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ENZYME entry: EC 2.7.7.50

Accepted Name
mRNA guanylyltransferase.
Alternative Name(s)
GTP--RNA guanylyltransferase.
mRNA capping enzyme.
Reaction catalysed
a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate
Comment(s)
The human enzyme is a multi domain protein that also has the activity of EC 3.6.1.74.
Cross-references
BRENDA2.7.7.50
EC2PDB2.7.7.50
ExplorEnz2.7.7.50
PRIAM enzyme-specific profiles2.7.7.50
KEGG Ligand Database for Enzyme Nomenclature2.7.7.50
IUBMB Enzyme Nomenclature2.7.7.50
IntEnz2.7.7.50
MEDLINEFind literature relating to 2.7.7.50
MetaCyc2.7.7.50
Rhea expert-curated reactions2.7.7.50
UniProtKB/Swiss-Prot
P41477, LEF4_NPVAC;  P11079, LMBD2_REOVD;  Q91RA4, LMBD2_REOVJ;  
Q91RA6, LMBD2_REOVL;  Q755D0, MCE1_ASHGO;  Q17607, MCE1_CAEEL;  
P78587, MCE1_CANAX;  Q6FQ31, MCE1_CANGA;  Q6NY98, MCE1_DANRE;  
Q6BT58, MCE1_DEBHA;  O60942, MCE1_HUMAN;  Q6CWR0, MCE1_KLULA;  
O55236, MCE1_MOUSE;  Q7SB53, MCE1_NEUCR;  P40997, MCE1_SCHPO;  
Q6C783, MCE1_YARLI;  Q01159, MCE1_YEAST;  Q8V2R8, MCEL_CAMPM;  
Q775U0, MCEL_CAMPS;  Q8QMV9, MCEL_CWPXB;  Q80DX6, MCEL_CWPXG;  
Q9J584, MCEL_FOWPN;  P25950, MCEL_RFVKA;  O57209, MCEL_VACCA;  
P20979, MCEL_VACCC;  Q9JFA8, MCEL_VACCT;  P04298, MCEL_VACCW;  
P0DSX5, MCEL_VAR67;  P0DSX6, MCEL_VARV;  P32094, MCE_ASFB7;  
P0C995, MCE_ASFK5;  Q65216, MCE_ASFM2;  P0C993, MCE_ASFP4;  
P0C994, MCE_ASFWA;  Q5UQX1, MCE_MIMIV;  Q84424, MCE_PBCV1;  
P14583, MCE_RDVA;  Q85437, MCE_RDVF;  Q1WNZ7, MCE_RGDV;  
P12366, MCE_WTV;  Q8VA43, VP1_AQRVA;  Q8JU62, VP1_AQRVC;  
B2BND9, VP1_AQRVG;  O56043, VP2_RRSVT;  Q9INI4, VP3_BAVJK;  
Q7TDB4, VP3_MYRV9;  Q3ZK57, VP3_ROT41;  B1NKR5, VP3_ROTAD;  
A9Q1K9, VP3_ROTB2;  A7J3A0, VP3_ROTBN;  Q65526, VP3_ROTBS;  
Q6WAT6, VP3_ROTBU;  Q6WNV6, VP3_ROTCC;  Q6WNV7, VP3_ROTEL;  
A4ZCW6, VP3_ROTH3;  Q6WNW3, VP3_ROTH6;  B1NKR1, VP3_ROTH7;  
Q82041, VP3_ROTHC;  Q6WNW5, VP3_ROTHD;  Q9QNB1, VP3_ROTHK;  
B1NKS7, VP3_ROTHL;  B1NKT1, VP3_ROTHP;  A7J392, VP3_ROTHS;  
B1NKT9, VP3_ROTHT;  Q91HJ9, VP3_ROTHU;  Q6WVH5, VP3_ROTHW;  
Q45UF7, VP3_ROTJ1;  Q6WNV8, VP3_ROTP5;  P26192, VP3_ROTPC;  
Q8BB04, VP3_ROTRF;  P15736, VP3_ROTS1;  A2T3S5, VP3_ROTSH;  
B3F2X7, VP3_ROTTU;  B2BMF9, VP3_ROTW3;  B1NKU3, VP3_ROTWI;  
A7J3A4, VP3_ROTYO;  Q91ID8, VP4_LDCPR;  Q2Y0E6, VP5_APRVF;  

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