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ENZYME entry: EC 2.7.7.97

Accepted Name
3-hydroxy-4-methylanthranilate adenylyltransferase.
Alternative Name(s)
4-MHA-activating enzyme.
actinomycin synthase I.
Reaction catalysed
3-hydroxy-4-methylanthranilate + ATP + H(+) <=> 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate
Comment(s)
The enzyme, characterized from the bacteria Streptomyces anulatus and Streptosporangium sibiricum, activates 3-hydroxy-4- methylanthranilate, a precursor of actinomycin antibiotics and the antitumor antibiotic sibiromycin, to an adenylate form, so it can be loaded onto a dedicated aryl-carrier protein.
Cross-references
BRENDA2.7.7.97
EC2PDB2.7.7.97
ExplorEnz2.7.7.97
PRIAM enzyme-specific profiles2.7.7.97
KEGG Ligand Database for Enzyme Nomenclature2.7.7.97
IUBMB Enzyme Nomenclature2.7.7.97
IntEnz2.7.7.97
MEDLINEFind literature relating to 2.7.7.97
MetaCyc2.7.7.97
Rhea expert-curated reactions2.7.7.97
UniProtKB/Swiss-Prot
P80435, MHAA_STRAQ;  C0LTL9, MHAA_STRSJ;  

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