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ENZYME entry: EC 2.7.1.190
Accepted Name |
aminoglycoside 2''-phosphotransferase.
|
Alternative Name(s) |
aminoglycoside (2'') kinase. |
APH(2''). |
gentamicin kinase. |
gentamicin phosphotransferase. |
Reaction catalysed |
a gentamycin + GTP <=> a gentamycin 2''-phosphate + GDP + H(+) |
Comment(s) |
- This bacterial enzyme phosphorylates many 4,6-disubstituted
aminoglycoside antibiotics that have a hydroxyl group at position
2'', including kanamycin A, kanamycin B, tobramycin, dibekacin,
arbekacin, amikacin, gentamicin C, sisomicin and netilmicin.
- In most, but not all, cases the phosphorylation confers resistance
against the antibiotic.
- Some forms of the enzyme use ATP as a phosphate donor in appreciable
amount.
- The enzyme is often found as a bifunctional enzyme that also
catalyzes 6'-aminoglycoside N-acetyltransferase activity.
- The bifunctional enzyme is the most clinically important
aminoglycoside-modifying enzyme in Gram-positive bacteria,
responsible for high-level resistance in both Enterococci and
Staphylococci.
|
Cross-references |
BRENDA | 2.7.1.190 |
EC2PDB | 2.7.1.190 |
ExplorEnz | 2.7.1.190 |
PRIAM enzyme-specific profiles | 2.7.1.190 |
KEGG Ligand Database for Enzyme Nomenclature | 2.7.1.190 |
IUBMB Enzyme Nomenclature | 2.7.1.190 |
IntEnz | 2.7.1.190 |
MEDLINE | Find literature relating to 2.7.1.190 |
MetaCyc | 2.7.1.190 |
Rhea expert-curated reactions | 2.7.1.190 |
UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
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