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ENZYME

ENZYME entry: EC 2.7.11.36

PURL: https://purl.expasy.org/enzyme/EC/2.7.11.36
Accepted Name
MASTL-subfamily protein kinase
Alternative Name(s)
greatwall kinase
MASTL
microtubule-associated-subfamily-protein kinase
Reaction catalysed
  • L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)
  • L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)
Comment(s)
  • Requires Mg(2+).
  • Peptide array data suggest that MASTL prefers to phosphorylate Ser over Thr, followed at position +1 by a bulky hydrophobic (Met, Leu, Phe or Tyr) and with an aromatic residue in the -2 position.
  • Its main role in animal systems is in the regulation of mitosis by phosphorylating a conserved site on endosulfine family proteins (ENSA and ARPP-19 in human), causing them to inhibit the protein phosphatase 2A-B55 [protein phosphatase 2A (PP2A) holoenzyme complex containing a B55-family regulatory subunit].
Cross-references
BRENDA2.7.11.36
EC2PDB2.7.11.36
ExplorEnz2.7.11.36
KEGG Ligand Database for Enzyme Nomenclature2.7.11.36
IUBMB Enzyme Nomenclature2.7.11.36
MEDLINEFind literature relating to 2.7.11.36
MetaCyc2.7.11.36
Rhea expert-curated reactions2.7.11.36

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
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