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ENZYME entry: EC 2.7.7.65

Accepted Name
Diguanylate cyclase.
Alternative Name(s)
DGC.
Reaction catalysed
2 GTP <=> 2 diphosphate + cyclic di-3',5'-guanylate
Cofactor(s)
Mg(2+); Mn(2+).
Comment(s)
  • Can be activated by BeF3, a phosphoryl mimic, which results in dimerization.
  • Dimerization is required but is not sufficient for diguanylate- cyclase activity.
  • Cyclic di-3',5'-guanylate is an intracellular signaling molecule that controls motility and adhesion in bacterial cells; it was first identified as having a positive allosteric effect on EC 2.4.1.12.
Cross-references
BRENDA2.7.7.65
EC2PDB2.7.7.65
ExplorEnz2.7.7.65
PRIAM enzyme-specific profiles2.7.7.65
KEGG Ligand Database for Enzyme Nomenclature2.7.7.65
IUBMB Enzyme Nomenclature2.7.7.65
IntEnz2.7.7.65
MEDLINEFind literature relating to 2.7.7.65
MetaCyc2.7.7.65
UniProtKB/Swiss-Prot
P76236, CDGI_ECOLI;  P0DSP2, CDNE_ELIME;  P0AAP2, DGCC_ECOL6;  
P0AAP1, DGCC_ECOLI;  P38097, DGCE_ECOLI;  Q8XAZ4, DGCF_ECO57;  
P76147, DGCF_ECOLI;  Q8X6V3, DGCI_ECO57;  P75801, DGCI_ECOLI;  
P76237, DGCJ_ECOLI;  Q8X8Q3, DGCM_ECO57;  P77302, DGCM_ECOLI;  
P46139, DGCN_ECOLI;  P76245, DGCP_ECOLI;  Q8XB92, DGCQ_ECO57;  
Q8FGJ7, DGCQ_ECOL6;  P76330, DGCQ_ECOLI;  Q1RAI4, DGCQ_ECOUT;  
Q57N14, DGCQ_SALCH;  Q5PLI4, DGCQ_SALPA;  Q8Z5R0, DGCQ_SALTI;  
Q8ZNT5, DGCQ_SALTY;  Q32HJ0, DGCQ_SHIDS;  Q83KM9, DGCQ_SHIFL;  
Q3Z0N3, DGCQ_SHISS;  P75908, DGCT_ECOLI;  P31129, DGCZ_ECOLI;  
P0AA90, DOSC_ECO57;  P0AA89, DOSC_ECOLI;  Q320T0, DOSC_SHIBS;  
Q0T466, DOSC_SHIF8;  Q83KV7, DOSC_SHIFL;  Q3Z1N3, DOSC_SHISS;  
Q9A5I5, PLED_CAUVC;  B8GZM2, PLED_CAUVN;  Q9KKZ4, VDCA_VIBCH;  

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