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ENZYME

ENZYME entry: EC 2.7.11.38

PURL: https://purl.expasy.org/enzyme/EC/2.7.11.38
Accepted Name
NEK9 subfamily protein kinase
Reaction catalysed
  • L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)
  • L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)
Comment(s)
  • This enzyme is found in animals and choanoflagellates, although it has been lost in arthropods and nematodes. It is implicated in centrosome separation and cilium formation.
  • In peptide arrays, the enzyme prefers to phosphorylate Ser, with acidic residues at -2 and -4/-5, similar to that of the NEK6 protein kinase subfamily. NEK9 can autophosphorylate.
  • Substrates in humans include the microtubule-associated protein kinases NEK6/7, the microtubule-associated protein spindle assembly protein TPX2, the gamma-tubulin associated protein NEDD1, which is required for mitotic spindle assembly and function and the LC3B protein, which is involved in autophagy substrate selection and autophagosome biogenesis.
Cross-references
BRENDA2.7.11.38
EC2PDB2.7.11.38
ExplorEnz2.7.11.38
KEGG Ligand Database for Enzyme Nomenclature2.7.11.38
IUBMB Enzyme Nomenclature2.7.11.38
MEDLINEFind literature relating to 2.7.11.38
MetaCyc2.7.11.38
Rhea expert-curated reactions2.7.11.38
UniProtKB/Swiss-Prot
Q8TD19, NEK9_HUMANQ8K1R7, NEK9_MOUSEQ7ZZC8, NEK9_XENLA

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