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ENZYME

ENZYME entry: EC 2.7.12.1

Accepted Name
dual-specificity kinase
Reaction catalysed
  • ATP + L-seryl-[protein] <=> ADP + H(+) + O-phospho-L-seryl-[protein]
  • ATP + L-threonyl-[protein] <=> ADP + H(+) + O-phospho-L-threonyl-[protein]
  • ATP + L-tyrosyl-[protein] <=> ADP + H(+) + O-phospho-L-tyrosyl-[protein]
Comment(s)
  • This family of enzymes can phosphorylate both Ser/Thr and Tyr residues.
  • Formerly EC 2.7.1.37.
Cross-references
BRENDA2.7.12.1
EC2PDB2.7.12.1
ExplorEnz2.7.12.1
PRIAM enzyme-specific profiles2.7.12.1
KEGG Ligand Database for Enzyme Nomenclature2.7.12.1
IUBMB Enzyme Nomenclature2.7.12.1
IntEnz2.7.12.1
MEDLINEFind literature relating to 2.7.12.1
MetaCyc2.7.12.1
Rhea expert-curated reactions2.7.12.1
UniProtKB/Swiss-Prot
P51566, AFC1_ARATHP51567, AFC2_ARATHP51568, AFC3_ARATH
P49759, CLK1_HUMANP22518, CLK1_MOUSEP49760, CLK2_HUMAN
O35491, CLK2_MOUSEQ3SX21, CLK3_BOVINP49761, CLK3_HUMAN
O35492, CLK3_MOUSEQ63117, CLK3_RATQ9HAZ1, CLK4_HUMAN
O35493, CLK4_MOUSEP49762, DOA_DROMEQ1L6Q1, DUSTY_APIME
Q4TVR5, DUSTY_BOVINQ4VSN4, DUSTY_CANLFQ6XUX0, DUSTY_CHICK
Q4VSN1, DUSTY_DANREQ6XUX3, DUSTY_HUMANQ20CR4, DUSTY_MACMU
Q6XUX1, DUSTY_MOUSEQ4VSN5, DUSTY_PANTRA2CI34, DUSTY_PIMPR
Q6XUX2, DUSTY_RATA2CI35, DUSTY_STRPUQ4VSN2, DUSTY_TAKRU
Q4VSN3, DUSTY_TETNGQ67E01, DUSTY_XENLAQ67E00, DUSTY_XENTR
Q13627, DYR1A_HUMANQ61214, DYR1A_MOUSEP85051, DYR1A_RABIT
Q63470, DYR1A_RATQ2TAE3, DYR1A_XENLAQ0IJ08, DYR1A_XENTR
Q9Y463, DYR1B_HUMANQ9Z188, DYR1B_MOUSEQ76NV1, DYRK1_DICDI
Q5ZIU3, DYRK2_CHICKQ54BC9, DYRK2_DICDIQ9V3D5, DYRK2_DROME
Q92630, DYRK2_HUMANQ5U4C9, DYRK2_MOUSEP83102, DYRK3_DROME
O43781, DYRK3_HUMANQ4R6S5, DYRK3_MACFAQ922Y0, DYRK3_MOUSE
Q4V8A3, DYRK3_RATQ9NR20, DYRK4_HUMANQ8BI55, DYRK4_MOUSE
P32350, KNS1_YEASTQ10156, LKH1_SCHPOA8X4H1, MBK1_CAEBR
Q8WQL7, MBK1_CAEELA8WJR8, MBK2_CAEBRQ9XTF3, MBK2_CAEEL
P21965, MCK1_YEASTP49657, MNB_DROMEO94235, MPH1L_SCHPO
Q09690, POM1_SCHPOQ54I36, PYK3_DICDIP22216, RAD53_YEAST
O64782, SD129_ARATHA2XW02, STRK1_ORYSIQ7XR88, STRK1_ORYSJ
Q15569, TESK1_HUMANO70146, TESK1_MOUSEQ63572, TESK1_RAT
Q96S53, TESK2_HUMANQ8VCT9, TESK2_MOUSEQ924U5, TESK2_RAT
Q8AYG3, TTK_DANREP33981, TTK_HUMANQ4R945, TTK_MACFA
P35761, TTK_MOUSEQ8RWH3, YAK1_ARATHQ8SQZ4, YAK1_ENCCU
P14680, YAK1_YEASTQ54QV3, YAKA_DICDIQ75JK0, ZAK1_DICDI
Q552C6, ZAK2_DICDI

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.12.-
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