ENZYME entry: EC 2.7.1.192
Accepted Name |
protein-N(pi)-phosphohistidine--N-acetylmuramate phosphotransferase.
|
Alternative Name(s) |
N-acetylmuramic acid PTS permease. |
Reaction catalysed |
N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out) <=> L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in) |
Comment(s) |
- This enzyme is a component (known as enzyme II) of a
phosphoenolpyruvate (PEP)-dependent, sugar transporting
phosphotransferase system (PTS).
- The system, which is found only in prokaryotes, simultaneously
transports its substrate from the periplasm or extracellular space
into the cytoplasm and phosphorylates it.
- The phosphate donor, which is shared among the different systems,
is a phospho-carrier protein of low molecular mass that has been
phosphorylated by EC 2.7.3.9.
- Enzyme II, on the other hand, is specific for a particular substrate,
although in some cases alternative substrates can be transported with
lower efficiency.
- The reaction involves a successive transfer of the phosphate group to
several amino acids within the enzyme before the final transfer to
the substrate.
- Formerly EC 2.7.1.69.
|
Cross-references |
BRENDA | 2.7.1.192 |
EC2PDB | 2.7.1.192 |
ExplorEnz | 2.7.1.192 |
PRIAM enzyme-specific profiles | 2.7.1.192 |
KEGG Ligand Database for Enzyme Nomenclature | 2.7.1.192 |
IUBMB Enzyme Nomenclature | 2.7.1.192 |
IntEnz | 2.7.1.192 |
MEDLINE | Find literature relating to 2.7.1.192 |
MetaCyc | 2.7.1.192 |
Rhea expert-curated reactions | 2.7.1.192 |
UniProtKB/Swiss-Prot |
Q5E5T6, PTYBC_ALIF1; | Q8XBJ1, PTYBC_ECO57; | Q8FFA9, PTYBC_ECOL6; |
P77272, PTYBC_ECOLI; | Q1R8U3, PTYBC_ECOUT; | Q9CKN5, PTYBC_PASMU; |
Q7N9D9, PTYBC_PHOLL; | Q31Y50, PTYBC_SHIBS; | Q32DC5, PTYBC_SHIDS; |
Q83QN3, PTYBC_SHIFL; | Q9KVD9, PTYBC_VIBCH; | Q87FD5, PTYBC_VIBPA; |
Q8D4Z3, PTYBC_VIBVU; | Q7MBS2, PTYBC_VIBVY; |
|
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UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
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