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ENZYME entry: EC 2.7.1.181

Accepted Name
polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase.
Reaction catalysed
alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP <=> 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+)
Comment(s)
  • The enzyme is involved in the biosynthesis of the polymannose O-polysaccharide in the outer leaflet of the membrane of Escherichia coli serotype O9a.
  • O-polysaccharide structures vary extensively because of differences in the number and type of sugars in the repeat unit.
  • The dual kinase/methylase WbdD also catalyzes the methylation of 3-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)- alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]n-alpha-D- Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc- diphospho-ditrans,octacis-undecaprenol (Cf. EC 2.1.1.294).
Cross-references
BRENDA2.7.1.181
EC2PDB2.7.1.181
ExplorEnz2.7.1.181
PRIAM enzyme-specific profiles2.7.1.181
KEGG Ligand Database for Enzyme Nomenclature2.7.1.181
IUBMB Enzyme Nomenclature2.7.1.181
IntEnz2.7.1.181
MEDLINEFind literature relating to 2.7.1.181
MetaCyc2.7.1.181
Rhea expert-curated reactions2.7.1.181
UniProtKB/Swiss-Prot
Q47592, WBDD2_ECOLX;  J7I4B7, WBDD_ECOLX;  

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