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ENZYME entry: EC 2.7.4.14

Accepted Name
UMP/CMP kinase.
Alternative Name(s)
CMP kinase.
Cytidine monophosphate kinase.
Cytidylate kinase.
dCMP kinase.
Deoxycytidine kinase.
Deoxycytidylate kinase.
UMP-CMP kinase.
Uridine monophosphate-cytidine monophosphate phosphotransferase.
Reaction catalysed
  • ATP + (d)CMP <=> ADP + (d)CDP
  • ATP + UMP <=> ADP + UDP
Comment(s)
  • This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency.
  • dCMP can also act as acceptor.
  • Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, (d)CMP kinase and EC 2.7.4.22, UMP kinase.
  • This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency.
  • dCMP can also act as acceptor.
  • Different from the monofunctional prokaryotic enzymes EC 2.7.4.25 and EC 2.7.4.22.
  • Formerly EC 2.7.4.5.
Cross-references
PROSITEPDOC00104
BRENDA2.7.4.14
EC2PDB2.7.4.14
ExplorEnz2.7.4.14
PRIAM enzyme-specific profiles2.7.4.14
KEGG Ligand Database for Enzyme Nomenclature2.7.4.14
IUBMB Enzyme Nomenclature2.7.4.14
IntEnz2.7.4.14
MEDLINEFind literature relating to 2.7.4.14
MetaCyc2.7.4.14
Rhea expert-curated reactions2.7.4.14
UniProtKB/Swiss-Prot
Q5EBM0, CMPK2_HUMAN;  Q3U5Q7, CMPK2_MOUSE;  Q8VY84, KCY1_ARATH;  
O17622, KCY1_CAEEL;  Q5VRN0, KCY1_ORYSJ;  Q6NMK6, KCY2_ARATH;  
Q20230, KCY2_CAEEL;  Q7XMI0, KCY2_ORYSJ;  O04905, KCY3_ARATH;  
Q7XI40, KCY3_ORYSJ;  Q6K7H2, KCY4_ORYSJ;  Q2KIW9, KCY_BOVIN;  
Q5ZKE7, KCY_CHICK;  Q7ZWE9, KCY_DANRE;  P20425, KCY_DICDI;  
P30085, KCY_HUMAN;  O59845, KCY_LENED;  Q9DBP5, KCY_MOUSE;  
Q29561, KCY_PIG;  O24464, KCY_PRUAR;  Q4KM73, KCY_RAT;  
O59771, KCY_SCHPO;  Q7ZX23, KCY_XENLA;  Q28H12, KCY_XENTR;  
P15700, KCY_YEAST;  

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