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ENZYME

ENZYME entry: EC 2.7.11.27

Accepted Name
[acetyl-CoA carboxylase] kinase
Alternative Name(s)
acetyl-CoA carboxylase bound kinase
acetyl-CoA carboxylase kinase
acetyl-CoA carboxylase kinase (AMP-activated)
acetyl-CoA carboxylase kinase (cAMP-independent)
acetyl-coenzyme A carboxylase kinase
acetyl coenzyme A carboxylase kinase (phosphorylating)
AMPK
I-peptide kinase
Reaction catalysed
ATP + L-seryl-[acetyl-CoA carboxylase] <=> ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase]
Comment(s)
  • Phosphorylates and inactivates EC 6.4.1.2, which can be dephosphorylated and reactivated by EC 3.1.3.17.
  • More active toward the dimeric form of acetyl-CoA carboxylase than the polymeric form.
  • Phosphorylates serine residues.
  • Formerly EC 2.7.1.111 and EC 2.7.1.128.
Cross-references
BRENDA2.7.11.27
EC2PDB2.7.11.27
ExplorEnz2.7.11.27
PRIAM enzyme-specific profiles2.7.11.27
KEGG Ligand Database for Enzyme Nomenclature2.7.11.27
IUBMB Enzyme Nomenclature2.7.11.27
IntEnz2.7.11.27
MEDLINEFind literature relating to 2.7.11.27
MetaCyc2.7.11.27
Rhea expert-curated reactions2.7.11.27
UniProtKB/Swiss-Prot
Q13131, AAPK1_HUMANQ5EG47, AAPK1_MOUSEQ09136, AAPK1_PIG
Q5RDH5, AAPK1_PONABP54645, AAPK1_RATP54646, AAPK2_HUMAN
Q8BRK8, AAPK2_MOUSEQ28948, AAPK2_PIGQ5RD00, AAPK2_PONAB
Q09137, AAPK2_RAT

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