7.1.181 |
MetaCyc | 2.7.1.181 |
Rhea expert-curated reactions | 2.7.1.181 |
UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
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