A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
| Accepted Name | |
|---|---|
| 3-hydroxy-4-methylanthranilate adenylyltransferase. | |
| Alternative Name(s) | |
| 4-MHA-activating enzyme. | |
| Actinomycin synthase I. | |
| Reaction catalysed | |
| ATP + 3-hydroxy-4-methylanthranilate <=> diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate | |
| Comment(s) | |
| The enzyme, characterized from the bacteria Streptomyces anulatus and Streptosporangium sibiricum, activates 3-hydroxy-4- methylanthranilate, a precursor of actinomycin antibiotics and the antitumor antibiotic sibiromycin, to an adenylate form, so it can be loaded onto a dedicated aryl-carrier protein. | |
| Cross-references | |
| BRENDA | 2.7.7.97 |
| EC2PDB | 2.7.7.97 |
| ExplorEnz | 2.7.7.97 |
| PRIAM enzyme-specific profiles | 2.7.7.97 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.7.7.97 |
| IUBMB Enzyme Nomenclature | 2.7.7.97 |
| IntEnz | 2.7.7.97 |
| MEDLINE | Find literature relating to 2.7.7.97 |
| MetaCyc | 2.7.7.97 |