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ENZYME

ENZYME entry: EC 2.4.2.52

PURL: https://purl.expasy.org/enzyme/EC/2.4.2.52
Accepted Name
triphosphoribosyl-dephospho-CoA synthase
Alternative Name(s)
2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase
Reaction catalysed
3'-dephospho-CoA + ATP = 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine
Comment(s)
  • ATP cannot be replaced by GTP, CTP, UTP, ADP or AMP.
  • The reaction involves the formation of a new alpha (1''->2') glycosidic bond between the two ribosyl moieties, with concomitant displacement of the adenine moiety of ATP.
  • The 2'-(5-triphosphoribosyl)-3'-dephospho-CoA produced can be transferred by EC 2.7.7.61 to the apo-[acyl-carrier-protein] subunit (gamma-subunit) of EC 4.1.3.6 thus converting it from an apo-enzyme into a holo-enzyme.
  • Alternatively, it can be transferred to the apo-ACP subunit of malonate decarboxylase by the action of EC 2.7.7.66.
  • Formerly EC 2.7.8.25.
Cross-references
BRENDA2.4.2.52
EC2PDB2.4.2.52
ExplorEnz2.4.2.52
KEGG Ligand Database for Enzyme Nomenclature2.4.2.52
IUBMB Enzyme Nomenclature2.4.2.52
MEDLINEFind literature relating to 2.4.2.52
MetaCyc2.4.2.52
Rhea expert-curated reactions2.4.2.52
UniProtKB/Swiss-Prot
Q57TJ8, CITG1_SALCHQ5PKJ2, CITG1_SALPAQ8Z9M0, CITG1_SALTI
Q8ZRX9, CITG1_SALTYQ57RV7, CITG2_SALCHQ5PMA7, CITG2_SALPA
Q8Z8J2, CITG2_SALTIQ8ZR14, CITG2_SALTYQ21VT1, CITG_ALBFT
A8AJJ2, CITG_CITK8A7ZIZ9, CITG_ECO24B7UKQ5, CITG_ECO27
B7MF26, CITG_ECO45B7L8J6, CITG_ECO55P58161, CITG_ECO57
B7NLX3, CITG_ECO7IB7MRQ1, CITG_ECO81B7M4U5, CITG_ECO8A
C4ZWA2, CITG_ECOBWA7ZXP0, CITG_ECOHSA1A8P2, CITG_ECOK1
Q0TK59, CITG_ECOL5Q8FK04, CITG_ECOL6B1IYJ3, CITG_ECOLC
P77231, CITG_ECOLIB7N9L9, CITG_ECOLUB6I0S2, CITG_ECOSE
B1LKK5, CITG_ECOSMQ1REU9, CITG_ECOUTB7LWM0, CITG_ESCF3
O30827, CITG_HAEDUP45414, CITG_KLEPNQ88XT4, CITG_LACPL
Q6D425, CITG_PECASC6DF89, CITG_PECCPQ6LPV0, CITG_PHOPR
A9MKG0, CITG_SALARB5RG98, CITG_SALG2B2TTH6, CITG_SHIB3
Q0T703, CITG_SHIF8Q7UDF6, CITG_SHIFLQ3Z4I0, CITG_SHISS
C0M6C1, CITG_STRE4B4U2X5, CITG_STREMQ8DUC9, CITG_STRMU
P58159, CITG_STRP1P0DA30, CITG_STRP3Q5XC41, CITG_STRP6
Q8P102, CITG_STRP8Q1JGR7, CITG_STRPDQ1J6I6, CITG_STRPF
A2REF2, CITG_STRPGQ48TH6, CITG_STRPMP0DA31, CITG_STRPQ
B5XLM1, CITG_STRPZC0MFF6, CITG_STRS7Q9KTT7, CITG_VIBCH
C3LT54, CITG_VIBCMP44458, CITXG_HAEINO53080, CITXG_LEUMC
Q9RLT3, CITXG_WEIPAQ9RGM3, MDCB_ACICAC1DNP5, MDCB_AZOVD
P71422, MDCB_KLEPNO06922, MDCB_MALRUQ48PD2, MDCB_PSE14
B7V2C0, MDCB_PSEA8Q02UM6, MDCB_PSEABQ9I6S9, MDCB_PSEAE
Q4K4F6, MDCB_PSEF5A6UY04, MDCB_PSEP7Q3K5B6, MDCB_PSEPF
Q9Z452, MDCB_PSEPUQ87V55, MDCB_PSESMQ4ZZA9, MDCB_PSEU2
A4VRZ0, MDCB_STUS1

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.2.-
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