ENZYME entry: EC 2.8.1.12

Accepted Name

molybdopterin synthase

Alternative Name(s)

MPT synthase

Reaction catalysed

2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O = 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin

Comment(s)

Catalyzes the synthesis of molybdopterin from cyclic pyranopterin phosphate.
Two sulfur atoms are transferred to cyclic pyranopterin phosphate in order to form the characteristic ene-dithiol group found in the molybdenum cofactor.
Molybdopterin synthase consists of two large subunits forming a central dimer and two small subunits (molybdopterin-synthase sulfur- carrier proteins) that are thiocarboxylated at the C-terminus by EC 2.8.1.11, molybdopterin synthase sulfurtransferase.
The reaction occurs in prokaryotes and eukaryotes.

Cross-references

BRENDA

2.8.1.12

EC2PDB

2.8.1.12

ExplorEnz

2.8.1.12

PRIAM enzyme-specific profiles

2.8.1.12

KEGG Ligand Database for Enzyme Nomenclature

2.8.1.12

IUBMB Enzyme Nomenclature

2.8.1.12

IntEnz

2.8.1.12

MEDLINE

Find literature relating to 2.8.1.12

MetaCyc

2.8.1.12

Rhea expert-curated reactions

2.8.1.12

UniProtKB/Swiss-Prot

Q171H3, MO2B1_AEDAE	Q1DGL6, MO2B2_AEDAE	P9WJR2, MOAE1_MYCTO
P9WJR3, MOAE1_MYCTU	P9WJR0, MOAE2_MYCTO	P9WJR1, MOAE2_MYCTU
O67928, MOAE_AQUAE	O31705, MOAE_BACSU	P65396, MOAE_BRUME
P65397, MOAE_BRUSU	Q9AC50, MOAE_CAUVC	Q53091, MOAE_CERS4
P30749, MOAE_ECOLI	Q7VLN4, MOAE_HAEDU	P45308, MOAE_HAEIN
Q9K8I7, MOAE_HALH5	Q9ZL44, MOAE_HELPJ	P56422, MOAE_HELPY
Q8YWH5, MOAE_NOSS1	Q9CN24, MOAE_PASMU	Q9HX97, MOAE_PSEAE
Q9V2A7, MOAE_PYRAB	Q8XZR3, MOAE_RALN1	Q984P0, MOAE_RHILO
Q92QX5, MOAE_RHIME	P65399, MOAE_SALTI	P65398, MOAE_SALTY
Q5HDT6, MOAE_STAAC	P65400, MOAE_STAAM	P65401, MOAE_STAAN
Q6GEG3, MOAE_STAAR	Q6G751, MOAE_STAAS	Q8NVA3, MOAE_STAAW
Q9ZIM9, MOAE_STACT	Q5HLX8, MOAE_STAEQ	Q8CNE3, MOAE_STAES
Q56210, MOAE_SYNE7	Q97CL5, MOAE_THEVO	Q9KT77, MOAE_VIBCH
Q8ZGW2, MOAE_YERPE	A6R104, MOC2B_AJECN	Q7QAD7, MOC2B_ANOGA
O22827, MOC2B_ARATH	A1CJM9, MOC2B_ASPCL	B0XYQ4, MOC2B_ASPFC
Q4WWW9, MOC2B_ASPFU	A2QF55, MOC2B_ASPNC	Q2U4W2, MOC2B_ASPOR
A4FUY7, MOC2B_BOVIN	Q1DQS9, MOC2B_COCIM	B0X1V5, MOC2B_CULQU
Q86HF4, MOC2B_DICDI	B3M268, MOC2B_DROAN	B3P6R5, MOC2B_DROER
B4JHP4, MOC2B_DROGR	Q9VBX2, MOC2B_DROME	B4KBH3, MOC2B_DROMO
B4GE20, MOC2B_DROPE	Q297G3, MOC2B_DROPS	B4IJG7, MOC2B_DROSE
B4QUC0, MOC2B_DROSI	B4LVP8, MOC2B_DROVI	B4NJW0, MOC2B_DROWI
B4PUD1, MOC2B_DROYA	Q9Y8C1, MOC2B_EMENI	O96007, MOC2B_HUMAN
Q9Z223, MOC2B_MOUSE	A1D7X4, MOC2B_NEOFI	Q7SEW2, MOC2B_NEUCR
A2X0R4, MOC2B_ORYSI	Q6Z2X3, MOC2B_ORYSJ	Q0V713, MOC2B_PHANO
Q5RA61, MOC2B_PONAB	Q2KF83, MOC2B_PYRO7	B2WBW4, MOC2B_PYRTR
Q6AY59, MOC2B_RAT	A7EVF4, MOC2B_SCLS1	B5FXU9, MOC2B_TAEGU

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