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ENZYME

ENZYME entry: EC 2.7.4.22

Accepted Name
UMP kinase
Alternative Name(s)
UMPK
UMP-kinase
uridine monophosphate kinase
uridylate kinase
Reaction catalysed
UMP + ATP = UDP + ADP
Comment(s)
  • Strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme EC 2.7.4.14 for the same purpose.
  • Subject of feedback regulation, being inhibited by UTP and activated by GTP.
Cross-references
BRENDA2.7.4.22
EC2PDB2.7.4.22
ExplorEnz2.7.4.22
KEGG Ligand Database for Enzyme Nomenclature2.7.4.22
IUBMB Enzyme Nomenclature2.7.4.22
MEDLINEFind literature relating to 2.7.4.22
MetaCyc2.7.4.22
Rhea expert-curated reactions2.7.4.22
UniProtKB/Swiss-Prot
Q9LSA9, PUMPK_ARATHA3DE57, PYRH_ACET2Q6FCH3, PYRH_ACIAD
A3M658, PYRH_ACIBTA0LV52, PYRH_ACIC1A5G1L2, PYRH_ACICJ
A1W916, PYRH_ACISJA3MZT5, PYRH_ACTP2A6VM31, PYRH_ACTSZ
A0KHG5, PYRH_AERHHQ9YF40, PYRH_AERPEA4SQI0, PYRH_AERS4
Q8UFM1, PYRH_AGRFCQ21WY7, PYRH_ALBFTQ0VQF5, PYRH_ALCBS
A8ESI8, PYRH_ALIB4Q5E3E1, PYRH_ALIF1Q0A7I2, PYRH_ALKEH
A6TRM1, PYRH_ALKMQA8MHH1, PYRH_ALKOOQ2IMM2, PYRH_ANADE
A7H724, PYRH_ANADFQ5PBQ6, PYRH_ANAMMQ2GLL2, PYRH_ANAPZ
O66929, PYRH_AQUAEO28237, PYRH_ARCFUQ5NZH3, PYRH_AROAE
A0JUP3, PYRH_ARTS2Q2NIS4, PYRH_AYWBPA8I467, PYRH_AZOC5
A1K6R9, PYRH_AZOSBQ81WL0, PYRH_BACANQ819Y0, PYRH_BACCR
Q5LHK5, PYRH_BACFNQ64YI2, PYRH_BACFRQ65JJ7, PYRH_BACLD
O31749, PYRH_BACSUQ8A5J7, PYRH_BACTNA7Z4S2, PYRH_BACVZ
Q8RT65, PYRH_BARBKQ6G5C7, PYRH_BARHEQ6FZN2, PYRH_BARQU
Q1LSV5, PYRH_BAUCHQ6MGY5, PYRH_BDEBAA1A1I1, PYRH_BIFAA
Q8G484, PYRH_BIFLOQ7VRE4, PYRH_BLOFLQ493D0, PYRH_BLOPB
Q2L160, PYRH_BORA1Q7WJ92, PYRH_BORBRQ7WA58, PYRH_BORPA
Q7VYC8, PYRH_BORPEQ89KP5, PYRH_BRADUA5EK53, PYRH_BRASB
A4YVG4, PYRH_BRASOA6X0J3, PYRH_BRUA4Q57CX9, PYRH_BRUAB
Q8YHH4, PYRH_BRUMEQ8G0D7, PYRH_BRUSUP57327, PYRH_BUCAI
