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ENZYME entry: EC 2.7.11.25

Accepted Name
mitogen-activated protein kinase kinase kinase.
Alternative Name(s)
MAP3K.
MAP kinase kinase kinase.
MAPKKK.
MEKK.
MEK kinase.
MLK-like mitogen-activated protein triple kinase.
MLTK.
Reaction catalysed
  • ATP + L-seryl-[protein] <=> ADP + H(+) + O-phospho-L-seryl-[protein]
  • ATP + L-threonyl-[protein] <=> ADP + H(+) + O-phospho-L-threonyl-[protein]
Comment(s)
  • This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, but requires MAPKKKK for activation.
  • Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras.
  • While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway.
  • Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation.
  • Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.
  • Formerly EC 2.7.1.37.
Cross-references
BRENDA2.7.11.25
EC2PDB2.7.11.25
ExplorEnz2.7.11.25
PRIAM enzyme-specific profiles2.7.11.25
KEGG Ligand Database for Enzyme Nomenclature2.7.11.25
IUBMB Enzyme Nomenclature2.7.11.25
IntEnz2.7.11.25
MEDLINEFind literature relating to 2.7.11.25
MetaCyc2.7.11.25
Rhea expert-curated reactions2.7.11.25
UniProtKB/Swiss-Prot
O22040, ANP1_ARATH;  P28829, BYR2_SCHPO;  A8X775, DLK1_CAEBR;  
O01700, DLK1_CAEEL;  A7J1T2, M313A_XENLA;  A7J1T0, M313B_XENLA;  
Q02779, M3K10_HUMAN;  Q66L42, M3K10_MOUSE;  D3ZG83, M3K10_RAT;  
Q7T2V3, M3K10_XENLA;  Q16584, M3K11_HUMAN;  Q80XI6, M3K11_MOUSE;  
Q66HA1, M3K11_RAT;  Q12852, M3K12_HUMAN;  Q60700, M3K12_MOUSE;  
Q63796, M3K12_RAT;  A7MBB4, M3K13_BOVIN;  O43283, M3K13_HUMAN;  
Q1HKZ5, M3K13_MOUSE;  Q5R8X7, M3K13_PONAB;  Q99558, M3K14_HUMAN;  
Q9WUL6, M3K14_MOUSE;  Q6ZN16, M3K15_HUMAN;  A2AQW0, M3K15_MOUSE;  
O80888, M3K17_ARATH;  Q9ZVP5, M3K18_ARATH;  A9SY39, M3K1A_PHYPA;  
A9RVK2, M3K1B_PHYPA;  Q39008, M3K1_ARATH;  Q13233, M3K1_HUMAN;  
P53349, M3K1_MOUSE;  Q62925, M3K1_RAT;  Q9SND6, M3K20_ARATH;  
H2KZW3, M3K20_CAEEL;  Q9NYL2, M3K20_HUMAN;  Q9ESL4, M3K20_MOUSE;  
Q5TCX8, M3K21_HUMAN;  Q8VDG6, M3K21_MOUSE;  Q9FZ36, M3K2_ARATH;  
Q9Y2U5, M3K2_HUMAN;  Q61083, M3K2_MOUSE;  F4HRJ4, M3K3A_ARATH;  
O22042, M3K3_ARATH;  Q99759, M3K3_HUMAN;  Q61084, M3K3_MOUSE;  
Q9Y6R4, M3K4_HUMAN;  O08648, M3K4_MOUSE;  Q9C5H5, M3K5G_ARATH;  
Q99683, M3K5_HUMAN;  O35099, M3K5_MOUSE;  O95382, M3K6_HUMAN;  
Q9WTR2, M3K6_MOUSE;  P83104, M3K7L_DROME;  A2VDU3, M3K7_BOVIN;  
Q9V3Q6, M3K7_DROME;  O43318, M3K7_HUMAN;  Q62073, M3K7_MOUSE;  
Q5RFL3, M3K7_PONAB;  P0C8E4, M3K7_RAT;  P41279, M3K8_HUMAN;  
Q07174, M3K8_MOUSE;  Q63562, M3K8_RAT;  P80192, M3K9_HUMAN;  
Q3U1V8, M3K9_MOUSE;  Q95UN8, M3KSL_DROME;  Q10407, MKH1_SCHPO;  
Q54R82, MKKA_DICDI;  A0A0K3AV08, MLK1_CAEEL;  A8WWX1, MOM4_CAEBR;  
Q9XTC6, MOM4_CAEEL;  Q9M0T3, MP3K3_ARATH;  Q40541, NPK1_TOBAC;  
Q21029, NSY1_CAEEL;  P53599, SSK2_YEAST;  B5VNQ3, STE11_YEAS6;  
A7A1P0, STE11_YEAS7;  P23561, STE11_YEAST;  O74304, WIN1_SCHPO;  
O14299, WIS4_SCHPO;  Q9CAD5, YODA_ARATH;  

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