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ENZYME

ENZYME entry: EC 3.6.1.74

PURL: https://purl.expasy.org/enzyme/EC/3.6.1.74
Accepted Name
mRNA 5'-phosphatase
Alternative Name(s)
5'-polynucleotidase
mRNA 5'-triphosphate monophosphatase
polynucleotide 5'-phosphohydrolase
Reaction catalysed
a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)
Comment(s)
  • The enzyme, found in eukaryotes and some plus strand RNA viruses (e.g. alphavirus), is involved in mRNA capping.
  • Unlike the eukaryotic enzyme, the viral enzyme requires a purine in the first position of the mRNA.
  • The human enzyme is a multi domain protein that also has the activity of EC 2.7.7.50.
Cross-references
BRENDA3.6.1.74
EC2PDB3.6.1.74
ExplorEnz3.6.1.74
KEGG Ligand Database for Enzyme Nomenclature3.6.1.74
IUBMB Enzyme Nomenclature3.6.1.74
MEDLINEFind literature relating to 3.6.1.74
MetaCyc3.6.1.74
Rhea expert-curated reactions3.6.1.74
UniProtKB/Swiss-Prot
O93803, CET1_CANALQ6FUZ2, CET1_CANGAQ5KEQ1, CET1_CRYNJ
Q6BND2, CET1_DEBHAQ755F7, CET1_EREGSQ6CT22, CET1_KLULA
Q9P6Q6, CET1_SCHPOQ6C2H4, CET1_YARLIO13297, CET1_YEAST
Q03220, CTL1_YEASTP41477, LEF4_NPVACO10340, LEF4_NPVOP
Q17607, MCE1_CAEELQ6NY98, MCE1_DANREO60942, MCE1_HUMAN
O55236, MCE1_MOUSEQ8V2R8, MCEL_CAMPMQ775U0, MCEL_CAMPS
Q8QMV9, MCEL_CWPXBQ80DX6, MCEL_CWPXGQ9J584, MCEL_FOWPN
A0A7H0DN85, MCEL_MONPVP25950, MCEL_RFVKAO57209, MCEL_VACCA
P20979, MCEL_VACCCQ9JFA8, MCEL_VACCTP04298, MCEL_VACCW
P0DSX5, MCEL_VAR67P0DSX6, MCEL_VARVP32094, MCE_ASFB7
P0C995, MCE_ASFK5Q65216, MCE_ASFM2P0C993, MCE_ASFP4
P0C994, MCE_ASFWAQ5UQX1, MCE_MIMIVQ86924, POLN_AURAV
P87515, POLN_BFVQ5XXP4, POLN_CHIK3Q8JUX6, POLN_CHIKS
Q306W6, POLN_EEEV1Q306W8, POLN_EEEV8Q4QXJ8, POLN_EEEVF
Q8V294, POLN_EEVVP36327, POLN_EEVV3Q9WJC7, POLN_EEVVM
P36328, POLN_EEVVPP27282, POLN_EEVVTQ5Y389, POLN_GETV
Q8QZ73, POLN_MAYABP13886, POLN_ONNVGO90370, POLN_ONNVI
O90368, POLN_ONNVSP13887, POLN_RRVNQ9JGL0, POLN_SAGV
Q8JJX1, POLN_SAV1Q8QL53, POLN_SAV2P08411, POLN_SFV
P27283, POLN_SINDOP03317, POLN_SINDVP13896, POLN_WEEV
Q98500, TPASE_PBCV1

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-