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ENZYME

ENZYME entry: EC 2.8.1.9

Accepted Name
molybdenum cofactor sulfurtransferase
Alternative Name(s)
MoCo sulfurase
MoCo sulfurtransferase
molybdenum cofactor sulfurase
Reaction catalysed
Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Comment(s)
  • Replaces the equatorial oxo ligand of the molybdenum by sulfur via an enzyme-bound persulfide.
  • The reaction occurs in prokaryotes and eukaryotes but MoCo sulfurtransferases are only found in eukaryotes.
  • In prokaryotes the reaction is catalyzed by two enzymes: EC 2.8.1.7, which is homologous to the N-terminus of eukaryotic MoCo sulfurtransferases, and a molybdo-enzyme specific chaperone which binds the MoCo and acts as an adapter protein.
Cross-references
BRENDA2.8.1.9
EC2PDB2.8.1.9
ExplorEnz2.8.1.9
KEGG Ligand Database for Enzyme Nomenclature2.8.1.9
IUBMB Enzyme Nomenclature2.8.1.9
MEDLINEFind literature relating to 2.8.1.9
MetaCyc2.8.1.9
Rhea expert-curated reactions2.8.1.9
UniProtKB/Swiss-Prot
Q16GH0, MOCO1_AEDAEB0WSW8, MOCO1_CULQUQ16P87, MOCO2_AEDAE
B0WSX1, MOCO2_CULQUQ16P90, MOCO3_AEDAEQ7QFL7, MOCOS_ANOGA
Q9C5X8, MOCOS_ARATHA1CHL0, MOCOS_ASPCLB0Y691, MOCOS_ASPFC
Q4WPE6, MOCOS_ASPFUA2QIK9, MOCOS_ASPNCQ2UH11, MOCOS_ASPOR
Q0CLW8, MOCOS_ASPTNQ8IU29, MOCOS_BOMMOA6SRX6, MOCOS_BOTFB
Q9N0E7, MOCOS_BOVINA8X493, MOCOS_CAEBRQ21657, MOCOS_CAEEL
Q2HE65, MOCOS_CHAGBA2VD33, MOCOS_DANREQ559G8, MOCOS_DICDI
B3MZN7, MOCOS_DROANB3NY19, MOCOS_DROERB4JXP7, MOCOS_DROGR
Q9VRA2, MOCOS_DROMEB4L340, MOCOS_DROMOB4H0S8, MOCOS_DROPE
Q29GM0, MOCOS_DROPSB4N1V2, MOCOS_DROWIB4PYH5, MOCOS_DROYA
Q9UV64, MOCOS_EMENIQ96EN8, MOCOS_HUMANQ14CH1, MOCOS_MOUSE
A1CX75, MOCOS_NEOFIQ7SE17, MOCOS_NEUCRQ655R6, MOCOS_ORYSJ
A4RK48, MOCOS_PYRO7Q8LGM7, MOCOS_SOLLC

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.-.-
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