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ENZYME

ENZYME entry: EC 2.7.7.65

Accepted Name
diguanylate cyclase
Alternative Name(s)
DGC
Reaction catalysed
2 GTP <=> 3',3'-c-di-GMP + 2 diphosphate
Comment(s)
  • Can be activated by BeF3, a phosphoryl mimic, which results in dimerization.
  • Dimerization is required but is not sufficient for diguanylate- cyclase activity.
  • Cyclic di-3',5'-guanylate is an intracellular signaling molecule that controls motility and adhesion in bacterial cells; it was first identified as having a positive allosteric effect on EC 2.4.1.12.
Cross-references
BRENDA2.7.7.65
EC2PDB2.7.7.65
ExplorEnz2.7.7.65
PRIAM enzyme-specific profiles2.7.7.65
KEGG Ligand Database for Enzyme Nomenclature2.7.7.65
IUBMB Enzyme Nomenclature2.7.7.65
IntEnz2.7.7.65
MEDLINEFind literature relating to 2.7.7.65
MetaCyc2.7.7.65
Rhea expert-curated reactions2.7.7.65
UniProtKB/Swiss-Prot
P76236, CDGI_ECOLIA0A381HBN1, CDNE_CAPGBP0DSP2, CDNE_ELIME
P0DUE2, CDNE_FLASXP0DUE3, CDNE_LACSXA0A150XSC5, CDNG_ROSEK
Q73RG3, DGCA_TREDEP0AAP2, DGCC_ECOL6P0AAP1, DGCC_ECOLI
P38097, DGCE_ECOLIQ8XAZ4, DGCF_ECO57P76147, DGCF_ECOLI
Q8X6V3, DGCI_ECO57P75801, DGCI_ECOLIP76237, DGCJ_ECOLI
Q8X8Q3, DGCM_ECO57P77302, DGCM_ECOLIP46139, DGCN_ECOLI
P76245, DGCP_ECOLIA0A0H2ZJS2, DGCP_PSEABQ9HT84, DGCP_PSEAE
Q8XB92, DGCQ_ECO57Q8FGJ7, DGCQ_ECOL6P76330, DGCQ_ECOLI
Q1RAI4, DGCQ_ECOUTQ57N14, DGCQ_SALCHQ5PLI4, DGCQ_SALPA
Q8Z5R0, DGCQ_SALTIQ8ZNT5, DGCQ_SALTYQ32HJ0, DGCQ_SHIDS
Q83KM9, DGCQ_SHIFLQ3Z0N3, DGCQ_SHISSQ8EGF8, DGCS_SHEON
P75908, DGCT_ECOLIP31129, DGCZ_ECOLIA0A0H3AFM6, DGC_VIBC3
P0AA90, DOSC_ECO57P0AA89, DOSC_ECOLIQ320T0, DOSC_SHIBS
Q0T466, DOSC_SHIF8Q83KV7, DOSC_SHIFLQ3Z1N3, DOSC_SHISS
Q9A5I5, PLED_CAUVCB8GZM2, PLED_CAUVNA0A0H2Z7X0, TPBB_PSEAB
Q9I4L5, TPBB_PSEAEQ9KKZ4, VDCA_VIBCH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.7.-
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