P59002, PYRH_BUCAPP59578, PYRH_BUCBPQ057S9, PYRH_BUCCC
A0K8E1, PYRH_BURCHQ0BE17, PYRH_BURCMQ39F45, PYRH_BURL3
A3MKU1, PYRH_BURM7A2SB74, PYRH_BURM9Q62JC6, PYRH_BURMA
A1V567, PYRH_BURMSQ1BHI0, PYRH_BURO1A3NWM9, PYRH_BURP0
Q3JR30, PYRH_BURP1A3NAU6, PYRH_BURP6Q63T14, PYRH_BURPS
Q2SWZ6, PYRH_BURTAA4JF73, PYRH_BURVGQ8RA23, PYRH_CALS4
A4XM00, PYRH_CALS8A7ZEY4, PYRH_CAMC1A7GXE5, PYRH_CAMC5
A0RQ89, PYRH_CAMFFA7I2U3, PYRH_CAMHCA8FMY0, PYRH_CAMJ8
A7H2A6, PYRH_CAMJDQ9PN24, PYRH_CAMJEA1W0Q9, PYRH_CAMJJ
Q5HTI9, PYRH_CAMJRQ3AB79, PYRH_CARHZQ9A705, PYRH_CAUVC
A0RXT6, PYRH_CENSYA3PJF6, PYRH_CERS1Q3J2X5, PYRH_CERS4
A4WUH9, PYRH_CERS5Q11IJ6, PYRH_CHESBQ5L765, PYRH_CHLAB
Q3AQ27, PYRH_CHLCHQ824U5, PYRH_CHLCVQ252Q5, PYRH_CHLFF
Q3B5T8, PYRH_CHLL3P71147, PYRH_CHLMUA1BHZ3, PYRH_CHLPD
Q9Z7K7, PYRH_CHLPNQ3KL16, PYRH_CHLTAP59003, PYRH_CHLTE
O84685, PYRH_CHLTRA0LXJ4, PYRH_CHRFKQ1R031, PYRH_CHRSD
Q7NVZ2, PYRH_CHRVOA8ALB8, PYRH_CITK8A5CQS6, PYRH_CLAM3
Q97I64, PYRH_CLOABA7FPZ6, PYRH_CLOB1A5I4L0, PYRH_CLOBH
A7GG21, PYRH_CLOBLQ185S7, PYRH_CLOD6A0Q0R8, PYRH_CLONN
Q0TPQ5, PYRH_CLOP1Q8XJQ8, PYRH_CLOPEQ0SSC2, PYRH_CLOPS
Q895L0, PYRH_CLOTEQ485G8, PYRH_COLP3Q6NGK6, PYRH_CORDI
Q8FP74, PYRH_COREFA4QF30, PYRH_CORGBP59004, PYRH_CORGL
Q4JV20, PYRH_CORJKQ83BV3, PYRH_COXBUA7MGT0, PYRH_CROS8
Q1LNF6, PYRH_CUPMCQ0KA18, PYRH_CUPNHQ470D9, PYRH_CUPPJ
Q6A7J9, PYRH_CUTAKQ11XK2, PYRH_CYTH3Q47F90, PYRH_DECAR
Q3Z9H8, PYRH_DEHM1Q3ZZC3, PYRH_DEHMCQ1IZI8, PYRH_DEIGD
Q9RU81, PYRH_DEIRAQ24UF9, PYRH_DESHYQ6AP39, PYRH_DESPS
A4J5Z1, PYRH_DESRMA5EV27, PYRH_DICNVA7ZHR1, PYRH_ECO24
P0A7F1, PYRH_ECO57A7ZWB7, PYRH_ECOHSA1A7L5, PYRH_ECOK1
Q0TLG2, PYRH_ECOL5P0A7F0, PYRH_ECOL6P0A7E9, PYRH_ECOLI
Q1RG18, PYRH_ECOUTA4XWT9, PYRH_ECTM1Q3YR64, PYRH_EHRCJ
Q2GHJ6, PYRH_EHRCRQ5FG65, PYRH_EHRRGQ5HAF8, PYRH_EHRRW
A4W6R6, PYRH_ENT38Q831V1, PYRH_ENTFAQ2NBU2, PYRH_ERYLH
