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ENZYME

ENZYME entry: EC 2.7.7.61

Accepted Name
citrate lyase holo-[acyl-carrier protein] synthase
Alternative Name(s)
2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase
holo-ACP synthase
holo-citrate lyase synthase
Reaction catalysed
2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] <=> diphosphate + holo-[citrate lyase ACP]
Comment(s)
  • The gamma-subunit of EC 4.1.3.6 serves as an acyl-carrier protein (ACP) and contains the prosthetic group 2'-(5-triphosphoribosyl)- 3'-dephospho-CoA.
  • Synthesis and attachment of the prosthetic group requires the concerted action of this enzyme and EC 2.4.2.52.
  • In the enzyme from Escherichia coli, the prosthetic group is attached to serine-14 of the ACP via a phosphodiester bond.
Cross-references
BRENDA2.7.7.61
EC2PDB2.7.7.61
ExplorEnz2.7.7.61
PRIAM enzyme-specific profiles2.7.7.61
KEGG Ligand Database for Enzyme Nomenclature2.7.7.61
IUBMB Enzyme Nomenclature2.7.7.61
IntEnz2.7.7.61
MEDLINEFind literature relating to 2.7.7.61
MetaCyc2.7.7.61
Rhea expert-curated reactions2.7.7.61
UniProtKB/Swiss-Prot
P44458, CITXG_HAEINO53080, CITXG_LEUMCQ9RLT3, CITXG_WEIPA
A8AJJ1, CITX_CITK8A7ZJ00, CITX_ECO24B7UKQ6, CITX_ECO27
B7MF27, CITX_ECO45B7L8J7, CITX_ECO55P0A6G6, CITX_ECO57
B5YPW2, CITX_ECO5EB7NLX4, CITX_ECO7IB7MRQ2, CITX_ECO81
B7M4U6, CITX_ECO8AC4ZWA3, CITX_ECOBWA7ZXP1, CITX_ECOHS
A1A8P3, CITX_ECOK1Q0TK58, CITX_ECOL5Q8FK03, CITX_ECOL6
B1IYJ2, CITX_ECOLCP0A6G5, CITX_ECOLIB7N9M0, CITX_ECOLU
B6I0S3, CITX_ECOSEB1LKK6, CITX_ECOSMQ1REU8, CITX_ECOUT
B2TTH7, CITX_SHIB3Q0T702, CITX_SHIF8Q3Z4H9, CITX_SHISS
P58160, CITX_STRP1P0DA32, CITX_STRP3Q5XC31, CITX_STRP6
Q8P0Z2, CITX_STRP8A2REE2, CITX_STRPGP0DA33, CITX_STRPQ
A5F3C5, CITX_VIBC3Q9KTT8, CITX_VIBCHC3LT53, CITX_VIBCM

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