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ENZYME

ENZYME entry: EC 2.7.7.73

Accepted Name
sulfur carrier protein ThiS adenylyltransferase
Reaction catalysed
[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) <=> [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate
Comment(s)
  • The enzyme catalyzes the adenylation of ThiS, a sulfur carrier protein involved in the biosynthesis of thiamine.
  • The enzyme shows significant structural similarity to ubiquitin- activating enzyme.
  • In Escherichia coli, but not in Bacillus subtilis, the enzyme forms a cross link from Cys-184 to the ThiS carboxy terminus (the position that is also thiolated) via an acyldisulfide.
  • Formerly EC 2.7.7.n3.
Cross-references
BRENDA2.7.7.73
EC2PDB2.7.7.73
ExplorEnz2.7.7.73
PRIAM enzyme-specific profiles2.7.7.73
KEGG Ligand Database for Enzyme Nomenclature2.7.7.73
IUBMB Enzyme Nomenclature2.7.7.73
IntEnz2.7.7.73
MEDLINEFind literature relating to 2.7.7.73
MetaCyc2.7.7.73
Rhea expert-curated reactions2.7.7.73
UniProtKB/Swiss-Prot
O31619, THIF_BACSUP30138, THIF_ECOLIQ72J02, TTUC_THET2

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