ENZYME entry: EC 2.1.1.294
Accepted Name |
3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol
3-phospho-methyltransferase.
|
Reaction catalysed |
S-adenosyl-L-methionine + 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2))(N)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol <=> S-adenosyl-L-homocysteine + 3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2))(N)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol |
Comment(s) |
- The enzyme is involved in the biosynthesis of the polymannose
O-polysaccharide in the outer leaflet of the membrane of Escherichia
coli serotype O9a.
- O-polysaccharide structures vary extensively because of differences
in the number and type of sugars in the repeat unit.
- The dual kinase/methylase WbdD also catalyzes the preceding
phosphorylation of alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-(alpha-D-
Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-
(1->2))(N)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-
alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol (cf.
EC 2.7.1.181).
|
Cross-references |
BRENDA | 2.1.1.294 |
EC2PDB | 2.1.1.294 |
ExplorEnz | 2.1.1.294 |
PRIAM enzyme-specific profiles | 2.1.1.294 |
KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.294 |
IUBMB Enzyme Nomenclature | 2.1.1.294 |
IntEnz | 2.1.1.294 |
MEDLINE | Find literature relating to 2.1.1.294 |
MetaCyc | 2.1.1.294 |
Rhea expert-curated reactions | 2.1.1.294 |
UniProtKB/Swiss-Prot |
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