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ENZYME entry: EC 2.7.1.197

Accepted Name
Protein-N(pi)-phosphohistidine--D-mannitol phosphotransferase.
Alternative Name(s)
D-mannitol PTS permease.
Reaction catalysed
[Protein]-N(pi)-phospho-L-histidine + D-mannitol(Side 1) <=> [protein]-L-histidine + D-mannitol 1-phosphate(Side 2)
Comment(s)
  • This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS).
  • The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it.
  • The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate--protein phosphotransferase).
  • Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency.
  • The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
  • Formerly EC 2.7.1.69.
Cross-references
PROSITEPDOC00795
BRENDA2.7.1.197
EC2PDB2.7.1.197
ExplorEnz2.7.1.197
PRIAM enzyme-specific profiles2.7.1.197
KEGG Ligand Database for Enzyme Nomenclature2.7.1.197
IUBMB Enzyme Nomenclature2.7.1.197
IntEnz2.7.1.197
MEDLINEFind literature relating to 2.7.1.197
MetaCyc2.7.1.197
UniProtKB/Swiss-Prot
P96574, MTLR_BACSU;  P57635, PTM3C_BUCAI;  Q8K911, PTM3C_BUCAP;  
Q89A36, PTM3C_BUCBP;  P00550, PTM3C_ECOLI;  Q9XBM7, PTM3C_KLEPN;  
Q9CLY8, PTM3C_PASMU;  Q9KKQ7, PTM3C_VIBCH;  Q9K678, PTMCB_BACHD;  
P42956, PTMCB_BACSU;  O65989, PTMCB_CLOAB;  P69827, PTMCB_ECO57;  
P69826, PTMCB_ECOLI;  P50852, PTMCB_GEOSE;  P75146, PTMCB_MYCPN;  
Q5HE48, PTMCB_STAAC;  Q99SA3, PTMCB_STAAM;  Q7A4B3, PTMCB_STAAN;  
Q6GES1, PTMCB_STAAR;  Q6G7F6, PTMCB_STAAS;  Q7A0A4, PTMCB_STAAW;  
P28008, PTMCB_STACA;  Q4L9Y1, PTMCB_STAHJ;  Q49ZA3, PTMCB_STAS1;  
Q9KJ75, PTMCB_STRMU;  Q97SH4, PTMCB_STRPN;  Q8DR34, PTMCB_STRR6;  

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