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ENZYME entry: EC 2.7.1.227

Accepted Name
Inositol phosphorylceramide synthase.
Reaction catalysed
1-phosphatidyl-1D-myo-inositol + a very-long-chain (2'R)-2'-hydroxy-phytoceramide <=> 1,2-diacyl-sn-glycerol + a (4R)-4-hydroxy-N-((2R)-2-hydroxy-very-long-chain-acyl)-1-O-((1D-myo-inositol-1-O-yl)hydroxyphosphoryl)sphinganine
Comment(s)
The enzyme, characterized from yeast, attaches a phosphoinositol headgroup to alpha-hydroxyphytoceramides, generating a very-long- chain inositol phospho-alpha hydroxyphytoceramide (IPC), the simplest of the three complex sphingolipids produced by yeast.
Cross-references
BRENDA2.7.1.227
EC2PDB2.7.1.227
ExplorEnz2.7.1.227
PRIAM enzyme-specific profiles2.7.1.227
KEGG Ligand Database for Enzyme Nomenclature2.7.1.227
IUBMB Enzyme Nomenclature2.7.1.227
IntEnz2.7.1.227
MEDLINEFind literature relating to 2.7.1.227
MetaCyc2.7.1.227
Rhea expert-curated reactions2.7.1.227
UniProtKB/Swiss-Prot
P36107, AUR1_YEAST;  Q84WB7, GINT1_ARATH;  Q9SH93, IPCS2_ARATH;  

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