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ENZYME

ENZYME entry: EC 2.8.2.14

PURL: https://purl.expasy.org/enzyme/EC/2.8.2.14
Accepted Name
bile-salt sulfotransferase
Alternative Name(s)
BAST I
bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase
bile acid sulfotransferase I
bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase
glycolithocholate sulfotransferase
Reaction catalysed
  • glycolithocholate + 3'-phosphoadenylyl sulfate = glycolithocholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)
  • taurolithocholate + 3'-phosphoadenylyl sulfate = taurolithocholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)
Comment(s)
  • The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species.
  • This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase.
  • In addition to the 5beta-bile acid glycolithocholate, deoxycholate, 3beta-hydroxy-5-cholenoate and dehydroepiandrosterone (3beta- hydroxyandrost-5-en-17-one) also act as substrates (see also EC 2.8.2.2 and EC 2.8.2.34).
  • May be identical to EC 2.8.2.2.
Cross-references
BRENDA2.8.2.14
EC2PDB2.8.2.14
ExplorEnz2.8.2.14
KEGG Ligand Database for Enzyme Nomenclature2.8.2.14
IUBMB Enzyme Nomenclature2.8.2.14
MEDLINEFind literature relating to 2.8.2.14
MetaCyc2.8.2.14
Rhea expert-curated reactions2.8.2.14
UniProtKB/Swiss-Prot
Q06520, ST2A1_HUMANP52842, ST2A1_MACFAP52843, ST2A1_MOUSE
P15709, ST2A1_RATB2RVI8, ST2A6_MOUSEP22789, ST2A6_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.-.-
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