ENZYME entry: EC 2.7.7.97
| Accepted Name |
|---|
| 3-hydroxy-4-methylanthranilate adenylyltransferase.
|
| Alternative Name(s) |
|---|
| 4-MHA-activating enzyme. |
| Actinomycin synthase I. |
| Reaction catalysed |
|---|
| ATP + 3-hydroxy-4-methylanthranilate <=> diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate |
| Comment(s) |
|---|
| The enzyme, characterized from the bacteria Streptomyces anulatus and
Streptosporangium sibiricum, activates 3-hydroxy-4-
methylanthranilate, a precursor of actinomycin antibiotics and the
antitumor antibiotic sibiromycin, to an adenylate form, so it can be
loaded onto a dedicated aryl-carrier protein.
|
| Cross-references |
|---|
| BRENDA | 2.7.7.97 |
| EC2PDB | 2.7.7.97 |
| ExplorEnz | 2.7.7.97 |
| PRIAM enzyme-specific profiles | 2.7.7.97 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.7.7.97 |
| IUBMB Enzyme Nomenclature | 2.7.7.97 |
| IntEnz | 2.7.7.97 |
| MEDLINE | Find literature relating to 2.7.7.97 |
| MetaCyc | 2.7.7.97 |
| Rhea expert-curated reactions | 2.7.7.97 |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.7.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-