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ENZYME entry: EC 2.7.1.191

Accepted Name
Protein-N(pi)-phosphohistidine--D-mannose phosphotransferase.
Alternative Name(s)
Mannose PTS permease.
Reaction catalysed
[Protein]-N(pi)-phospho-L-histidine + D-mannose(Side 1) <=> [protein]-L-histidine + D-mannose 6-phosphate(Side 2)
Comment(s)
  • This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS).
  • The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it.
  • The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9.
  • Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency.
  • The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
  • Formerly EC 2.7.1.69.
Cross-references
PROSITEPDOC00795
BRENDA2.7.1.191
EC2PDB2.7.1.191
ExplorEnz2.7.1.191
PRIAM enzyme-specific profiles2.7.1.191
KEGG Ligand Database for Enzyme Nomenclature2.7.1.191
IUBMB Enzyme Nomenclature2.7.1.191
IntEnz2.7.1.191
MEDLINEFind literature relating to 2.7.1.191
MetaCyc2.7.1.191
UniProtKB/Swiss-Prot
O31644, MANR_BACSU;  O31645, PTN3B_BACSU;  Q46072, PTN3B_CORGL;  
P69799, PTNAB_ECO57;  P69798, PTNAB_ECOL6;  P69797, PTNAB_ECOLI;  
P69800, PTNAB_SHIFL;  Q5XAF5, PTNAB_STRP6;  

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