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ENZYME

ENZYME entry: EC 2.7.4.14

Accepted Name
UMP/CMP kinase
Alternative Name(s)
CMP kinase
cytidine monophosphate kinase
cytidylate kinase
dCMP kinase
deoxycytidine kinase
deoxycytidylate kinase
UMP-CMP kinase
uridine monophosphate-cytidine monophosphate phosphotransferase
Reaction catalysed
  • ATP + CMP <=> ADP + CDP
  • ATP + dCMP <=> ADP + dCDP
  • ATP + UMP <=> ADP + UDP
Comment(s)
  • This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency.
  • dCMP can also act as acceptor.
  • Different from the monofunctional prokaryotic enzymes EC 2.7.4.25 and EC 2.7.4.22.
  • Formerly EC 2.7.4.5.
Cross-references
BRENDA2.7.4.14
EC2PDB2.7.4.14
ExplorEnz2.7.4.14
PRIAM enzyme-specific profiles2.7.4.14
KEGG Ligand Database for Enzyme Nomenclature2.7.4.14
IUBMB Enzyme Nomenclature2.7.4.14
IntEnz2.7.4.14
MEDLINEFind literature relating to 2.7.4.14
MetaCyc2.7.4.14
Rhea expert-curated reactions2.7.4.14
UniProtKB/Swiss-Prot
Q5EBM0, CMPK2_HUMANQ3U5Q7, CMPK2_MOUSEQ8VY84, KCY1_ARATH
O17622, KCY1_CAEELQ5VRN0, KCY1_ORYSJQ6NMK6, KCY2_ARATH
Q20230, KCY2_CAEELQ7XMI0, KCY2_ORYSJO04905, KCY3_ARATH
Q7XI40, KCY3_ORYSJQ6K7H2, KCY4_ORYSJQ2KIW9, KCY_BOVIN
Q5ZKE7, KCY_CHICKQ7ZWE9, KCY_DANREP20425, KCY_DICDI
P30085, KCY_HUMANO59845, KCY_LENEDQ9DBP5, KCY_MOUSE
Q29561, KCY_PIGO24464, KCY_PRUARQ4KM73, KCY_RAT
O59771, KCY_SCHPOQ7ZX23, KCY_XENLAQ28H12, KCY_XENTR
P15700, KCY_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-