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ENZYME

ENZYME entry: EC 1.2.4.1

PURL: https://purl.expasy.org/enzyme/EC/1.2.4.1
Accepted Name
pyruvate dehydrogenase (acetyl-transferring)
Alternative Name(s)
pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor- acetylating)
pyruvate decarboxylase
pyruvate dehydrogenase
pyruvate dehydrogenase (lipoamide)
pyruvate dehydrogenase complex
pyruvic acid dehydrogenase
pyruvic dehydrogenase
Reaction catalysed
N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2
Comment(s)
  • It is a component (in multiple copies) of EC 1.2.1.104 in which it is bound to a core of molecules of EC 2.3.1.12, which also binds multiple copies of EC 1.8.1.4.
  • It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.12.
Cross-references
Rhea expert-curated reactions1.2.4.1
ExplorEnz1.2.4.1
IUBMB Enzyme Nomenclature1.2.4.1
UniProtKB/Swiss-Prot
P10801, ODP1_AZOVIP57301, ODP1_BUCAIQ8K9T9, ODP1_BUCAP
Q89AR0, ODP1_BUCBPQ8NNF6, ODP1_CORGLQ59097, ODP1_CUPNH
P0AFG9, ODP1_ECO57P0AFG8, ODP1_ECOLIP45119, ODP1_HAEIN
A0R0B0, ODP1_MYCS2P9WIS8, ODP1_MYCTOP9WIS9, ODP1_MYCTU
Q59637, ODP1_PSEAEP52901, ODPA1_ARATHQ6Z5N4, ODPA1_ORYSJ
Q8H1Y0, ODPA2_ARATHQ654V6, ODPA2_ORYSJO24457, ODPA3_ARATH
Q7XTJ3, ODPA3_ORYSJP29803, ODPAT_HUMANP35487, ODPAT_MOUSE
Q06437, ODPAT_RATP35485, ODPA_ACHLAP26267, ODPA_ASCSU
Q4MTG0, ODPA_BACCEP21881, ODPA_BACSUA7MB35, ODPA_BOVIN
P52899, ODPA_CAEELP49823, ODPA_CANLFQ54C70, ODPA_DICDI
P21873, ODPA_GEOSEP08559, ODPA_HUMANO13366, ODPA_KLULA
Q8HXW9, ODPA_MACFAP35486, ODPA_MOUSEP47516, ODPA_MYCGE
P75390, ODPA_MYCPNA5A6L0, ODPA_PANTRP52902, ODPA_PEA
P29804, ODPA_PIGQ5R490, ODPA_PONABP51267, ODPA_PORPU
Q1XDM0, ODPA_PYRYEP26284, ODPA_RATQ9R9N5, ODPA_RHIME
Q1RJX4, ODPA_RICBRQ92IS3, ODPA_RICCNQ4UKQ6, ODPA_RICFE
Q9ZDR4, ODPA_RICPRQ68XA9, ODPA_RICTYQ10489, ODPA_SCHPO
P52900, ODPA_SMIMAP52903, ODPA_SOLTUQ5HGZ1, ODPA_STAAC
P60089, ODPA_STAAMQ820A6, ODPA_STAANQ6GHZ2, ODPA_STAAR
Q6GAC1, ODPA_STAASP60090, ODPA_STAAWQ5HQ76, ODPA_STAEQ
Q8CPN3, ODPA_STAESG0SHF3, ODPA_THET3P16387, ODPA_YEAST
O66112, ODPA_ZYMMOQ38799, ODPB1_ARATHQ6Z1G7, ODPB1_ORYSJ
Q9C6Z3, ODPB2_ARATHQ0J0H4, ODPB2_ORYSJO64688, ODPB3_ARATH
Q2QM55, ODPB3_ORYSJQ10G39, ODPB4_ORYSJP35488, ODPB_ACHLA
P26269, ODPB_ASCSUP21882, ODPB_BACSUP11966, ODPB_BOVIN
O44451, ODPB_CAEELQ8MA03, ODPB_CHAGLQ1ACL0, ODPB_CHAVU
A2CI50, ODPB_CHLATQ9TLS3, ODPB_CYACAQ85FX1, ODPB_CYAM1
Q86HX0, ODPB_DICDIQ7K5K3, ODPB_DROMEP21874, ODPB_GEOSE
Q6B8T1, ODPB_GRATLP11177, ODPB_HUMANQ6ABX8, ODPB_LEIXX
P86222, ODPB_MESAUQ9MUR4, ODPB_MESVIQ9D051, ODPB_MOUSE
P47515, ODPB_MYCGEP75391, ODPB_MYCPNP52904, ODPB_PEA
Q5RE79, ODPB_PONABP51266, ODPB_PORPUQ1XDM1, ODPB_PYRYE
P49432, ODPB_RATQ9R9N4, ODPB_RHIMEQ1RJX3, ODPB_RICBR
Q92IS2, ODPB_RICCNQ4UKQ7, ODPB_RICFEQ9ZDR3, ODPB_RICPR
Q68XA8, ODPB_RICTYQ09171, ODPB_SCHPOP81419, ODPB_SOLTU
Q5HGZ0, ODPB_STAACP0A0A1, ODPB_STAAMP99063, ODPB_STAAN
Q6GHZ1, ODPB_STAARQ6GAC0, ODPB_STAASP0A0A3, ODPB_STAAU
P0A0A2, ODPB_STAAWQ5HQ75, ODPB_STAEQQ8CPN2, ODPB_STAES
Q32RS0, ODPB_STAPUG0RYE0, ODPB_THET3P32473, ODPB_YEAST
Q32RM2, ODPB_ZYGCRO66113, ODPB_ZYMMOP26268, ODPT_ASCSU
BRENDA1.2.4.1
MetaCyc1.2.4.1
KEGG Ligand Database for Enzyme Nomenclature1.2.4.1
EC2PDB1.2.4.1
MEDLINEFind literature relating to 1.2.4.1

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