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ENZYME entry: EC 2.8.2.14

Accepted Name
bile-salt sulfotransferase.
Alternative Name(s)
BAST I.
bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase.
bile acid sulfotransferase I.
bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase.
glycolithocholate sulfotransferase.
Reaction catalysed
  • 3'-phosphoadenylyl sulfate + glycolithocholate <=> adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate
  • 3'-phosphoadenylyl sulfate + taurolithocholate <=> adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate
Comment(s)
  • The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species.
  • This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase.
  • In addition to the 5beta-bile acid glycolithocholate, deoxycholate, 3beta-hydroxy-5-cholenoate and dehydroepiandrosterone (3beta- hydroxyandrost-5-en-17-one) also act as substrates (see also EC 2.8.2.2 and EC 2.8.2.34).
  • May be identical to EC 2.8.2.2.
Cross-references
BRENDA2.8.2.14
EC2PDB2.8.2.14
ExplorEnz2.8.2.14
PRIAM enzyme-specific profiles2.8.2.14
KEGG Ligand Database for Enzyme Nomenclature2.8.2.14
IUBMB Enzyme Nomenclature2.8.2.14
IntEnz2.8.2.14
MEDLINEFind literature relating to 2.8.2.14
MetaCyc2.8.2.14
Rhea expert-curated reactions2.8.2.14
UniProtKB/Swiss-Prot
Q06520, ST2A1_HUMAN;  P52842, ST2A1_MACFA;  P52843, ST2A1_MOUSE;  
P15709, ST2A1_RAT;  P50236, ST2A2_MOUSE;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.-.-
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