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ENZYME

ENZYME entry: EC 2.7.12.2

PURL: https://purl.expasy.org/enzyme/EC/2.7.12.2
Accepted Name
mitogen-activated protein kinase kinase
Alternative Name(s)
MAP2K
MAP kinase kinase
MAPKK
MEK
MKK
Reaction catalysed
  • L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)
  • L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)
  • L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)
Comment(s)
  • A dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation.
  • It is required for activation of EC 2.7.11.24.
  • Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues.
  • Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation.
  • Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.
Cross-references
BRENDA2.7.12.2
EC2PDB2.7.12.2
ExplorEnz2.7.12.2
KEGG Ligand Database for Enzyme Nomenclature2.7.12.2
IUBMB Enzyme Nomenclature2.7.12.2
MEDLINEFind literature relating to 2.7.12.2
MetaCyc2.7.12.2
Rhea expert-curated reactions2.7.12.2
UniProtKB/Swiss-Prot
P10506, BYR1_SCHPOQ24324, DSOR1_DROMEQ99078, FUZ7_MYCMD
Q23977, HEP_DROMEG5EDT6, JKK1_CAEELQ9LQM8, M2K10_ARATH
A9RWC9, M2K1A_PHYPAA9SR33, M2K1B_PHYPAA9S5R3, M2K1C_PHYPA
Q94A06, M2K1_ARATHQ5QN75, M2K1_ORYSJQ9S7U9, M2K2_ARATH
O80396, M2K3_ARATHO80397, M2K4_ARATHQ8RXG3, M2K5_ARATH
Q9FJV0, M2K6_ARATHQ9LPQ3, M2K7_ARATHQ9M8J5, M2K8_ARATH
Q9FX43, M2K9_ARATHQ21307, MEK1_CAEELQ10664, MEK2_CAEEL
P32490, MKK1_YEASTP32491, MKK2_YEASTQ20347, MKK4_CAEEL
Q9GRT1, MKK4_LEIMEQ0PKV7, MKK5_LEIMEQ63980, MP2K1_CRIGR
Q55CL6, MP2K1_DICDIQ02750, MP2K1_HUMANP31938, MP2K1_MOUSE
Q9XT09, MP2K1_PANTRP29678, MP2K1_RABITQ01986, MP2K1_RAT
Q91447, MP2K1_SERCAQ05116, MP2K1_XENLAQ1HG70, MP2K2_CANLF
Q90891, MP2K2_CHICKQ90321, MP2K2_CYPCAP36507, MP2K2_HUMAN
Q63932, MP2K2_MOUSEP36506, MP2K2_RATQ07192, MP2K2_XENLA
P46734, MP2K3_HUMANO09110, MP2K3_MOUSEP39746, MP2K3_XENLA
P45985, MP2K4_HUMANP47809, MP2K4_MOUSEQ13163, MP2K5_HUMAN
Q9WVS7, MP2K5_MOUSEQ62862, MP2K5_RATQ5E9X2, MP2K6_BOVIN
Q9DGE0, MP2K6_DANREP52564, MP2K6_HUMANP70236, MP2K6_MOUSE
O14733, MP2K7_HUMANQ8CE90, MP2K7_MOUSEQ4KSH7, MP2K7_RAT
Q84VX4, MPS1_ARATHQ8SSH4, MPS1_ENCCUP54199, MPS1_YEAST
P08018, PBS2_YEASTG5EDF7, SEK1_CAEELA0A1S4CGX4, SIPKK_TOBAC
A0A1S3Z5Y0, SIPK_TOBACQ9Y884, SKH1_SCHPOQ5A6T5, STE7_CANAL
C4YLK8, STE7_CANAWP0CY25, STE7_CANAXP06784, STE7_YEAST
Q6DHU8, TOPK_DANREQ96KB5, TOPK_HUMANQ9JJ78, TOPK_MOUSE
P33886, WIS1_SCHPO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.12.-
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