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ENZYME entry: EC 2.7.1.199

Accepted Name
Protein-N(pi)-phosphohistidine--D-glucose phosphotransferase.
Alternative Name(s)
D-glucose PTS permease.
Reaction catalysed
[Protein]-N(pi)-phospho-L-histidine + D-glucose(Side 1) <=> [protein]-L-histidine + D-glucose 6-phosphate(Side 2)
Comment(s)
  • This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS).
  • The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it.
  • The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9.
  • Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency.
  • The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
  • Formerly EC 2.7.1.69.
Cross-references
PROSITEPDOC00795
BRENDA2.7.1.199
EC2PDB2.7.1.199
ExplorEnz2.7.1.199
PRIAM enzyme-specific profiles2.7.1.199
KEGG Ligand Database for Enzyme Nomenclature2.7.1.199
IUBMB Enzyme Nomenclature2.7.1.199
IntEnz2.7.1.199
MEDLINEFind literature relating to 2.7.1.199
MetaCyc2.7.1.199
UniProtKB/Swiss-Prot
Q45298, PTG3B_CORGT;  P20166, PTG3C_BACSU;  P42015, PTG3C_GEOSE;  
P47315, PTG3C_MYCGE;  P75569, PTG3C_MYCPN;  A7WXI2, PTG3C_STAA1;  
A6TXX3, PTG3C_STAA2;  Q2FK73, PTG3C_STAA3;  Q2G1G8, PTG3C_STAA8;  
A5IP58, PTG3C_STAA9;  Q2YUZ1, PTG3C_STAAB;  Q5HJI3, PTG3C_STAAC;  
A6QDH3, PTG3C_STAAE;  Q99X32, PTG3C_STAAM;  Q7A807, PTG3C_STAAN;  
Q6GKB7, PTG3C_STAAR;  Q6GCT7, PTG3C_STAAS;  A8Z0F5, PTG3C_STAAT;  
Q8NYM1, PTG3C_STAAW;  Q57071, PTG3C_STACT;  Q8VRH0, PTG3C_STAEP;  
Q5HL73, PTG3C_STAEQ;  Q7CCJ4, PTG3C_STAES;  Q4L945, PTG3C_STAHJ;  
Q4A0C4, PTG3C_STAS1;  P35595, PTG3C_STRPN;  P57437, PTGCB_BUCAI;  
Q8K9J0, PTGCB_BUCAP;  Q89AG6, PTGCB_BUCBP;  P69788, PTGCB_ECO57;  
P69787, PTGCB_ECOL6;  P69786, PTGCB_ECOLI;  P37439, PTGCB_SALTY;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
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