A7HL98, PYRH_FERNBA6GWS3, PYRH_FLAPJQ0RBL9, PYRH_FRAAA
Q2J528, PYRH_FRACCQ14JD0, PYRH_FRAT1A7N9R6, PYRH_FRATF
Q2A5I0, PYRH_FRATHA0Q4H3, PYRH_FRATNQ0BNT7, PYRH_FRATO
Q5NHX8, PYRH_FRATTA4IZU4, PYRH_FRATWQ8R6G5, PYRH_FUSNN
Q5L0K0, PYRH_GEOKAQ39W86, PYRH_GEOMGQ74BW2, PYRH_GEOSL
A4IMC5, PYRH_GEOTNQ7NI44, PYRH_GLOVIQ5FPZ5, PYRH_GLUOX
Q0BTM0, PYRH_GRABCQ7VL82, PYRH_HAEDUQ4QLM2, PYRH_HAEI8
A5UD40, PYRH_HAEIEA5UIJ1, PYRH_HAEIGP43890, PYRH_HAEIN
Q2SBP9, PYRH_HAHCHQ9KA65, PYRH_HALH5A1WX19, PYRH_HALHL
B9LSL4, PYRH_HALLTQ5UXX3, PYRH_HALMAB0R6V9, PYRH_HALS3
Q9HNN8, PYRH_HALSAQ18DR1, PYRH_HALWDQ17Y33, PYRH_HELAH
Q7VHX9, PYRH_HELHPQ1CT93, PYRH_HELPHQ9ZL66, PYRH_HELPJ
P56106, PYRH_HELPYA4G4S3, PYRH_HERARQ0I378, PYRH_HISS1
Q31G45, PYRH_HYDCUA2BLM0, PYRH_HYPBUQ0C1B9, PYRH_HYPNA
Q5QXS2, PYRH_IDILOA8AAG3, PYRH_IGNH4A6SZP9, PYRH_JANMA
Q28PI5, PYRH_JANSCA6T4X3, PYRH_KLEP7Q1IV36, PYRH_KORVE
Q5FJM5, PYRH_LACACQ1G9N8, PYRH_LACDAQ049U4, PYRH_LACDB
Q044C8, PYRH_LACGAA8YVR7, PYRH_LACH4Q74IR8, PYRH_LACJO
Q9CE38, PYRH_LACLAQ9Z5K8, PYRH_LACLMQ02WC4, PYRH_LACLS
Q038L4, PYRH_LACP3Q88VJ6, PYRH_LACPLQ38W66, PYRH_LATSS
Q1MRD8, PYRH_LAWIPQ5X4J9, PYRH_LEGPAA5ICK8, PYRH_LEGPC
Q5ZUT0, PYRH_LEGPHQ5WVY9, PYRH_LEGPLQ6AEV5, PYRH_LEIXX
Q04U70, PYRH_LEPBJQ053N3, PYRH_LEPBLQ72U12, PYRH_LEPIC
Q8F142, PYRH_LEPINQ03WX7, PYRH_LEUMMQ03QS3, PYRH_LEVBA
Q1WUG5, PYRH_LIGS1A5VJC7, PYRH_LIMRDQ8VS53, PYRH_LIMRT
P65928, PYRH_LISINQ720A9, PYRH_LISMFP65927, PYRH_LISMO
A0AIB4, PYRH_LISW6A0L8Q7, PYRH_MAGMMQ8EUG9, PYRH_MALP2
Q65R73, PYRH_MANSMQ0APW3, PYRH_MARMMA1U3Q2, PYRH_MARN8
Q6F0Q9, PYRH_MESFLQ600A4, PYRH_MESH2Q4A7I8, PYRH_MESH7
Q4A9E9, PYRH_MESHJA6UV05, PYRH_META3Q8TTQ4, PYRH_METAC
Q0W3K6, PYRH_METARA7I6B7, PYRH_METB6Q46EC7, PYRH_METBF
Q12VQ2, PYRH_METBUQ60BA8, PYRH_METCAQ1H141, PYRH_METFK
Q2FR36, PYRH_METHJQ58656, PYRH_METJAQ8TXB4, PYRH_METKA
