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ENZYME

ENZYME entry: EC 2.7.8.12

PURL: https://purl.expasy.org/enzyme/EC/2.7.8.12
Accepted Name
teichoic acid poly(glycerol phosphate) polymerase
Alternative Name(s)
poly(glycerol phosphate) polymerase
Tag polymerase
teichoic acid glycerol transferase
teichoic-acid synthase
Reaction catalysed
4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol = 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)
Comment(s)
  • Involved in the biosynthesis of poly glycerol phosphate teichoic acids in bacterial cell walls.
  • This enzyme adds 30-50 glycerol units to the linker molecule, but only after it has been primed with the first glycerol unit by EC 2.7.8.44. cf. EC 2.7.8.45.
Cross-references
BRENDA2.7.8.12
EC2PDB2.7.8.12
ExplorEnz2.7.8.12
KEGG Ligand Database for Enzyme Nomenclature2.7.8.12
IUBMB Enzyme Nomenclature2.7.8.12
MEDLINEFind literature relating to 2.7.8.12
MetaCyc2.7.8.12
Rhea expert-curated reactions2.7.8.12
UniProtKB/Swiss-Prot
P13485, TAGF_BACSUQ5HLM5, TAGF_STAEQQ8RKI5, TARF_BACSH

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