ENZYME entry: EC 2.1.1.294
| Accepted Name |
|---|
| 3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol
3-phospho-methyltransferase.
|
| Reaction catalysed |
|---|
| S-adenosyl-L-methionine + 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2))(N)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol <=> S-adenosyl-L-homocysteine + 3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2))(N)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol |
| Comment(s) |
|---|
- The enzyme is involved in the biosynthesis of the polymannose
O-polysaccharide in the outer leaflet of the membrane of Escherichia
coli serotype O9a.
- O-polysaccharide structures vary extensively because of differences
in the number and type of sugars in the repeat unit.
- The dual kinase/methylase WbdD also catalyzes the preceding
phosphorylation of alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-(alpha-D-
Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-
(1->2))(N)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-
alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol (cf.
EC 2.7.1.181).
|
| Cross-references |
|---|
| BRENDA | 2.1.1.294 |
| EC2PDB | 2.1.1.294 |
| ExplorEnz | 2.1.1.294 |
| PRIAM enzyme-specific profiles | 2.1.1.294 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.294 |
| IUBMB Enzyme Nomenclature | 2.1.1.294 |
| IntEnz | 2.1.1.294 |
| MEDLINE | Find literature relating to 2.1.1.294 |
| MetaCyc | 2.1.1.294 |
| UniProtKB/Swiss-Prot |
|
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