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ENZYME

ENZYME entry: EC 2.7.11.22

Accepted Name
cyclin-dependent kinase
Alternative Name(s)
cdc2 kinase
cdk-activating kinase
Cdk-activating protein kinase
Reaction catalysed
  • ATP + L-seryl-[protein] <=> ADP + H(+) + O-phospho-L-seryl-[protein]
  • ATP + L-threonyl-[protein] <=> ADP + H(+) + O-phospho-L-threonyl-[protein]
Comment(s)
  • Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin.
  • It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
  • Formerly EC 2.7.1.37.
Cross-references
BRENDA2.7.11.22
EC2PDB2.7.11.22
ExplorEnz2.7.11.22
PRIAM enzyme-specific profiles2.7.11.22
KEGG Ligand Database for Enzyme Nomenclature2.7.11.22
IUBMB Enzyme Nomenclature2.7.11.22
IntEnz2.7.11.22
MEDLINEFind literature relating to 2.7.11.22
MetaCyc2.7.11.22
Rhea expert-curated reactions2.7.11.22
UniProtKB/Swiss-Prot
Q75D46, BUR1_ASHGOQ4WTN5, BUR1_ASPFUQ9Y7W4, BUR1_CANAL
Q6FQ83, BUR1_CANGAQ6BV06, BUR1_DEBHAQ96VK3, BUR1_EMENI
Q4I5U9, BUR1_GIBZEQ6CRA9, BUR1_KLULAQ871M9, BUR1_NEUCR
Q6C842, BUR1_YARLIP23293, BUR1_YEASTP43568, CAK1_YEAST
P38973, CC2H1_TRYBBP54664, CC2H1_TRYCOP54665, CC2H2_TRYBB
P54666, CC2H3_TRYBBQ09437, CD111_CAEELQ23357, CD112_CAEEL
Q9UQ88, CD11A_HUMANP21127, CD11B_HUMANP24788, CD11B_MOUSE
P46892, CD11B_RATP24923, CDC21_MEDSAP19026, CDC21_PEA
Q05006, CDC22_MEDSAP28567, CDC22_PEAQ38772, CDC2A_ANTMA
Q38773, CDC2B_ANTMAQ38774, CDC2C_ANTMAQ38775, CDC2D_ANTMA
P23111, CDC2_MAIZEP93101, CDC2_OXYRBP43290, CDC2_PETHY
Q41639, CDC2_VIGACP52389, CDC2_VIGUNQ2TBL8, CDK10_BOVIN
Q55GS4, CDK10_DICDIQ15131, CDK10_HUMANQ3UMM4, CDK10_MOUSE
Q4KM47, CDK10_RATQ54RB2, CDK11_DICDID2H526, CDK12_AILME
E1BB50, CDK12_BOVINP46551, CDK12_CAEELQ9VP22, CDK12_DROME
Q9NYV4, CDK12_HUMANQ14AX6, CDK12_MOUSEQ3MJK5, CDK12_RAT
B5DE93, CDK12_XENTRE1BB52, CDK13_BOVINQ14004, CDK13_HUMAN
Q69ZA1, CDK13_MOUSEB0VXE8, CDK14_CALJAC0RW22, CDK14_DASNO
O94921, CDK14_HUMANO35495, CDK14_MOUSEB0VXL7, CDK14_PLEMO
