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ENZYME

ENZYME entry: EC 2.7.8.35

PURL: https://purl.expasy.org/enzyme/EC/2.7.8.35
Accepted Name
UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucosaminephosphotransferase
Alternative Name(s)
GlcNAc-1-phosphate transferase
UDP-GlcNAc:undecaprenyl phosphate GlcNAc-1-phosphate transferase
Reaction catalysed
trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP
Comment(s)
  • Isolated from Mycobacterium tuberculosis and Mycobacterium smegmatis.
  • This enzyme catalyzes the synthesis of monotrans,octacis-decaprenyl- N-acetyl-alpha-D-glucosaminyl diphosphate (mycobacterial lipid I), an essential lipid intermediate for the biosynthesis of various bacterial cell envelope components. cf. EC 2.7.8.33.
Cross-references
BRENDA2.7.8.35
EC2PDB2.7.8.35
ExplorEnz2.7.8.35
KEGG Ligand Database for Enzyme Nomenclature2.7.8.35
IUBMB Enzyme Nomenclature2.7.8.35
MEDLINEFind literature relating to 2.7.8.35
MetaCyc2.7.8.35
Rhea expert-curated reactions2.7.8.35
UniProtKB/Swiss-Prot
P45830, WECA_MYCLEA0R211, WECA_MYCS2P9WMW4, WECA_MYCTO
P9WMW5, WECA_MYCTU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.8.-
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