A2SS66, PYRH_METLZA4FZB7, PYRH_METM5A9A6R4, PYRH_METM6
A6VJ20, PYRH_METM7P59010, PYRH_METMAA3CUB9, PYRH_METMJ
Q6M086, PYRH_METMPA2SH96, PYRH_METPPA5UK92, PYRH_METS3
A4YHL6, PYRH_METS5Q2NEL4, PYRH_METSTO26965, PYRH_METTH
A0B8B0, PYRH_METTPA6URZ7, PYRH_METVSQ2RJP1, PYRH_MOOTA
A0QJ19, PYRH_MYCA1P65930, PYRH_MYCBOA1KMM7, PYRH_MYCBP
Q2SSA5, PYRH_MYCCTQ7NC20, PYRH_MYCGAP47672, PYRH_MYCGE
O33045, PYRH_MYCLEQ6KIN6, PYRH_MYCM1Q73VR6, PYRH_MYCPA
P75165, PYRH_MYCPNQ98QZ0, PYRH_MYCPUA0QVD9, PYRH_MYCS2
Q4A587, PYRH_MYCS5A3PXZ4, PYRH_MYCSJA1UEJ0, PYRH_MYCSK
Q1BAH2, PYRH_MYCSSA5U6N8, PYRH_MYCTAP9WHK4, PYRH_MYCTO
P9WHK5, PYRH_MYCTUA1T784, PYRH_MYCVPQ1D1I1, PYRH_MYXXD
Q3IRL6, PYRH_NATPDQ5F5F5, PYRH_NEIG1P65931, PYRH_NEIMA
P65932, PYRH_NEIMBA1KWH8, PYRH_NEIMFQ2GCI6, PYRH_NEOSM
Q0AEH6, PYRH_NITECQ82TZ7, PYRH_NITEUQ1QMN5, PYRH_NITHX
Q2YBA5, PYRH_NITMUQ3JCX3, PYRH_NITOCA6Q311, PYRH_NITSB
Q72DQ8, PYRH_NITV2A1VFB1, PYRH_NITV4Q3SRH4, PYRH_NITWN
Q5YS63, PYRH_NOCFAA1SLQ8, PYRH_NOCSJQ8YXK5, PYRH_NOSS1
Q2G8K8, PYRH_NOVADQ8EQV1, PYRH_OCEIHQ04F86, PYRH_OENOB
Q313G6, PYRH_OLEA2Q6YR50, PYRH_ONYPEA5CD80, PYRH_ORITB
A1R4W1, PYRH_PAEATA1TN71, PYRH_PARC0A6LHB0, PYRH_PARD8
A1B965, PYRH_PARDPA7HY17, PYRH_PARL1Q2W4C5, PYRH_PARM1
Q7U5F5, PYRH_PARMWQ6M9Z8, PYRH_PARUWQ13XB8, PYRH_PARXL
P59005, PYRH_PARZEQ9CJL5, PYRH_PASMUQ6D8E1, PYRH_PECAS
Q03FT4, PYRH_PEDPAA1AQN4, PYRH_PELPDQ7N8P5, PYRH_PHOLL
Q6LN26, PYRH_PHOPRA6L1I4, PYRH_PHOV8Q6KZ23, PYRH_PICTO
A1VN42, PYRH_POLNAQ12A33, PYRH_POLSJQ7MTP5, PYRH_PORGI
A3PBP6, PYRH_PROM0A2C0Y1, PYRH_PROM1A8G3N7, PYRH_PROM2
A2C7Q3, PYRH_PROM3A2BVI4, PYRH_PROM5Q31C12, PYRH_PROM9
Q7VD61, PYRH_PROMAQ7V6C2, PYRH_PROMMQ7V2F8, PYRH_PROMP
A2BQ03, PYRH_PROMSQ46GQ4, PYRH_PROMTQ48F61, PYRH_PSE14
Q15WG1, PYRH_PSEA6A6V1D4, PYRH_PSEA7Q02RC6, PYRH_PSEAB
O82852, PYRH_PSEAEQ1I628, PYRH_PSEE4Q4KHH4, PYRH_PSEF5
A8F5E8, PYRH_PSELTA5W848, PYRH_PSEP1Q3KHB0, PYRH_PSEPF