B6A7Q3, CDK14_RABITQ6DJM7, CDK14_XENLAA4IIW7, CDK14_XENTR
Q1RLU9, CDK15_DANREQ96Q40, CDK15_HUMANQ3V3A1, CDK15_MOUSE
Q00536, CDK16_HUMANQ04735, CDK16_MOUSEQ63686, CDK16_RAT
Q8I7M8, CDK17_CAEELQ00537, CDK17_HUMANQ8K0D0, CDK17_MOUSE
O35831, CDK17_RATQ07002, CDK18_HUMANQ04899, CDK18_MOUSE
Q5RD01, CDK18_PONABO35832, CDK18_RATQ9BWU1, CDK19_HUMAN
Q8BWD8, CDK19_MOUSEP35567, CDK1A_XENLAP24033, CDK1B_XENLA
P54119, CDK1_AJECAP48734, CDK1_BOVINA8XA58, CDK1_CAEBR
P34556, CDK1_CAEELP43063, CDK1_CANALP51958, CDK1_CARAU
P13863, CDK1_CHICKP34112, CDK1_DICDIP23572, CDK1_DROME
Q00646, CDK1_EMENIQ8SR86, CDK1_ENCCUP06493, CDK1_HUMAN
P11440, CDK1_MOUSEQ9DGA5, CDK1_ORYCUQ9DGA2, CDK1_ORYJA
Q9DGD3, CDK1_ORYLAQ9DG98, CDK1_ORYLUQ5RCH1, CDK1_PONAB
Q9W739, CDK1_RANDYP39951, CDK1_RATP04551, CDK1_SCHPO
P00546, CDK1_YEASTA8WIP6, CDK20_DANREQ8IZL9, CDK20_HUMAN
Q5EDC3, CDK20_MACMUQ9JHU3, CDK20_MOUSEQ5R7I7, CDK20_PONAB
Q4KM34, CDK20_RATQ01917, CDK2H_CRIFAQ4Z6R1, CDK2H_PLABA
Q4Y4B1, CDK2H_PLACHP61075, CDK2H_PLAF7Q07785, CDK2H_PLAFK
O96821, CDK2H_PLAKHQ9XZD6, CDK2H_PLAVIQ7RM49, CDK2H_PLAYO
Q26671, CDK2H_THEANQ27032, CDK2H_THEPAQ5E9Y0, CDK2_BOVIN
O61847, CDK2_CAEELP43450, CDK2_CARAUO55076, CDK2_CRIGR
P23573, CDK2_DROMEQ04770, CDK2_ENTH1P24941, CDK2_HUMAN
P48963, CDK2_MESAUP97377, CDK2_MOUSEQ63699, CDK2_RAT
P23437, CDK2_XENLAQ00526, CDK3_HUMANQ80YP0, CDK3_MOUSE
Q32KY4, CDK4_BOVINQ9XTR1, CDK4_CAEELP11802, CDK4_HUMAN
P30285, CDK4_MOUSEP79432, CDK4_PIGP35426, CDK4_RAT
B2MVY4, CDK4_SHEEPQ91727, CDK4_XENLAP34117, CDK5_DICDI
P48609, CDK5_DROMEQ2PQN9, CDK5_GLOMMQ00534, CDK6_HUMAN
Q64261, CDK6_MOUSEG5EFV5, CDK7_CAEELP51953, CDK7_CARAU
P54685, CDK7_DICDIP50613, CDK7_HUMANQ03147, CDK7_MOUSE
P51952, CDK7_RATP20911, CDK7_XENLAQ17IE8, CDK8_AEDAE
P0C661, CDK8_CAEBRP90866, CDK8_CAEELQ8JH47, CDK8_DANRE
Q95YH0, CDK8_DICDIQ9VT57, CDK8_DROMEP49336, CDK8_HUMAN
Q8R3L8, CDK8_MOUSEQ66KH9, CDK8_XENLAQ6P3N6, CDK8_XENTR
Q4V862, CDK9A_XENLAQ7ZX42, CDK9B_XENLAQ5EAB2, CDK9_BOVIN
Q9TVL3, CDK9_CAEELQ5ZKN1, CDK9_CHICKQ7SXE8, CDK9_DANRE
