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ENZYME

ENZYME entry: EC 2.7.8.28

Accepted Name
2-phospho-L-lactate transferase
Reaction catalysed
  • (2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin <=> GMP + H(+) + oxidized coenzyme F420-0
  • 7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine <=> dehydro coenzyme F420-0 + GMP + H(+)
  • 3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin <=> GMP + H(+) + oxidized 3PG-factor420-0
Comment(s)
  • This enzyme is involved in the biosynthesis of factor 420, a redox- active cofactor, in methanogenic archaea and certain bacteria.
  • The specific reaction catalyzed in vivo is determined by the availability of substrate, which in turn is determined by the enzyme present in the organism - EC 2.7.7.68, EC 2.7.7.105, or EC 2.7.7.106.
Cross-references
BRENDA2.7.8.28
EC2PDB2.7.8.28
ExplorEnz2.7.8.28
PRIAM enzyme-specific profiles2.7.8.28
KEGG Ligand Database for Enzyme Nomenclature2.7.8.28
IUBMB Enzyme Nomenclature2.7.8.28
IntEnz2.7.8.28
MEDLINEFind literature relating to 2.7.8.28
MetaCyc2.7.8.28
Rhea expert-curated reactions2.7.8.28
UniProtKB/Swiss-Prot
O29345, COFD_ARCFUQ5V5R9, COFD_HALMAB0R5L0, COFD_HALS3
Q9HPX4, COFD_HALSAQ8TST1, COFD_METACA7I4I0, COFD_METB6
Q46C16, COFD_METBFQ12W53, COFD_METBUQ2FRU9, COFD_METHJ
Q58653, COFD_METJAQ8TVA3, COFD_METKAA2SPS3, COFD_METLZ
A4FZ98, COFD_METM5A9A6P5, COFD_METM6A6VJ39, COFD_METM7
Q8PVT6, COFD_METMAQ6M067, COFD_METMPB8GF42, COFD_METPE
O27097, COFD_METTHA6US17, COFD_METVSQ3IRY6, COFD_NATPD
Q75UN1, FBIA_KITAUA0QKC7, FBIA_MYCA1Q7TWV4, FBIA_MYCBO
A1KNR3, FBIA_MYCBPC1AH35, FBIA_MYCBTQ9CCK1, FBIA_MYCLE
B2HEN2, FBIA_MYCMMQ73UJ4, FBIA_MYCPAA0QTG2, FBIA_MYCS2
A3PW85, FBIA_MYCSJA1UCJ5, FBIA_MYCSKQ1BCE8, FBIA_MYCSS
A5U7T5, FBIA_MYCTAP9WP80, FBIA_MYCTOP9WP81, FBIA_MYCTU
A0PRG8, FBIA_MYCUAQ5YQR9, FBIA_NOCFAQ82DE2, FBIA_STRAW
Q9KZK9, FBIA_STRCOB1VUV4, FBIA_STRGGQ47LX2, FBIA_THEFY

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