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ENZYME entry: EC 2.7.7.61

Accepted Name
Citrate lyase holo-[acyl-carrier protein] synthase.
Alternative Name(s)
2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase.
Holo-ACP synthase.
Holo-citrate lyase synthase.
Reaction catalysed
2'-(5-triphosphoribosyl)-3'-dephospho-CoA + citrate lyase apo-[acyl-carrier protein] <=> citrate lyase holo-[acyl-carrier protein] + diphosphate
Comment(s)
  • The gamma-subunit of EC 4.1.3.6 serves as an acyl-carrier protein (ACP) and contains the prosthetic group 2'-(5-triphosphoribosyl)- 3'-dephospho-CoA.
  • Synthesis and attachment of the prosthetic group requires the concerted action of this enzyme and EC 2.4.2.52.
  • In the enzyme from Escherichia coli, the prosthetic group is attached to serine-14 of the ACP via a phosphodiester bond.
Cross-references
BRENDA2.7.7.61
EC2PDB2.7.7.61
ExplorEnz2.7.7.61
PRIAM enzyme-specific profiles2.7.7.61
KEGG Ligand Database for Enzyme Nomenclature2.7.7.61
IUBMB Enzyme Nomenclature2.7.7.61
IntEnz2.7.7.61
MEDLINEFind literature relating to 2.7.7.61
MetaCyc2.7.7.61
Rhea expert-curated reactions2.7.7.61
UniProtKB/Swiss-Prot
P44458, CITXG_HAEIN;  O53080, CITXG_LEUMC;  Q9RLT3, CITXG_WEIPA;  
A8AJJ1, CITX_CITK8;  A7ZJ00, CITX_ECO24;  B7UKQ6, CITX_ECO27;  
B7MF27, CITX_ECO45;  B7L8J7, CITX_ECO55;  P0A6G6, CITX_ECO57;  
B5YPW2, CITX_ECO5E;  B7NLX4, CITX_ECO7I;  B7MRQ2, CITX_ECO81;  
B7M4U6, CITX_ECO8A;  C4ZWA3, CITX_ECOBW;  A7ZXP1, CITX_ECOHS;  
A1A8P3, CITX_ECOK1;  Q0TK58, CITX_ECOL5;  Q8FK03, CITX_ECOL6;  
B1IYJ2, CITX_ECOLC;  P0A6G5, CITX_ECOLI;  B7N9M0, CITX_ECOLU;  
B6I0S3, CITX_ECOSE;  B1LKK6, CITX_ECOSM;  Q1REU8, CITX_ECOUT;  
B2TTH7, CITX_SHIB3;  Q0T702, CITX_SHIF8;  Q3Z4H9, CITX_SHISS;  
P58160, CITX_STRP1;  P0DA32, CITX_STRP3;  Q5XC31, CITX_STRP6;  
Q8P0Z2, CITX_STRP8;  A2REE2, CITX_STRPG;  P0DA33, CITX_STRPQ;  
A5F3C5, CITX_VIBC3;  Q9KTT8, CITX_VIBCH;  C3LT53, CITX_VIBCM;  

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