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ENZYME entry: EC 2.7.8.35

Accepted Name
UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucosaminephosphotransferase.
Alternative Name(s)
GlcNAc-1-phosphate transferase.
UDP-GlcNAc:undecaprenyl phosphate GlcNAc-1-phosphate transferase.
Reaction catalysed
trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP
Comment(s)
  • Isolated from Mycobacterium tuberculosis and Mycobacterium smegmatis.
  • This enzyme catalyzes the synthesis of monotrans,octacis-decaprenyl- N-acetyl-alpha-D-glucosaminyl diphosphate (mycobacterial lipid I), an essential lipid intermediate for the biosynthesis of various bacterial cell envelope components.
  • cf. EC 2.7.8.33.
Cross-references
BRENDA2.7.8.35
EC2PDB2.7.8.35
ExplorEnz2.7.8.35
PRIAM enzyme-specific profiles2.7.8.35
KEGG Ligand Database for Enzyme Nomenclature2.7.8.35
IUBMB Enzyme Nomenclature2.7.8.35
IntEnz2.7.8.35
MEDLINEFind literature relating to 2.7.8.35
MetaCyc2.7.8.35
Rhea expert-curated reactions2.7.8.35
UniProtKB/Swiss-Prot
P45830, WECA_MYCLE;  A0R211, WECA_MYCS2;  P9WMW4, WECA_MYCTO;  
P9WMW5, WECA_MYCTU;  

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