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ENZYME

ENZYME entry: EC 2.7.1.193

Accepted Name
protein-N(pi)-phosphohistidine--N-acetyl-D-glucosamine phosphotransferase
Alternative Name(s)
N-acetyl-D-glucosamine PTS permease
Reaction catalysed
N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) = L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)
Comment(s)
  • This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS).
  • The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it.
  • The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9.
  • Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency.
  • The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
  • Formerly EC 2.7.1.69.
Cross-references
BRENDA2.7.1.193
EC2PDB2.7.1.193
ExplorEnz2.7.1.193
PRIAM enzyme-specific profiles2.7.1.193
KEGG Ligand Database for Enzyme Nomenclature2.7.1.193
IUBMB Enzyme Nomenclature2.7.1.193
IntEnz2.7.1.193
MEDLINEFind literature relating to 2.7.1.193
MetaCyc2.7.1.193
Rhea expert-curated reactions2.7.1.193
UniProtKB/Swiss-Prot
P09323, PTW3C_ECOLIP45604, PTW3C_KLEPNQ9S2H6, PTWB_STRCO
O34521, PTWCB_BACSU

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