P50750, CDK9_HUMANQ99J95, CDK9_MOUSEQ641Z4, CDK9_RAT
Q96WV9, CDK9_SCHPOQ6GLD8, CDK9_XENTRP24100, CDKA1_ARATH
P29618, CDKA1_ORYSJP29619, CDKA2_ORYSJQ9LFT8, CDKC1_ARATH
Q6I5Y0, CDKC1_ORYSJQ8W4P1, CDKC2_ARATHQ5JK68, CDKC2_ORYSJ
Q6ZAG3, CDKC3_ORYSJQ9C9U2, CDKD1_ARATHA2Y4B6, CDKD1_ORYSI
P29620, CDKD1_ORYSJQ9C9M7, CDKD2_ARATHQ9LMT0, CDKD3_ARATH
Q84TI6, CDKE1_ARATHQ336M2, CDKE1_ORYSJO80345, CDKF1_ARATH
A2YCH5, CDKF1_ORYSIQ5Z754, CDKF1_ORYSJQ2QSL4, CDKF2_ORYSJ
Q84SN3, CDKF3_ORYSJQ6Z8C8, CDKF4_ORYSJQ9FGW5, CDKG1_ARATH
A2X6X1, CDKG1_ORYSIQ6K5F8, CDKG1_ORYSJA2XUW1, CDKG2_ORYSI
Q7XUF4, CDKG2_ORYSJQ9U2H1, CDKL1_CAEELQ6AXJ9, CDKL1_DANRE
Q00532, CDKL1_HUMANQ8CEQ0, CDKL1_MOUSEQ66HE7, CDKL1_RAT
Q92772, CDKL2_HUMANQ4R7T5, CDKL2_MACFAQ9QUK0, CDKL2_MOUSE
Q5R754, CDKL2_PONABQ9TTK0, CDKL2_RABITQ5XIT0, CDKL2_RAT
Q8IVW4, CDKL3_HUMANQ4R8T9, CDKL3_MACFAQ8BLF2, CDKL3_MOUSE
Q9JM01, CDKL3_RATQ5MAI5, CDKL4_HUMANQ3TZA2, CDKL4_MOUSE
O76039, CDKL5_HUMANQ3UTQ8, CDKL5_MOUSEP25859, CKB11_ARATH
Q8L4P8, CKB11_ORYSJQ2V419, CKB12_ARATHQ8LF80, CKB21_ARATH
Q0J4I1, CKB21_ORYSJQ8LG64, CKB22_ARATHP36615, CSK1_SCHPO
Q9VPC0, KP58_DROMEP43294, MHK_ARATHQ9UQ07, MOK_HUMAN
Q9WVS4, MOK_MOUSEO74456, PEF1_SCHPOQ751E8, PHO85_ASHGO
Q9HGY5, PHO85_CANAXQ6FKD4, PHO85_CANGAQ6BRY2, PHO85_DEBHA
Q92241, PHO85_KLULAQ6C7U8, PHO85_YARLIP17157, PHO85_YEAST
Q751F5, SSN3_ASHGOA1CL96, SSN3_ASPCLQ4WYR6, SSN3_ASPFU
A2QU77, SSN3_ASPNCQ2UC58, SSN3_ASPORQ0CQK1, SSN3_ASPTN
Q5AHK2, SSN3_CANALQ6FKC6, SSN3_CANGAQ2GYV9, SSN3_CHAGB
Q1EBK0, SSN3_COCIMP0CS77, SSN3_CRYNBP0CS76, SSN3_CRYNJ
Q6BM25, SSN3_DEBHAQ5BAE1, SSN3_EMENIQ4FCZ5, SSN3_GIBMO
Q6CR51, SSN3_KLULAA4QXX4, SSN3_MAGO7A1D624, SSN3_NEOFI
Q0TWJ7, SSN3_PHANOA3LUB9, SSN3_PICSTO13958, SSN3_SCHPO
Q4P9T2, SSN3_USTMAQ6CCB0, SSN3_YARLIP39073, SSN3_YEAST
Q54D75, Y2550_DICDIQ556J6, Y4007_DICDIQ55FJ6, Y8078_DICDI
Q8SRF5, Y823_ENCCUQ54Y06, Y8487_DICDIQ8SR90, Y8H9_ENCCU
Q8SQU8, YBC9_ENCCU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-