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ENZYME

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ENZYME entry: EC 2.7.11.26

Accepted Name
[tau protein] kinase
Alternative Name(s)
[tau-protein] kinase
glycogen synthase kinase-3beta
GSK
protein tau kinase
tau kinase
tau-tubulin kinase
TPK
TTK
Reaction catalysed
  • ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein]
  • ATP + L-threonyl-[tau protein] = ADP + H(+) + O-phospho-L-threonyl-[tau protein]
Comment(s)
  • Activated by tubulin.
  • Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.
  • Formerly EC 2.7.1.135.
Cross-references
BRENDA2.7.11.26
EC2PDB2.7.11.26
ExplorEnz2.7.11.26
PRIAM enzyme-specific profiles2.7.11.26
KEGG Ligand Database for Enzyme Nomenclature2.7.11.26
IUBMB Enzyme Nomenclature2.7.11.26
IntEnz2.7.11.26
MEDLINEFind literature relating to 2.7.11.26
MetaCyc2.7.11.26
Rhea expert-curated reactions2.7.11.26
UniProtKB/Swiss-Prot
Q13131, AAPK1_HUMANQ5EG47, AAPK1_MOUSEQ09136, AAPK1_PIG
Q5RDH5, AAPK1_PONABP54645, AAPK1_RATQ8TDC3, BRSK1_HUMAN
Q5RJI5, BRSK1_MOUSEB2DD29, BRSK1_RATQ8IWQ3, BRSK2_HUMAN
Q69Z98, BRSK2_MOUSED3ZML2, BRSK2_RATQ55C57, GLKA_DICDI
P49840, GSK3A_HUMANQ2NL51, GSK3A_MOUSEP18265, GSK3A_RAT
P49841, GSK3B_HUMANQ9WV60, GSK3B_MOUSEP18266, GSK3B_RAT
Q5YJC2, GSK3B_SPECIQ388M1, GSK3B_TRYB2Q91757, GSK3B_XENLA
P83101, GSK3H_DROMEA8X5H5, GSK3_CAEBRQ9U2Q9, GSK3_CAEEL
P51136, GSK3_DICDIP35508, KC1D_BOVINP48730, KC1D_HUMAN
Q9DC28, KC1D_MOUSEQ5RC72, KC1D_PONABP81123, KC1D_RABIT
Q06486, KC1D_RATQ5BP74, KC1D_XENLAQ6P647, KC1D_XENTR
Q9P0L2, MARK1_HUMANQ8VHJ5, MARK1_MOUSEO08678, MARK1_RAT
Q7KZI7, MARK2_HUMANQ05512, MARK2_MOUSEO08679, MARK2_RAT
Q16816, PHKG1_HUMANP07934, PHKG1_MOUSEP00518, PHKG1_RABIT
P13286, PHKG1_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-