ENZYME entry: EC 2.7.1.227
Accepted Name |
Inositol phosphorylceramide synthase.
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Reaction catalysed |
1-phosphatidyl-1D-myo-inositol + a very-long-chain (2'R)-2'-hydroxy-phytoceramide <=> 1,2-diacyl-sn-glycerol + a (4R)-4-hydroxy-N-((2R)-2-hydroxy-very-long-chain-acyl)-1-O-((1D-myo-inositol-1-O-yl)hydroxyphosphoryl)sphinganine |
Comment(s) |
The enzyme, characterized from yeast, attaches a phosphoinositol
headgroup to alpha-hydroxyphytoceramides, generating a very-long-
chain inositol phospho-alpha hydroxyphytoceramide (IPC), the simplest
of the three complex sphingolipids produced by yeast.
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Cross-references |
BRENDA | 2.7.1.227 |
EC2PDB | 2.7.1.227 |
ExplorEnz | 2.7.1.227 |
PRIAM enzyme-specific profiles | 2.7.1.227 |
KEGG Ligand Database for Enzyme Nomenclature | 2.7.1.227 |
IUBMB Enzyme Nomenclature | 2.7.1.227 |
IntEnz | 2.7.1.227 |
MEDLINE | Find literature relating to 2.7.1.227 |
MetaCyc | 2.7.1.227 |
Rhea expert-curated reactions | 2.7.1.227 |
UniProtKB/Swiss-Prot |
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