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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.7.7.74

Accepted Name
1L-myo-inositol 1-phosphate cytidylyltransferase.
Alternative Name(s)
IPCT.
L-myo-inositol-1-phosphate cytidylyltransferase.
Reaction catalysed
CTP + 1L-myo-inositol 1-phosphate <=> diphosphate + CDP-1L-myo-inositol
Comment(s)
  • In many organisms this activity is catalyzed by a bifunctional enzyme.
  • The cytidylyltransferase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 (CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase) is absolutely specific for CTP and 1L-myo-inositol 1-phosphate.
  • The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments.
  • In many organisms this activity is catalyzed by a bifunctional enzyme.
  • The cytidylyltransferase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 is absolutely specific for CTP and 1L-myo- inositol 1-phosphate.
  • The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments.
Cross-references
BRENDA2.7.7.74
EC2PDB2.7.7.74
ExplorEnz2.7.7.74
PRIAM enzyme-specific profiles2.7.7.74
KEGG Ligand Database for Enzyme Nomenclature2.7.7.74
IUBMB Enzyme Nomenclature2.7.7.74
IntEnz2.7.7.74
MEDLINEFind literature relating to 2.7.7.74
MetaCyc2.7.7.74
UniProtKB/Swiss-Prot
O67379, DIPPS_AQUAE;  O29976, DIPPS_ARCFU;  Q8U1Z6, DIPPS_PYRFU;  
Q1AWQ0, DIPPS_RUBXD;  Q5JDA9, DIPPS_THEKO;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-