Q88MH8, PYRH_PSEPKQ886P1, PYRH_PSESMQ3IIX6, PYRH_PSET1
Q4ZWS6, PYRH_PSEU2Q4FRH5, PYRH_PSYA2Q1QA12, PYRH_PSYCK
A1SYW1, PYRH_PSYINA5WGF1, PYRH_PSYWFQ9V0P2, PYRH_PYRAB
Q8ZTP3, PYRH_PYRAEA4WLE9, PYRH_PYRARA3MX54, PYRH_PYRCJ
Q8U122, PYRH_PYRFUO50116, PYRH_PYRHOA1RRX6, PYRH_PYRIL
B1Y9Y6, PYRH_PYRNVQ8XZI9, PYRH_RALN1Q2K8Y5, PYRH_RHIEC
Q1MH52, PYRH_RHIJ3Q98MB7, PYRH_RHILOQ92Q53, PYRH_RHIME
A5V3G4, PYRH_RHIWRQ7UTH1, PYRH_RHOBAQ0S283, PYRH_RHOJR
Q2IW82, PYRH_RHOP2Q07NJ1, PYRH_RHOP5Q6N5Q3, PYRH_RHOPA
Q215E7, PYRH_RHOPBQ136A6, PYRH_RHOPSQ2RU07, PYRH_RHORT
A8GMC4, PYRH_RICAHA8GV49, PYRH_RICB8Q1RHF2, PYRH_RICBR
A8EXM4, PYRH_RICCKQ92J71, PYRH_RICCNQ4UKF4, PYRH_RICFE
A8F0R3, PYRH_RICM5Q9ZE07, PYRH_RICPRA8GQY1, PYRH_RICRS
Q68XL3, PYRH_RICTYQ166F6, PYRH_ROSDOA5UUV0, PYRH_ROSS1
Q1AW66, PYRH_RUBXDQ5LSV4, PYRH_RUEPOQ1GGR9, PYRH_RUEST
A1AVT7, PYRH_RUTMCQ21HH4, PYRH_SACD2A4FMD5, PYRH_SACEN
Q97ZE2, PYRH_SACS2Q57T37, PYRH_SALCHQ5PD61, PYRH_SALPA
Q2S6J2, PYRH_SALRDP65934, PYRH_SALTIP65933, PYRH_SALTY
A8GIE4, PYRH_SERP5A1S4P2, PYRH_SHEAMA3D2K7, PYRH_SHEB5
A6WLA8, PYRH_SHEB8Q12NY5, PYRH_SHEDOQ085E0, PYRH_SHEFN
A3QGA1, PYRH_SHELPQ8EGH3, PYRH_SHEONA4Y545, PYRH_SHEPC
A0KZ21, PYRH_SHESAQ0HGV7, PYRH_SHESMQ0HT64, PYRH_SHESR
A1RLM5, PYRH_SHESWQ325W9, PYRH_SHIBSQ32JT8, PYRH_SHIDS
Q0T838, PYRH_SHIF8P0A7F2, PYRH_SHIFLQ3Z5I7, PYRH_SHISS
Q5WFT0, PYRH_SHOC1A6U8K4, PYRH_SINMWQ2NRK9, PYRH_SODGM
Q02AL3, PYRH_SOLUEQ1GRQ2, PYRH_SPHALA7X1N6, PYRH_STAA1
Q2FHI0, PYRH_STAA3Q2FZ22, PYRH_STAA8Q2YXL0, PYRH_STAAB
Q5HGH3, PYRH_STAACA6QGF8, PYRH_STAAEP65935, PYRH_STAAM
P65936, PYRH_STAANQ6GHH7, PYRH_STAARQ6G9V5, PYRH_STAAS
P65937, PYRH_STAAWQ5HPT3, PYRH_STAEQQ8CSU1, PYRH_STAES
Q4L5W0, PYRH_STAHJA3DMM2, PYRH_STAMFQ49X43, PYRH_STAS1
Q3K010, PYRH_STRA1Q8E431, PYRH_STRA3Q8DYG8, PYRH_STRA5
Q82JX9, PYRH_STRAWO69913, PYRH_STRCOA8AY71, PYRH_STRGC
