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ENZYME

ENZYME entry: EC 2.7.1.194

Accepted Name
protein-N(pi)-phosphohistidine--L-ascorbate phosphotransferase
Alternative Name(s)
L-ascorbate PTS permease
Reaction catalysed
L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-ascorbate 6-phosphate(in) + L-histidyl-[protein]
Comment(s)
  • This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS).
  • The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it.
  • The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9.
  • Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency.
  • The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
  • Formerly EC 2.7.1.69.
Cross-references
BRENDA2.7.1.194
EC2PDB2.7.1.194
ExplorEnz2.7.1.194
PRIAM enzyme-specific profiles2.7.1.194
KEGG Ligand Database for Enzyme Nomenclature2.7.1.194
IUBMB Enzyme Nomenclature2.7.1.194
IntEnz2.7.1.194
MEDLINEFind literature relating to 2.7.1.194
MetaCyc2.7.1.194
Rhea expert-curated reactions2.7.1.194
UniProtKB/Swiss-Prot
P69823, ULAB_ECO57Q8FAJ1, ULAB_ECOL6P69822, ULAB_ECOLI
Q9EXD8, ULAB_MYCPNQ57GJ8, ULAB_SALCHQ5PJ47, ULAB_SALPA
Q8Z171, ULAB_SALTIQ8ZK89, ULAB_SALTYQ31TC5, ULAB_SHIBS
Q328K3, ULAB_SHIDSQ83P29, ULAB_SHIFLQ3YUF4, ULAB_SHISS

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