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ENZYME entry: EC 2.7.1.197
Accepted Name |
protein-N(pi)-phosphohistidine--D-mannitol phosphotransferase.
|
Alternative Name(s) |
D-mannitol PTS permease. |
Reaction catalysed |
D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-mannitol 1-phosphate(in) + L-histidyl-[protein] |
Comment(s) |
- This enzyme is a component (known as enzyme II) of a
phosphoenolpyruvate (PEP)-dependent, sugar transporting
phosphotransferase system (PTS).
- The system, which is found only in prokaryotes, simultaneously
transports its substrate from the periplasm or extracellular space
into the cytoplasm and phosphorylates it.
- The phosphate donor, which is shared among the different systems,
is a phospho-carrier protein of low molecular mass that has been
phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate--protein
phosphotransferase).
- Enzyme II, on the other hand, is specific for a particular substrate,
although in some cases alternative substrates can be transported with
lower efficiency.
- The reaction involves a successive transfer of the phosphate group to
several amino acids within the enzyme before the final transfer to
the substrate.
- Formerly EC 2.7.1.69.
|
Cross-references |
BRENDA | 2.7.1.197 |
EC2PDB | 2.7.1.197 |
ExplorEnz | 2.7.1.197 |
PRIAM enzyme-specific profiles | 2.7.1.197 |
KEGG Ligand Database for Enzyme Nomenclature | 2.7.1.197 |
IUBMB Enzyme Nomenclature | 2.7.1.197 |
IntEnz | 2.7.1.197 |
MEDLINE | Find literature relating to 2.7.1.197 |
MetaCyc | 2.7.1.197 |
Rhea expert-curated reactions | 2.7.1.197 |
UniProtKB/Swiss-Prot |
P96574, MTLR_BACSU; | P57635, PTM3C_BUCAI; | Q8K911, PTM3C_BUCAP; |
Q89A36, PTM3C_BUCBP; | P00550, PTM3C_ECOLI; | Q9XBM7, PTM3C_KLEPN; |
Q9CLY8, PTM3C_PASMU; | Q9KKQ7, PTM3C_VIBCH; | Q9K678, PTMCB_ALKHC; |
P42956, PTMCB_BACSU; | O65989, PTMCB_CLOAB; | P69827, PTMCB_ECO57; |
P69826, PTMCB_ECOLI; | P50852, PTMCB_GEOSE; | P75146, PTMCB_MYCPN; |
Q5HE48, PTMCB_STAAC; | Q99SA3, PTMCB_STAAM; | Q7A4B3, PTMCB_STAAN; |
Q6GES1, PTMCB_STAAR; | Q6G7F6, PTMCB_STAAS; | Q7A0A4, PTMCB_STAAW; |
P28008, PTMCB_STACA; | Q4L9Y1, PTMCB_STAHJ; | Q49ZA3, PTMCB_STAS1; |
Q9KJ75, PTMCB_STRMU; | Q97SH4, PTMCB_STRPN; | Q8DR34, PTMCB_STRR6; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
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