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ENZYME

ENZYME entry: EC 2.7.1.197

Accepted Name
protein-N(pi)-phosphohistidine--D-mannitol phosphotransferase
Alternative Name(s)
D-mannitol PTS permease
Reaction catalysed
D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannitol 1-phosphate(in) + L-histidyl-[protein]
Comment(s)
  • This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS).
  • The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it.
  • The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate--protein phosphotransferase).
  • Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency.
  • The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
  • Formerly EC 2.7.1.69.
Cross-references
BRENDA2.7.1.197
EC2PDB2.7.1.197
ExplorEnz2.7.1.197
PRIAM enzyme-specific profiles2.7.1.197
KEGG Ligand Database for Enzyme Nomenclature2.7.1.197
IUBMB Enzyme Nomenclature2.7.1.197
IntEnz2.7.1.197
MEDLINEFind literature relating to 2.7.1.197
MetaCyc2.7.1.197
Rhea expert-curated reactions2.7.1.197
UniProtKB/Swiss-Prot
P96574, MTLR_BACSUP57635, PTM3C_BUCAIQ8K911, PTM3C_BUCAP
Q89A36, PTM3C_BUCBPP00550, PTM3C_ECOLIQ9XBM7, PTM3C_KLEPN
Q9CLY8, PTM3C_PASMUQ9KKQ7, PTM3C_VIBCHP42956, PTMCB_BACSU
O65989, PTMCB_CLOABP69827, PTMCB_ECO57P69826, PTMCB_ECOLI
P50852, PTMCB_GEOSEQ9K678, PTMCB_HALH5P75146, PTMCB_MYCPN
Q5HE48, PTMCB_STAACQ99SA3, PTMCB_STAAMQ7A4B3, PTMCB_STAAN
Q6GES1, PTMCB_STAARQ6G7F6, PTMCB_STAASQ7A0A4, PTMCB_STAAW
P28008, PTMCB_STACAQ4L9Y1, PTMCB_STAHJQ49ZA3, PTMCB_STAS1
Q9KJ75, PTMCB_STRMUQ97SH4, PTMCB_STRPNQ8DR34, PTMCB_STRR6

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
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