| Accepted Name |
|---|
| Protein-N(pi)-phosphohistidine--D-glucose phosphotransferase.
|
| Alternative Name(s) |
|---|
| D-glucose PTS permease. |
| Reaction catalysed |
|---|
| [Protein]-N(pi)-phospho-L-histidine + D-glucose(Side 1) <=> [protein]-L-histidine + D-glucose 6-phosphate(Side 2) |
| Comment(s) |
|---|
- This enzyme is a component (known as enzyme II) of a
phosphoenolpyruvate (PEP)-dependent, sugar transporting
phosphotransferase system (PTS).
- The system, which is found only in prokaryotes, simultaneously
transports its substrate from the periplasm or extracellular space
into the cytoplasm and phosphorylates it.
- The phosphate donor, which is shared among the different systems,
is a phospho-carrier protein of low molecular mass that has been
phosphorylated by EC 2.7.3.9.
- Enzyme II, on the other hand, is specific for a particular substrate,
although in some cases alternative substrates can be transported with
lower efficiency.
- The reaction involves a successive transfer of the phosphate group to
several amino acids within the enzyme before the final transfer to
the substrate.
- Formerly EC 2.7.1.69.
|
| Cross-references |
|---|
| PROSITE | PDOC00795 |
| BRENDA | 2.7.1.199 |
| EC2PDB | 2.7.1.199 |
| ExplorEnz | 2.7.1.199 |
| PRIAM enzyme-specific profiles | 2.7.1.199 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.7.1.199 |
| IUBMB Enzyme Nomenclature | 2.7.1.199 |
| IntEnz | 2.7.1.199 |
| MEDLINE | Find literature relating to 2.7.1.199 |
| MetaCyc | 2.7.1.199 |
| UniProtKB/Swiss-Prot |
| Q45298, PTG3B_CORGT; | P20166, PTG3C_BACSU; | P42015, PTG3C_GEOSE; |
| P47315, PTG3C_MYCGE; | P75569, PTG3C_MYCPN; | A7WXI2, PTG3C_STAA1; |
| A6TXX3, PTG3C_STAA2; | Q2FK73, PTG3C_STAA3; | Q2G1G8, PTG3C_STAA8; |
| A5IP58, PTG3C_STAA9; | Q2YUZ1, PTG3C_STAAB; | Q5HJI3, PTG3C_STAAC; |
| A6QDH3, PTG3C_STAAE; | Q99X32, PTG3C_STAAM; | Q7A807, PTG3C_STAAN; |
| Q6GKB7, PTG3C_STAAR; | Q6GCT7, PTG3C_STAAS; | A8Z0F5, PTG3C_STAAT; |
| Q8NYM1, PTG3C_STAAW; | Q57071, PTG3C_STACT; | Q8VRH0, PTG3C_STAEP; |
| Q5HL73, PTG3C_STAEQ; | Q7CCJ4, PTG3C_STAES; | Q4L945, PTG3C_STAHJ; |
| Q4A0C4, PTG3C_STAS1; | P35595, PTG3C_STRPN; | P57437, PTGCB_BUCAI; |
| Q8K9J0, PTGCB_BUCAP; | Q89AG6, PTGCB_BUCBP; | P69788, PTGCB_ECO57; |
| P69787, PTGCB_ECOL6; | P69786, PTGCB_ECOLI; | P37439, PTGCB_SALTY; |
|