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ENZYME entry: EC 2.7.7.2

Accepted Name
FAD synthase.
Alternative Name(s)
FAD diphosphorylase.
FAD pyrophosphorylase.
FADS.
Flavin adenine dinucleotide synthetase.
FMN adenylyltransferase.
Reaction catalysed
ATP + FMN <=> diphosphate + FAD
Cofactor(s)
Mg(2+).
Comment(s)
  • Highly specific for ATP as phosphate donor.
  • The cofactors FMN and FAD participate in numerous processes in all organisms, including mitochondrial electron transport, photosynthesis, fatty-acid oxidation, and metabolism of vitamin B6, vitamin B12 and folates.
  • While monofunctional FAD synthetase is found in eukaryotes and in some prokaryotes, most prokaryotes have a bifunctional enzyme that exhibits both this activity and that of EC 2.7.1.26.
Cross-references
BRENDA2.7.7.2
EC2PDB2.7.7.2
ExplorEnz2.7.7.2
PRIAM enzyme-specific profiles2.7.7.2
KEGG Ligand Database for Enzyme Nomenclature2.7.7.2
IUBMB Enzyme Nomenclature2.7.7.2
IntEnz2.7.7.2
MEDLINEFind literature relating to 2.7.7.2
MetaCyc2.7.7.2
Rhea expert-curated reactions2.7.7.2
UniProtKB/Swiss-Prot
Q626I0, FAD1_CAEBR;  Q22017, FAD1_CAEEL;  Q68EH8, FAD1_DANRE;  
Q8NFF5, FAD1_HUMAN;  Q8R123, FAD1_MOUSE;  Q5RCH4, FAD1_PONAB;  
O74841, FAD1_SCHPO;  P38913, FAD1_YEAST;  Q6ING7, FLAD1_XENLA;  
Q7NBZ0, MNMA_MYCGA;  Q8Y7F2, RIBCF_LISMO;  P54575, RIBC_BACSU;  
Q8Y914, RIBC_LISMO;  Q9FMW8, RIBF1_ARATH;  Q8VZR0, RIBF2_ARATH;  
P57250, RIBF_BUCAI;  Q8K9Z1, RIBF_BUCAP;  Q59263, RIBF_CORAM;  
P0AG42, RIBF_ECO57;  P0AG41, RIBF_ECOL6;  P0AG40, RIBF_ECOLI;  
A4IT50, RIBF_GEOTN;  P44957, RIBF_HAEIN;  P47391, RIBF_MYCGE;  
P75587, RIBF_MYCPN;  Q10BX9, RIBF_ORYSJ;  P22990, RIBF_PSEFL;  
O84990, RIBF_RHOOP;  P0AG43, RIBF_SHIFL;  P73651, RIBF_SYNY3;  
B5I9H4, RIBL_ACIB4;  O28854, RIBL_ARCFU;  D2RES5, RIBL_ARCPA;  
D3RZA9, RIBL_FERPA;  D8J4S4, RIBL_HALJB;  B9LSN4, RIBL_HALLT;  
C7P4K0, RIBL_HALMD;  B0R450, RIBL_HALS3;  Q9HRB2, RIBL_HALSA;  
D2RTP8, RIBL_HALTV;  C7NTR1, RIBL_HALUD;  D4GVJ2, RIBL_HALVD;  
B1L7J8, RIBL_KORCO;  A6UWK8, RIBL_META3;  Q8TPT5, RIBL_METAC;  
Q0W933, RIBL_METAR;  A7I4S0, RIBL_METB6;  Q46AS7, RIBL_METBF;  
Q12YR1, RIBL_METBU;  D7E8Z9, RIBL_METEZ;  C7P607, RIBL_METFA;  
E3GWN9, RIBL_METFV;  Q2FT79, RIBL_METHJ;  D5VUB0, RIBL_METIM;  
Q58579, RIBL_METJA;  Q8TXT2, RIBL_METKA;  A2SQH8, RIBL_METLZ;  
A4FXX6, RIBL_METM5;  A9AB01, RIBL_METM6;  A6VFN4, RIBL_METM7;  
Q8Q095, RIBL_METMA;  A3CXW9, RIBL_METMJ;  Q6LYP5, RIBL_METMP;  
D5EBS7, RIBL_METMS;  E1RHM5, RIBL_METP4;  B8GJN8, RIBL_METPE;  
D1YZF2, RIBL_METPS;  D3DZ18, RIBL_METRM;  A5ULI6, RIBL_METS3;  
D3S3T0, RIBL_METSF;  Q2NHB2, RIBL_METST;  O26932, RIBL_METTH;  
D9PX81, RIBL_METTM;  A0B7A6, RIBL_METTP;  D7DTT8, RIBL_METV3;  
C9RF94, RIBL_METVM;  A6UNT3, RIBL_METVS;  D3SYU6, RIBL_NATMM;  
Q3IQ95, RIBL_NATPD;  Q6L0A7, RIBL_PICTO;  Q9UZ37, RIBL_PYRAB;  
Q8U1T9, RIBL_PYRFU;  O58466, RIBL_PYRHO;  Q9HJ34, RIBL_THEAC;  
C5A1S7, RIBL_THEGJ;  Q5JHT4, RIBL_THEKO;  B6YXC8, RIBL_THEON;  
C6A439, RIBL_THESM;  Q979C2, RIBL_THEVO;  

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