ENZYME entry: EC 2.7.1.227
| Accepted Name | ||||
|---|---|---|---|---|
| inositol phosphorylceramide synthase | ||||
| Reaction catalysed | ||||
| an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + a 1,2-diacyl-sn-glycerol | ||||
| Comment(s) | ||||
| The enzyme, characterized from yeast, attaches a phosphoinositol headgroup to alpha-hydroxyphytoceramides, generating a very-long- chain inositol phospho-alpha hydroxyphytoceramide (IPC), the simplest of the three complex sphingolipids produced by yeast. | ||||
| Cross-references | ||||
| BRENDA | 2.7.1.227 | |||
| EC2PDB | 2.7.1.227 | |||
| ExplorEnz | 2.7.1.227 | |||
| KEGG Ligand Database for Enzyme Nomenclature | 2.7.1.227 | |||
| IUBMB Enzyme Nomenclature | 2.7.1.227 | |||
| MEDLINE | Find literature relating to 2.7.1.227 | |||
| MetaCyc | 2.7.1.227 | |||
| Rhea expert-curated reactions | 2.7.1.227 | |||
| UniProtKB/Swiss-Prot |
| |||
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