A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_09. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Protein-N(pi)-phosphohistidine--D-fructose phosphotransferase.
Alternative Name(s)
Fructose PTS permease.
Reaction catalysed
[Protein]-N(pi)-phospho-L-histidine + D-fructose(Side 1) <=> [protein]-L-histidine + D-fructose 1-phosphate(Side 2)
  • This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS).
  • The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it.
  • The phosphate donor, which is shared among the different systems, is usually a phospho-carrier protein of low molecular mass that has been phosphorylated by EC
  • The enzyme from the bacterium Escherichia coli is an exception, since it is phosphorylated directly by EC
  • The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
  • Formerly EC
PRIAM enzyme-specific profiles2.7.1.202
KEGG Ligand Database for Enzyme Nomenclature2.7.1.202
IUBMB Enzyme Nomenclature2.7.1.202
MEDLINEFind literature relating to
P71012, PTF3A_BACSU;  P47308, PTF3A_MYCGE;  P75039, PTF3A_MYCPN;  
P69810, PTFB1_ECO57;  P69809, PTFB1_ECOL6;  P69808, PTFB1_ECOLI;  
Q821A9, PTFB1_SHIFL;  P69818, PTFB2_ECO57;  P69817, PTFB2_ECOL6;  
P69816, PTFB2_ECOLI;  P69819, PTFB2_SHIFL;  P32676, PTFB3_ECOLI;  
P20966, PTFBC_ECOLI;  P44714, PTFBC_HAEIN;  P23387, PTFBC_RHOCA;  
P32154, PTFLB_ECOLI;  P77439, PTFX1_ECOLI;  P32670, PTFX2_ECOLI;  

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