ENZYME entry: EC 1.2.4.1

Accepted Name

pyruvate dehydrogenase (acetyl-transferring)

Alternative Name(s)

pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor- acetylating)

pyruvate decarboxylase

pyruvate dehydrogenase

pyruvate dehydrogenase (lipoamide)

pyruvate dehydrogenase complex

pyruvic acid dehydrogenase

pyruvic dehydrogenase

Reaction catalysed

H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + pyruvate = CO2 + N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase]

Comment(s)

It is a component (in multiple copies) of EC 1.2.1.104 in which it is bound to a core of molecules of EC 2.3.1.12, which also binds multiple copies of EC 1.8.1.4.
It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.12.

Cross-references

BRENDA

1.2.4.1

EC2PDB

1.2.4.1

ExplorEnz

1.2.4.1

PRIAM enzyme-specific profiles

1.2.4.1

KEGG Ligand Database for Enzyme Nomenclature

1.2.4.1

IUBMB Enzyme Nomenclature

1.2.4.1

IntEnz

1.2.4.1

MEDLINE

Find literature relating to 1.2.4.1

MetaCyc

1.2.4.1

Rhea expert-curated reactions

1.2.4.1

UniProtKB/Swiss-Prot

P10801, ODP1_AZOVI	P57301, ODP1_BUCAI	Q8K9T9, ODP1_BUCAP
Q89AR0, ODP1_BUCBP	Q8NNF6, ODP1_CORGL	Q59097, ODP1_CUPNH
P0AFG9, ODP1_ECO57	P0AFG8, ODP1_ECOLI	P45119, ODP1_HAEIN
A0R0B0, ODP1_MYCS2	P9WIS8, ODP1_MYCTO	P9WIS9, ODP1_MYCTU
Q59637, ODP1_PSEAE	P52901, ODPA1_ARATH	Q6Z5N4, ODPA1_ORYSJ
Q8H1Y0, ODPA2_ARATH	Q654V6, ODPA2_ORYSJ	O24457, ODPA3_ARATH
Q7XTJ3, ODPA3_ORYSJ	P29803, ODPAT_HUMAN	P35487, ODPAT_MOUSE
Q06437, ODPAT_RAT	P35485, ODPA_ACHLA	P26267, ODPA_ASCSU
Q4MTG0, ODPA_BACCE	P21881, ODPA_BACSU	A7MB35, ODPA_BOVIN
P52899, ODPA_CAEEL	P49823, ODPA_CANLF	G0SHF3, ODPA_CHATD
Q54C70, ODPA_DICDI	P21873, ODPA_GEOSE	P08559, ODPA_HUMAN
O13366, ODPA_KLULA	Q8HXW9, ODPA_MACFA	P35486, ODPA_MOUSE
P47516, ODPA_MYCGE	P75390, ODPA_MYCPN	Q1XDM0, ODPA_NEOYE
A5A6L0, ODPA_PANTR	P52902, ODPA_PEA	P29804, ODPA_PIG
Q5R490, ODPA_PONAB	P51267, ODPA_PORPU	P26284, ODPA_RAT
Q9R9N5, ODPA_RHIME	Q1RJX4, ODPA_RICBR	Q92IS3, ODPA_RICCN
Q4UKQ6, ODPA_RICFE	Q9ZDR4, ODPA_RICPR	Q68XA9, ODPA_RICTY
Q10489, ODPA_SCHPO	P52900, ODPA_SMIMA	P52903, ODPA_SOLTU
Q5HGZ1, ODPA_STAAC	P60089, ODPA_STAAM	Q820A6, ODPA_STAAN
Q6GHZ2, ODPA_STAAR	Q6GAC1, ODPA_STAAS	P60090, ODPA_STAAW
Q5HQ76, ODPA_STAEQ	Q8CPN3, ODPA_STAES	P16387, ODPA_YEAST
O66112, ODPA_ZYMMO	Q38799, ODPB1_ARATH	Q6Z1G7, ODPB1_ORYSJ
Q9C6Z3, ODPB2_ARATH	Q0J0H4, ODPB2_ORYSJ	O64688, ODPB3_ARATH
Q2QM55, ODPB3_ORYSJ	Q10G39, ODPB4_ORYSJ	P35488, ODPB_ACHLA
P26269, ODPB_ASCSU	P21882, ODPB_BACSU	P11966, ODPB_BOVIN
O44451, ODPB_CAEEL	Q8MA03, ODPB_CHAGL	G0RYE0, ODPB_CHATD
Q1ACL0, ODPB_CHAVU	A2CI50, ODPB_CHLAT	Q9TLS3, ODPB_CYACA
Q85FX1, ODPB_CYAM1	Q86HX0, ODPB_DICDI	Q7K5K3, ODPB_DROME
P21874, ODPB_GEOSE	Q6B8T1, ODPB_GRATL	P11177, ODPB_HUMAN
Q6ABX8, ODPB_LEIXX	P86222, ODPB_MESAU	Q9MUR4, ODPB_MESVI
Q9D051, ODPB_MOUSE	P47515, ODPB_MYCGE	P75391, ODPB_MYCPN
Q1XDM1, ODPB_NEOYE	P52904, ODPB_PEA	Q5RE79, ODPB_PONAB
P51266, ODPB_PORPU	P49432, ODPB_RAT	Q9R9N4, ODPB_RHIME
Q1RJX3, ODPB_RICBR	Q92IS2, ODPB_RICCN	Q4UKQ7, ODPB_RICFE
Q9ZDR3, ODPB_RICPR	Q68XA8, ODPB_RICTY	Q09171, ODPB_SCHPO
P81419, ODPB_SOLTU	Q5HGZ0, ODPB_STAAC	P0A0A1, ODPB_STAAM
P99063, ODPB_STAAN	Q6GHZ1, ODPB_STAAR	Q6GAC0, ODPB_STAAS
P0A0A3, ODPB_STAAU	P0A0A2, ODPB_STAAW	Q5HQ75, ODPB_STAEQ
Q8CPN2, ODPB_STAES	Q32RS0, ODPB_STAPU	P32473, ODPB_YEAST
Q32RM2, ODPB_ZYGCR	O66113, ODPB_ZYMMO	P26268, ODPT_ASCSU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.4.-
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