Expasy logo

ENZYME

ENZYME entry: EC 2.7.7.65

PURL: https://purl.expasy.org/enzyme/EC/2.7.7.65
Accepted Name
diguanylate cyclase
Alternative Name(s)
DGC
Reaction catalysed
2 GTP = 3',3'-c-di-GMP + 2 diphosphate
Comment(s)
  • Can be activated by BeF3, a phosphoryl mimic, which results in dimerization.
  • Dimerization is required but is not sufficient for diguanylate- cyclase activity.
  • Cyclic di-3',5'-guanylate is an intracellular signaling molecule that controls motility and adhesion in bacterial cells; it was first identified as having a positive allosteric effect on EC 2.4.1.12.
Cross-references
BRENDA2.7.7.65
EC2PDB2.7.7.65
ExplorEnz2.7.7.65
KEGG Ligand Database for Enzyme Nomenclature2.7.7.65
IUBMB Enzyme Nomenclature2.7.7.65
MEDLINEFind literature relating to 2.7.7.65
MetaCyc2.7.7.65
Rhea expert-curated reactions2.7.7.65
UniProtKB/Swiss-Prot
P76236, CDGI_ECOLIP0DXA3, CDNB_ESCALA0A381HBN1, CDNE_CAPGB
P0DSP2, CDNE_ELIMEP0DUE2, CDNE_FLASXP0DUE3, CDNE_LACSX
A0A150XSC5, CDNG_ROSEKQ73RG3, DGCA_TREDEP0AAP2, DGCC_ECOL6
P0AAP1, DGCC_ECOLIP38097, DGCE_ECOLIQ8XAZ4, DGCF_ECO57
P76147, DGCF_ECOLIQ8X6V3, DGCI_ECO57P75801, DGCI_ECOLI
P76237, DGCJ_ECOLIQ8X8Q3, DGCM_ECO57P77302, DGCM_ECOLI
P46139, DGCN_ECOLIP76245, DGCP_ECOLIA0A0H2ZJS2, DGCP_PSEAB
Q9HT84, DGCP_PSEAEQ8XB92, DGCQ_ECO57Q8FGJ7, DGCQ_ECOL6
P76330, DGCQ_ECOLIQ1RAI4, DGCQ_ECOUTQ57N14, DGCQ_SALCH
Q5PLI4, DGCQ_SALPAQ8Z5R0, DGCQ_SALTIQ8ZNT5, DGCQ_SALTY
Q32HJ0, DGCQ_SHIDSQ83KM9, DGCQ_SHIFLQ3Z0N3, DGCQ_SHISS
Q8EGF8, DGCS_SHEONP75908, DGCT_ECOLIP31129, DGCZ_ECOLI
A0A0H3AFM6, DGC_VIBC3P0AA90, DOSC_ECO57P0AA89, DOSC_ECOLI
Q320T0, DOSC_SHIBSQ0T466, DOSC_SHIF8Q83KV7, DOSC_SHIFL
Q3Z1N3, DOSC_SHISSQ9I310, MUCR_PSEAEQ9A5I5, PLED_CAUVC
B8GZM2, PLED_CAUVNA0A0H2Z7X0, TPBB_PSEABQ9I4L5, TPBB_PSEAE
Q9KKZ4, VDCA_VIBCH

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-