ENZYME entry: EC 2.8.2.14
Accepted Name |
bile-salt sulfotransferase.
|
Alternative Name(s) |
BAST I. |
bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase. |
bile acid sulfotransferase I. |
bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase. |
glycolithocholate sulfotransferase. |
Reaction catalysed |
- 3'-phosphoadenylyl sulfate + glycolithocholate <=> adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate
- 3'-phosphoadenylyl sulfate + taurolithocholate <=> adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate
|
Comment(s) |
- The formation of sulfate esters of bile acids is an essential step in
the prevention of toxicity by monohydroxy bile acids in many species.
- This enzyme is both a bile salt and a 3-hydroxysteroid
sulfotransferase.
- In addition to the 5beta-bile acid glycolithocholate, deoxycholate,
3beta-hydroxy-5-cholenoate and dehydroepiandrosterone (3beta-
hydroxyandrost-5-en-17-one) also act as substrates (see also
EC 2.8.2.2 and EC 2.8.2.34).
- May be identical to EC 2.8.2.2.
|
Cross-references |
BRENDA | 2.8.2.14 |
EC2PDB | 2.8.2.14 |
ExplorEnz | 2.8.2.14 |
PRIAM enzyme-specific profiles | 2.8.2.14 |
KEGG Ligand Database for Enzyme Nomenclature | 2.8.2.14 |
IUBMB Enzyme Nomenclature | 2.8.2.14 |
IntEnz | 2.8.2.14 |
MEDLINE | Find literature relating to 2.8.2.14 |
MetaCyc | 2.8.2.14 |
Rhea expert-curated reactions | 2.8.2.14 |
UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.8.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.-.-
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