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ENZYME entry: EC 2.8.3.28

Accepted Name
phenylsuccinyl-CoA transferase
Reaction catalysed
  • phenylsuccinate + succinyl-CoA <=> 2-phenylsuccinyl-CoA + succinate
  • phenylsuccinate + succinyl-CoA <=> 3-phenylsuccinyl-CoA + succinate
Comment(s)
  • The enzyme, characterized from the bacterium Aromatoleum aromaticum, is involved in degradation of (indol-3-yl)acetate, where it is believed to function on (2-aminophenyl)succinate.
  • It has a broad substrate specificity toward other C-4 dicarboxylic acids, phenylacetate, and the non-physiological compound 2-naphthylacetate.
  • The enzyme produces 2- and 3-phenylsuccinyl-CoA in equimolar amounts.
  • It can also perform an intramolecular transfer of the CoA moiety to convert 2-phenylsuccinyl-CoA to 3-phenylsuccinyl-CoA.
Cross-references
BRENDA2.8.3.28
EC2PDB2.8.3.28
ExplorEnz2.8.3.28
PRIAM enzyme-specific profiles2.8.3.28
KEGG Ligand Database for Enzyme Nomenclature2.8.3.28
IUBMB Enzyme Nomenclature2.8.3.28
IntEnz2.8.3.28
MEDLINEFind literature relating to 2.8.3.28
MetaCyc2.8.3.28
Rhea expert-curated reactions2.8.3.28
UniProtKB/Swiss-Prot
Q5P5Z3, IAAL_AROAE

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