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ENZYME

ENZYME entry: EC 2.7.11.2

PURL: https://purl.expasy.org/enzyme/EC/2.7.11.2
Accepted Name
[pyruvate dehydrogenase (acetyl-transferring)] kinase
Alternative Name(s)
PDHK
PDH kinase
PDK
pyruvate dehydrogenase kinase
pyruvate dehydrogenase kinase (phosphorylating)
Reaction catalysed
L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)
Comment(s)
  • Has no activating compound but is specific for its substrate.
  • A mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals.
  • Phosphorylation inactivates EC 1.2.4.1.
  • Formerly EC 2.7.1.99.
Cross-references
BRENDA2.7.11.2
EC2PDB2.7.11.2
ExplorEnz2.7.11.2
KEGG Ligand Database for Enzyme Nomenclature2.7.11.2
IUBMB Enzyme Nomenclature2.7.11.2
MEDLINEFind literature relating to 2.7.11.2
MetaCyc2.7.11.2
Rhea expert-curated reactions2.7.11.2
UniProtKB/Swiss-Prot
Q02332, PDHK2_CAEELQ15118, PDK1_HUMANQ8BFP9, PDK1_MOUSE
Q63065, PDK1_RATP40530, PDK1_YEASTQ15119, PDK2_HUMAN
Q9JK42, PDK2_MOUSEQ64536, PDK2_RATP53170, PDK2_YEAST
Q15120, PDK3_HUMANQ922H2, PDK3_MOUSEQ16654, PDK4_HUMAN
O88345, PDK4_ICTTRO70571, PDK4_MOUSEO54937, PDK4_RAT
Q1KMR4, PDK4_RHIFEQ9SBJ1, PDK_ARATHO02623, PDK_ASCSU
P91622, PDK_DROMEQ9P6P9, PDK_SCHPO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
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