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ENZYME entry: EC

Accepted Name
sulfur carrier protein ThiS adenylyltransferase.
Reaction catalysed
[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) <=> [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate
  • The enzyme catalyzes the adenylation of ThiS, a sulfur carrier protein involved in the biosynthesis of thiamine.
  • The enzyme shows significant structural similarity to ubiquitin- activating enzyme.
  • In Escherichia coli, but not in Bacillus subtilis, the enzyme forms a cross link from Cys-184 to the ThiS carboxy terminus (the position that is also thiolated) via an acyldisulfide.
  • Formerly EC 2.7.7.n3.
PRIAM enzyme-specific profiles2.7.7.73
KEGG Ligand Database for Enzyme Nomenclature2.7.7.73
IUBMB Enzyme Nomenclature2.7.7.73
MEDLINEFind literature relating to
Rhea expert-curated reactions2.7.7.73
O31619, THIF_BACSU;  P30138, THIF_ECOLI;  Q72J02, TTUC_THET2;  

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