ENZYME entry: EC 2.7.7.2

PURL: https://purl.expasy.org/enzyme/EC/2.7.7.2

Accepted Name

FAD synthase

Alternative Name(s)

FAD diphosphorylase

FAD pyrophosphorylase

FADS

flavin adenine dinucleotide synthetase

FMN adenylyltransferase

Reaction catalysed

FMN + ATP + H(+) = FAD + diphosphate

Comment(s)

Highly specific for ATP as phosphate donor.
The cofactors FMN and FAD participate in numerous processes in all organisms, including mitochondrial electron transport, photosynthesis, fatty-acid oxidation, and metabolism of vitamin B6, vitamin B12 and folates.
While monofunctional FAD synthetase is found in eukaryotes and in some prokaryotes, most prokaryotes have a bifunctional enzyme that exhibits both this activity and that of EC 2.7.1.26.

Cross-references

BRENDA

2.7.7.2

EC2PDB

2.7.7.2

ExplorEnz

2.7.7.2

KEGG Ligand Database for Enzyme Nomenclature

2.7.7.2

IUBMB Enzyme Nomenclature

2.7.7.2

MEDLINE

Find literature relating to 2.7.7.2

MetaCyc

2.7.7.2

Rhea expert-curated reactions

2.7.7.2

UniProtKB/Swiss-Prot

Q9LZE4, FAD1_ARATH	Q626I0, FAD1_CAEBR	Q22017, FAD1_CAEEL
Q6FNA9, FAD1_CANGA	A0A2K3D179, FAD1_CHLRE	Q68EH8, FAD1_DANRE
Q8NFF5, FAD1_HUMAN	A0A1U8CC89, FAD1_MESAU	Q8R123, FAD1_MOUSE
Q5RCH4, FAD1_PONAB	D4A4P4, FAD1_RAT	O74841, FAD1_SCHPO
P38913, FAD1_YEAST	Q6ING7, FLAD1_XENLA	Q7NBZ0, MNMA_MYCGA
Q8Y7F2, RIBCF_LISMO	P54575, RIBC_BACSU	Q8Y914, RIBC_LISMO
Q9FMW8, RIBF1_ARATH	Q8VZR0, RIBF2_ARATH	P57250, RIBF_BUCAI
Q8K9Z1, RIBF_BUCAP	Q59263, RIBF_CORAM	P0AG42, RIBF_ECO57
P0AG41, RIBF_ECOL6	P0AG40, RIBF_ECOLI	A4IT50, RIBF_GEOTN
P44957, RIBF_HAEIN	P47391, RIBF_MYCGE	P75587, RIBF_MYCPN
Q10BX9, RIBF_ORYSJ	P22990, RIBF_PSEFL	O84990, RIBF_RHOOP
P0AG43, RIBF_SHIFL	P73651, RIBF_SYNY3	B5I9H4, RIBL_ACIB4
O28854, RIBL_ARCFU	D2RES5, RIBL_ARCPA	D3RZA9, RIBL_FERPA
D8J4S4, RIBL_HALJB	B9LSN4, RIBL_HALLT	C7P4K0, RIBL_HALMD
B0R450, RIBL_HALS3	Q9HRB2, RIBL_HALSA	D2RTP8, RIBL_HALTV
C7NTR1, RIBL_HALUD	D4GVJ2, RIBL_HALVD	B1L7J8, RIBL_KORCO
A6UWK8, RIBL_META3	Q8TPT5, RIBL_METAC	Q0W933, RIBL_METAR
A7I4S0, RIBL_METB6	Q46AS7, RIBL_METBF	Q12YR1, RIBL_METBU
D7E8Z9, RIBL_METEZ	C7P607, RIBL_METFA	E3GWN9, RIBL_METFV
Q2FT79, RIBL_METHJ	D5VUB0, RIBL_METIM	Q58579, RIBL_METJA
Q8TXT2, RIBL_METKA	A2SQH8, RIBL_METLZ	A4FXX6, RIBL_METM5
A9AB01, RIBL_METM6	A6VFN4, RIBL_METM7	Q8Q095, RIBL_METMA
A3CXW9, RIBL_METMJ	Q6LYP5, RIBL_METMP	D5EBS7, RIBL_METMS
E1RHM5, RIBL_METP4	B8GJN8, RIBL_METPE	D1YZF2, RIBL_METPS
D3DZ18, RIBL_METRM	A5ULI6, RIBL_METS3	D3S3T0, RIBL_METSF
Q2NHB2, RIBL_METST	O26932, RIBL_METTH	D9PX81, RIBL_METTM
A0B7A6, RIBL_METTP	D7DTT8, RIBL_METV3	C9RF94, RIBL_METVM
A6UNT3, RIBL_METVS	D3SYU6, RIBL_NATMM	Q3IQ95, RIBL_NATPD
Q6L0A7, RIBL_PICTO	Q9UZ37, RIBL_PYRAB	Q8U1T9, RIBL_PYRFU
O58466, RIBL_PYRHO	Q9HJ34, RIBL_THEAC	C5A1S7, RIBL_THEGJ
Q5JHT4, RIBL_THEKO	B6YXC8, RIBL_THEON	C6A439, RIBL_THESM
Q979C2, RIBL_THEVO

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