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ENZYME entry: EC 2.8.1.11

Accepted Name
molybdopterin synthase sulfurtransferase
Alternative Name(s)
molybdopterin synthase sulfurylase
Reaction catalysed
[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] <=> [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]
Comment(s)
  • The enzyme transfers sulfur to form a thiocarboxylate moiety on the C-terminal glycine of the small subunit of EC 2.8.1.12.
  • In the human, the reaction is catalyzed by the rhodanese-like C-terminal domain (cf. EC 2.8.1.1) of the MOCS3 protein, a bifunctional protein that also contains EC 2.7.7.80 at the N-terminal domain.
  • Formerly EC 2.8.1.n1.
Cross-references
BRENDA2.8.1.11
EC2PDB2.8.1.11
ExplorEnz2.8.1.11
PRIAM enzyme-specific profiles2.8.1.11
KEGG Ligand Database for Enzyme Nomenclature2.8.1.11
IUBMB Enzyme Nomenclature2.8.1.11
IntEnz2.8.1.11
MEDLINEFind literature relating to 2.8.1.11
MetaCyc2.8.1.11
Rhea expert-curated reactions2.8.1.11
UniProtKB/Swiss-Prot
B5DS72, MOC31_DROPSB6TNK6, MOC31_MAIZEQ29PG5, MOC32_DROPS
B4FAT0, MOC32_MAIZEQ17CA7, MOCS3_AEDAEQ7PY41, MOCS3_ANOGA
Q9ZNW0, MOCS3_ARATHA1A4L8, MOCS3_BOVINA8WRE3, MOCS3_CAEBR
O44510, MOCS3_CAEELB0W377, MOCS3_CULQUQ8AWD2, MOCS3_DANRE
B3MLX7, MOCS3_DROANB4JBC4, MOCS3_DROGRQ9VLJ8, MOCS3_DROME
B4KI53, MOCS3_DROMOB4GKQ3, MOCS3_DROPEB4HYP0, MOCS3_DROSE
B4LRB9, MOCS3_DROVIB4N7R4, MOCS3_DROWIB4NXF7, MOCS3_DROYA
O95396, MOCS3_HUMANA2BDX3, MOCS3_MOUSEA3ACF3, MOCS3_ORYSJ
A5GFZ6, MOCS3_PIGQ58E95, MOCS3_XENLAA1CAZ7, UBA4_ASPCL
B0Y0P7, UBA4_ASPFCQ4WV19, UBA4_ASPFUA2R3H4, UBA4_ASPNC
Q2TWN3, UBA4_ASPORQ0CFD4, UBA4_ASPTNQ55FS0, UBA4_DICDI
O59954, UBA4_EMENIA1DED8, UBA4_NEOFIA4RPM5, UBA4_PYRO7
A7F582, UBA4_SCLS1

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.-.-
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