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ENZYME

ENZYME entry: EC 2.7.11.25

Accepted Name
mitogen-activated protein kinase kinase kinase
Alternative Name(s)
MAP3K
MAP kinase kinase kinase
MAPKKK
MEKK
MEK kinase
MLK-like mitogen-activated protein triple kinase
MLTK
Reaction catalysed
  • ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
  • ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Comment(s)
  • This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, but requires MAPKKKK for activation.
  • Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras.
  • While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway.
  • Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation.
  • Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.
  • Formerly EC 2.7.1.37.
Cross-references
BRENDA2.7.11.25
EC2PDB2.7.11.25
ExplorEnz2.7.11.25
PRIAM enzyme-specific profiles2.7.11.25
KEGG Ligand Database for Enzyme Nomenclature2.7.11.25
IUBMB Enzyme Nomenclature2.7.11.25
IntEnz2.7.11.25
MEDLINEFind literature relating to 2.7.11.25
MetaCyc2.7.11.25
Rhea expert-curated reactions2.7.11.25
UniProtKB/Swiss-Prot
O22040, ANP1_ARATHP28829, BYR2_SCHPOA8X775, DLK1_CAEBR
O01700, DLK1_CAEELA7J1T2, M313A_XENLAA7J1T0, M313B_XENLA
Q02779, M3K10_HUMANQ66L42, M3K10_MOUSED3ZG83, M3K10_RAT
Q7T2V3, M3K10_XENLAQ16584, M3K11_HUMANQ80XI6, M3K11_MOUSE
Q66HA1, M3K11_RATQ12852, M3K12_HUMANQ60700, M3K12_MOUSE
Q63796, M3K12_RATA7MBB4, M3K13_BOVINO43283, M3K13_HUMAN
Q1HKZ5, M3K13_MOUSEQ5R8X7, M3K13_PONABQ99558, M3K14_HUMAN
Q9WUL6, M3K14_MOUSEQ6ZN16, M3K15_HUMANA2AQW0, M3K15_MOUSE
O80888, M3K17_ARATHQ9ZVP5, M3K18_ARATHA9SY39, M3K1A_PHYPA
A9RVK2, M3K1B_PHYPAQ39008, M3K1_ARATHQ13233, M3K1_HUMAN
P53349, M3K1_MOUSEQ62925, M3K1_RATQ9SND6, M3K20_ARATH
H2KZW3, M3K20_CAEELQ9NYL2, M3K20_HUMANQ9ESL4, M3K20_MOUSE
Q5TCX8, M3K21_HUMANQ8VDG6, M3K21_MOUSEQ9FZ36, M3K2_ARATH
Q9Y2U5, M3K2_HUMANQ61083, M3K2_MOUSEF4HRJ4, M3K3A_ARATH
O22042, M3K3_ARATHQ99759, M3K3_HUMANQ61084, M3K3_MOUSE
Q9Y6R4, M3K4_HUMANO08648, M3K4_MOUSEQ9C5H5, M3K5G_ARATH
Q99683, M3K5_HUMANO35099, M3K5_MOUSEO95382, M3K6_HUMAN
Q9WTR2, M3K6_MOUSEP83104, M3K7L_DROMEA2VDU3, M3K7_BOVIN
Q9V3Q6, M3K7_DROMEO43318, M3K7_HUMANQ62073, M3K7_MOUSE
Q5RFL3, M3K7_PONABP0C8E4, M3K7_RATP41279, M3K8_HUMAN
Q07174, M3K8_MOUSEQ63562, M3K8_RATP80192, M3K9_HUMAN
Q3U1V8, M3K9_MOUSEQ95UN8, M3KSL_DROMEQ10407, MKH1_SCHPO
Q54R82, MKKA_DICDIA0A0K3AV08, MLK1_CAEELA8WWX1, MOM4_CAEBR
Q9XTC6, MOM4_CAEELQ9M0T3, MP3K3_ARATHQ40541, NPK1_TOBAC
Q21029, NSY1_CAEELP53599, SSK2_YEASTB5VNQ3, STE11_YEAS6
A7A1P0, STE11_YEAS7P23561, STE11_YEASTO74304, WIN1_SCHPO
O14299, WIS4_SCHPOQ9CAD5, YODA_ARATH

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