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ENZYME

ENZYME entry: EC 3.6.1.74

Accepted Name
mRNA 5'-phosphatase
Alternative Name(s)
5'-polynucleotidase
mRNA 5'-triphosphate monophosphatase
polynucleotide 5'-phosphohydrolase
Reaction catalysed
a 5'-end triphospho-ribonucleoside in mRNA + H2O <=> a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate
Comment(s)
  • The enzyme, found in eukaryotes and some plus strand RNA viruses (e.g. alphavirus), is involved in mRNA capping.
  • Unlike the eukaryotic enzyme, the viral enzyme requires a purine in the first position of the mRNA.
  • The human enzyme is a multi domain protein that also has the activity of EC 2.7.7.50.
Cross-references
BRENDA3.6.1.74
EC2PDB3.6.1.74
ExplorEnz3.6.1.74
PRIAM enzyme-specific profiles3.6.1.74
KEGG Ligand Database for Enzyme Nomenclature3.6.1.74
IUBMB Enzyme Nomenclature3.6.1.74
IntEnz3.6.1.74
MEDLINEFind literature relating to 3.6.1.74
MetaCyc3.6.1.74
Rhea expert-curated reactions3.6.1.74
UniProtKB/Swiss-Prot
O93803, CET1_CANALQ6FUZ2, CET1_CANGAQ5KEQ1, CET1_CRYNJ
Q6BND2, CET1_DEBHAQ755F7, CET1_EREGSQ6CT22, CET1_KLULA
Q9P6Q6, CET1_SCHPOQ6C2H4, CET1_YARLIO13297, CET1_YEAST
Q03220, CTL1_YEASTQ17607, MCE1_CAEELQ6NY98, MCE1_DANRE
O60942, MCE1_HUMANO55236, MCE1_MOUSEQ8V2R8, MCEL_CAMPM
Q775U0, MCEL_CAMPSQ8QMV9, MCEL_CWPXBQ80DX6, MCEL_CWPXG
Q9J584, MCEL_FOWPNA0A7H0DN85, MCEL_MONPVP25950, MCEL_RFVKA
O57209, MCEL_VACCAP20979, MCEL_VACCCQ9JFA8, MCEL_VACCT
P04298, MCEL_VACCWP0DSX5, MCEL_VAR67P0DSX6, MCEL_VARV
P32094, MCE_ASFB7P0C995, MCE_ASFK5Q65216, MCE_ASFM2
P0C993, MCE_ASFP4P0C994, MCE_ASFWAQ5UQX1, MCE_MIMIV
Q86924, POLN_AURAVP87515, POLN_BFVQ5XXP4, POLN_CHIK3
Q8JUX6, POLN_CHIKSQ306W6, POLN_EEEV1Q306W8, POLN_EEEV8
Q4QXJ8, POLN_EEEVFP36327, POLN_EEVV3Q8V294, POLN_EEVVC
Q9WJC7, POLN_EEVVMP36328, POLN_EEVVPP27282, POLN_EEVVT
Q5Y389, POLN_GETVQ8QZ73, POLN_MAYABP13886, POLN_ONNVG
O90370, POLN_ONNVIO90368, POLN_ONNVSP13887, POLN_RRVN
Q9JGL0, POLN_SAGVP08411, POLN_SFVP27283, POLN_SINDO
P03317, POLN_SINDVQ8QL53, POLN_SLDVQ8JJX1, POLN_SPDV
P13896, POLN_WEEV

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-