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ENZYME entry: EC 1.2.4.1

Accepted Name
Pyruvate dehydrogenase (acetyl-transferring).
Alternative Name(s)
Pyruvate decarboxylase.
Pyruvate dehydrogenase.
Pyruvate dehydrogenase (lipoamide).
Pyruvate dehydrogenase complex.
Pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor- acetylating).
Pyruvic acid dehydrogenase.
Pyruvic dehydrogenase.
Reaction catalysed
Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine <=> [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2)
Cofactor(s)
Thiamine diphosphate.
Comment(s)
  • It is a component (in multiple copies) of the multienzyme pyruvate dehydrogenase complex in which it is bound to a core of molecules of EC 2.3.1.12, which also binds multiple copies of EC 1.8.1.4.
  • It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.12.
Cross-references
BRENDA1.2.4.1
EC2PDB1.2.4.1
ExplorEnz1.2.4.1
PRIAM enzyme-specific profiles1.2.4.1
KEGG Ligand Database for Enzyme Nomenclature1.2.4.1
IUBMB Enzyme Nomenclature1.2.4.1
IntEnz1.2.4.1
MEDLINEFind literature relating to 1.2.4.1
MetaCyc1.2.4.1
UniProtKB/Swiss-Prot
P10801, ODP1_AZOVI;  P57301, ODP1_BUCAI;  Q8K9T9, ODP1_BUCAP;  
Q89AR0, ODP1_BUCBP;  Q8NNF6, ODP1_CORGL;  Q59097, ODP1_CUPNH;  
P0AFG9, ODP1_ECO57;  P0AFG8, ODP1_ECOLI;  P45119, ODP1_HAEIN;  
A0R0B0, ODP1_MYCS2;  P9WIS8, ODP1_MYCTO;  P9WIS9, ODP1_MYCTU;  
Q59637, ODP1_PSEAE;  P52901, ODPA1_ARATH;  Q6Z5N4, ODPA1_ORYSJ;  
Q8H1Y0, ODPA2_ARATH;  Q654V6, ODPA2_ORYSJ;  O24457, ODPA3_ARATH;  
Q7XTJ3, ODPA3_ORYSJ;  P29803, ODPAT_HUMAN;  P35487, ODPAT_MOUSE;  
Q06437, ODPAT_RAT;  P35485, ODPA_ACHLA;  P26267, ODPA_ASCSU;  
Q4MTG0, ODPA_BACCE;  P21881, ODPA_BACSU;  A7MB35, ODPA_BOVIN;  
P52899, ODPA_CAEEL;  P49823, ODPA_CANLF;  Q54C70, ODPA_DICDI;  
P21873, ODPA_GEOSE;  P08559, ODPA_HUMAN;  O13366, ODPA_KLULA;  
Q8HXW9, ODPA_MACFA;  P35486, ODPA_MOUSE;  P47516, ODPA_MYCGE;  
P75390, ODPA_MYCPN;  A5A6L0, ODPA_PANTR;  P52902, ODPA_PEA;  
P29804, ODPA_PIG;  Q5R490, ODPA_PONAB;  P51267, ODPA_PORPU;  
Q1XDM0, ODPA_PYRYE;  P26284, ODPA_RAT;  Q9R9N5, ODPA_RHIME;  
Q1RJX4, ODPA_RICBR;  Q92IS3, ODPA_RICCN;  Q4UKQ6, ODPA_RICFE;  
Q9ZDR4, ODPA_RICPR;  Q68XA9, ODPA_RICTY;  Q10489, ODPA_SCHPO;  
P52900, ODPA_SMIMA;  P52903, ODPA_SOLTU;  Q5HGZ1, ODPA_STAAC;  
P60089, ODPA_STAAM;  Q820A6, ODPA_STAAN;  Q6GHZ2, ODPA_STAAR;  
Q6GAC1, ODPA_STAAS;  P60090, ODPA_STAAW;  Q5HQ76, ODPA_STAEQ;  
Q8CPN3, ODPA_STAES;  P16387, ODPA_YEAST;  O66112, ODPA_ZYMMO;  
Q38799, ODPB1_ARATH;  Q6Z1G7, ODPB1_ORYSJ;  Q9C6Z3, ODPB2_ARATH;  
Q0J0H4, ODPB2_ORYSJ;  O64688, ODPB3_ARATH;  Q2QM55, ODPB3_ORYSJ;  
Q10G39, ODPB4_ORYSJ;  P35488, ODPB_ACHLA;  P26269, ODPB_ASCSU;  
P21882, ODPB_BACSU;  P11966, ODPB_BOVIN;  O44451, ODPB_CAEEL;  
Q8MA03, ODPB_CHAGL;  Q1ACL0, ODPB_CHAVU;  A2CI50, ODPB_CHLAT;  
Q9TLS3, ODPB_CYACA;  Q85FX1, ODPB_CYAM1;  Q86HX0, ODPB_DICDI;  
P21874, ODPB_GEOSE;  Q6B8T1, ODPB_GRATL;  P11177, ODPB_HUMAN;  
Q6ABX8, ODPB_LEIXX;  P86222, ODPB_MESAU;  Q9MUR4, ODPB_MESVI;  
Q9D051, ODPB_MOUSE;  P47515, ODPB_MYCGE;  P75391, ODPB_MYCPN;  
P52904, ODPB_PEA;  Q5RE79, ODPB_PONAB;  P51266, ODPB_PORPU;  
Q1XDM1, ODPB_PYRYE;  P49432, ODPB_RAT;  Q9R9N4, ODPB_RHIME;  
Q1RJX3, ODPB_RICBR;  Q92IS2, ODPB_RICCN;  Q4UKQ7, ODPB_RICFE;  
Q9ZDR3, ODPB_RICPR;  Q68XA8, ODPB_RICTY;  Q09171, ODPB_SCHPO;  
P81419, ODPB_SOLTU;  Q5HGZ0, ODPB_STAAC;  P0A0A1, ODPB_STAAM;  
P99063, ODPB_STAAN;  Q6GHZ1, ODPB_STAAR;  Q6GAC0, ODPB_STAAS;  
P0A0A3, ODPB_STAAU;  P0A0A2, ODPB_STAAW;  Q5HQ75, ODPB_STAEQ;  
Q8CPN2, ODPB_STAES;  Q32RS0, ODPB_STAPU;  P32473, ODPB_YEAST;  
Q32RM2, ODPB_ZYGCR;  O66113, ODPB_ZYMMO;  P26268, ODPT_ASCSU;  

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