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ENZYME entry: EC

Accepted Name
protein-N(pi)-phosphohistidine--D-sorbitol phosphotransferase
Alternative Name(s)
D-sorbitol PTS permease
glucitol PTS permease
sorbitol PTS permease
Reaction catalysed
D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-sorbitol 6-phosphate(in) + L-histidyl-[protein]
  • This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS).
  • The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it.
  • The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC
  • Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency.
  • The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
  • Formerly EC
PRIAM enzyme-specific profiles2.7.1.198
KEGG Ligand Database for Enzyme Nomenclature2.7.1.198
IUBMB Enzyme Nomenclature2.7.1.198
MEDLINEFind literature relating to
Rhea expert-curated reactions2.7.1.198

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