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ENZYME

ENZYME entry: EC 2.7.1.199

PURL: https://purl.expasy.org/enzyme/EC/2.7.1.199
Accepted Name
protein-N(pi)-phosphohistidine--D-glucose phosphotransferase
Alternative Name(s)
D-glucose PTS permease
Reaction catalysed
N(pros)-phospho-L-histidyl-[protein] + D-glucose(out) = D-glucose 6-phosphate(in) + L-histidyl-[protein]
Comment(s)
  • This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS).
  • The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it.
  • The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9.
  • Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency.
  • The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
  • Formerly EC 2.7.1.69.
Cross-references
BRENDA2.7.1.199
EC2PDB2.7.1.199
ExplorEnz2.7.1.199
KEGG Ligand Database for Enzyme Nomenclature2.7.1.199
IUBMB Enzyme Nomenclature2.7.1.199
MEDLINEFind literature relating to 2.7.1.199
MetaCyc2.7.1.199
Rhea expert-curated reactions2.7.1.199
UniProtKB/Swiss-Prot
Q45298, PTG3B_CORGTP20166, PTG3C_BACSUP42015, PTG3C_GEOSE
P47315, PTG3C_MYCGEP75569, PTG3C_MYCPNA7WXI2, PTG3C_STAA1
A6TXX3, PTG3C_STAA2Q2FK73, PTG3C_STAA3Q2G1G8, PTG3C_STAA8
A5IP58, PTG3C_STAA9Q2YUZ1, PTG3C_STAABQ5HJI3, PTG3C_STAAC
A6QDH3, PTG3C_STAAEQ99X32, PTG3C_STAAMQ7A807, PTG3C_STAAN
Q6GKB7, PTG3C_STAARQ6GCT7, PTG3C_STAASA8Z0F5, PTG3C_STAAT
Q8NYM1, PTG3C_STAAWQ57071, PTG3C_STACTQ8VRH0, PTG3C_STAEP
Q5HL73, PTG3C_STAEQQ7CCJ4, PTG3C_STAESQ4L945, PTG3C_STAHJ
Q4A0C4, PTG3C_STAS1P35595, PTG3C_STRPNP57437, PTGCB_BUCAI
Q8K9J0, PTGCB_BUCAPQ89AG6, PTGCB_BUCBPP69788, PTGCB_ECO57
P69787, PTGCB_ECOL6P69786, PTGCB_ECOLIP37439, PTGCB_SALTY

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-