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ENZYME entry: EC 3.6.1.74

Accepted Name
mRNA 5'-phosphatase.
Alternative Name(s)
5'-polynucleotidase.
mRNA 5'-triphosphate monophosphatase.
Polynucleotide 5'-phosphohydrolase.
Reaction catalysed
A 5'-triphospho-[mRNA] + H(2)O <=> a 5'-diphospho-[mRNA] + phosphate
Comment(s)
  • The enzyme, found in eukaryotes and some plus strand RNA viruses (e.g. alphavirus), is involved in mRNA capping.
  • Unlike the eukaryotic enzyme, the viral enzyme requires a purine in the first position of the mRNA.
  • The human enzyme is a multi domain protein that also has the activity of EC 2.7.7.50.
Cross-references
BRENDA3.6.1.74
EC2PDB3.6.1.74
ExplorEnz3.6.1.74
PRIAM enzyme-specific profiles3.6.1.74
KEGG Ligand Database for Enzyme Nomenclature3.6.1.74
IUBMB Enzyme Nomenclature3.6.1.74
IntEnz3.6.1.74
MEDLINEFind literature relating to 3.6.1.74
MetaCyc3.6.1.74
Rhea expert-curated reactions3.6.1.74
UniProtKB/Swiss-Prot
Q755F7, CET1_ASHGO;  O93803, CET1_CANAL;  Q6FUZ2, CET1_CANGA;  
Q5KEQ1, CET1_CRYNJ;  Q6BND2, CET1_DEBHA;  Q6CT22, CET1_KLULA;  
Q9P6Q6, CET1_SCHPO;  Q6C2H4, CET1_YARLI;  O13297, CET1_YEAST;  
Q17607, MCE1_CAEEL;  Q6NY98, MCE1_DANRE;  O60942, MCE1_HUMAN;  
O55236, MCE1_MOUSE;  

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