ENZYME entry: EC 2.7.1.227
| Accepted Name |
|---|
| inositol phosphorylceramide synthase.
|
| Reaction catalysed |
|---|
| a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base |
| Comment(s) |
|---|
| The enzyme, characterized from yeast, attaches a phosphoinositol
headgroup to alpha-hydroxyphytoceramides, generating a very-long-
chain inositol phospho-alpha hydroxyphytoceramide (IPC), the simplest
of the three complex sphingolipids produced by yeast.
|
| Cross-references |
|---|
| BRENDA | 2.7.1.227 |
| EC2PDB | 2.7.1.227 |
| ExplorEnz | 2.7.1.227 |
| PRIAM enzyme-specific profiles | 2.7.1.227 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.7.1.227 |
| IUBMB Enzyme Nomenclature | 2.7.1.227 |
| IntEnz | 2.7.1.227 |
| MEDLINE | Find literature relating to 2.7.1.227 |
| MetaCyc | 2.7.1.227 |
| Rhea expert-curated reactions | 2.7.1.227 |
| UniProtKB/Swiss-Prot |
|
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