Q8DSY1, PYRH_STRMUP65938, PYRH_STRP1Q04KY1, PYRH_STRP2
P0DD72, PYRH_STRP3Q5XDH4, PYRH_STRP6P65940, PYRH_STRP8
Q1JD59, PYRH_STRPBQ1JN32, PYRH_STRPCQ1JI78, PYRH_STRPD
Q1J833, PYRH_STRPFA2RG31, PYRH_STRPGQ48UX7, PYRH_STRPM
Q97R83, PYRH_STRPNP0DD73, PYRH_STRPQQ8DQ50, PYRH_STRR6
A4W2B2, PYRH_STRS2A3CPA3, PYRH_STRSVA4VW04, PYRH_STRSY
Q5M141, PYRH_STRT1Q5M5N0, PYRH_STRT2Q03M16, PYRH_STRTD
A4VJS3, PYRH_STUS1Q4J986, PYRH_SULACQ30SN5, PYRH_SULDN
C3N5A5, PYRH_SULIAC4KGX1, PYRH_SULIKC3MPM9, PYRH_SULIL
C3MYM3, PYRH_SULIMC3NHU4, PYRH_SULINC3NDV9, PYRH_SULIY
A6QB35, PYRH_SULNBQ971S6, PYRH_SULTOQ67PB5, PYRH_SYMTH
Q2LTQ5, PYRH_SYNASQ3A397, PYRH_SYNC1Q31QY1, PYRH_SYNE7
A0LJ65, PYRH_SYNFMQ2JS42, PYRH_SYNJAQ2JJE2, PYRH_SYNJB
Q5N3B6, PYRH_SYNP6A5GJF0, PYRH_SYNPWA5GSA3, PYRH_SYNR3
Q0I8L5, PYRH_SYNS3Q3AV98, PYRH_SYNS9Q3ALP7, PYRH_SYNSC
Q0AYK2, PYRH_SYNWWP74457, PYRH_SYNY3Q9HKV7, PYRH_THEAC
Q47S51, PYRH_THEFYC5A3Q1, PYRH_THEGJQ5JFZ7, PYRH_THEKO
A6LK98, PYRH_THEM4Q9X1U0, PYRH_THEMAB6YXE5, PYRH_THEON
A5ILX9, PYRH_THEP1A1RXJ4, PYRH_THEPDC6A429, PYRH_THESM
Q72KD9, PYRH_THET2P43891, PYRH_THET8Q8DM63, PYRH_THEVB
Q97B72, PYRH_THEVOQ3SKN7, PYRH_THIDAQ10Y48, PYRH_TRIEI
Q3MFI4, PYRH_TRIV2Q83HZ6, PYRH_TROW8Q83G72, PYRH_TROWT
Q9PPX6, PYRH_UREPAA1WHU4, PYRH_VEREIA5CXD7, PYRH_VESOH
A7N1X5, PYRH_VIBC1A5F619, PYRH_VIBC3Q9KPV4, PYRH_VIBCH
Q87ME0, PYRH_VIBPAQ8DBF9, PYRH_VIBVUQ7MIG2, PYRH_VIBVY
Q8D2G4, PYRH_WIGBRQ73HM2, PYRH_WOLPMQ7MAH8, PYRH_WOLSU
Q5GRI0, PYRH_WOLTRP59008, PYRH_XANACQ4USQ8, PYRH_XANC8
P59009, PYRH_XANCPQ3BVK6, PYRH_XANE5Q2P4A8, PYRH_XANOM
Q5H1E3, PYRH_XANORQ9PEH0, PYRH_XYLFAQ87EH1, PYRH_XYLFT
A1JP80, PYRH_YERE8A7FFH1, PYRH_YERP3Q1CAN2, PYRH_YERPA
Q8ZH64, PYRH_YERPEQ1CFE9, PYRH_YERPNA4TL89, PYRH_YERPP
Q667J1, PYRH_YERPSQ9X5E9, PYRH_ZYMMO

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-