A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_09. Read more about EC 7 here.
ENZYME entry: EC 2.8.4.1
| Accepted Name |
|---|
| Coenzyme-B sulfoethylthiotransferase.
|
| Alternative Name(s) |
|---|
| Methyl coenzyme M reductase. |
| Methyl-CoM reductase. |
| Reaction catalysed |
|---|
| Methyl-CoM + CoB <=> CoM-S-S-CoB + methane |
| Cofactor(s) |
|---|
| Coenzyme F430.
|
| Comment(s) |
|---|
- This enzyme catalyzes the final step in methanogenesis,
the biological production of methane.
- This important anaerobic process is carried out only by methanogenic
archaea.
- The enzyme can also function in reverse, for anaerobic oxidation of
methane.
- The enzyme requires the hydroporphinoid nickel complex coenzyme
F(430).
- Highly specific for coenzyme B with a heptanoyl chain; ethyl CoM and
difluoromethyl CoM are poor substrates.
- The sulfide sulfur can be replaced by selenium but not by oxygen.
|
| Cross-references |
|---|
| BRENDA | 2.8.4.1 |
| EC2PDB | 2.8.4.1 |
| ExplorEnz | 2.8.4.1 |
| PRIAM enzyme-specific profiles | 2.8.4.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.8.4.1 |
| IUBMB Enzyme Nomenclature | 2.8.4.1 |
| IntEnz | 2.8.4.1 |
| MEDLINE | Find literature relating to 2.8.4.1 |
| MetaCyc | 2.8.4.1 |
| UniProtKB/Swiss-Prot |
| P07962, MCRA_METBF; | P12971, MCRA_METFE; | Q58256, MCRA_METJA; |
| Q49605, MCRA_METKA; | P22948, MCRA_METTE; | O27232, MCRA_METTH; |
| P11558, MCRA_METTM; | P07961, MCRA_METVA; | P11559, MCRA_METVO; |
| P07955, MCRB_METBF; | P12972, MCRB_METFE; | Q58252, MCRB_METJA; |
| P22949, MCRB_METTE; | O27236, MCRB_METTH; | P11560, MCRB_METTM; |
| P07956, MCRB_METVA; | P11561, MCRB_METVO; | P07964, MCRG_METBF; |
| P12973, MCRG_METFE; | Q58255, MCRG_METJA; | P22950, MCRG_METTE; |
| O27233, MCRG_METTH; | P11562, MCRG_METTM; | P07963, MCRG_METVA; |
| P11563, MCRG_METVO; | Q49174, MCRX_METFV; | Q60391, MCRX_METJA; |
| P21110, MCRX_METTH; | P58815, MCRX_METTM; | Q49171, MCRY_METFV; |
| Q60390, MCRY_METJA; | P21111, MCRY_METTH; | Q49173, MCRZ_METFV; |
| Q60387, MCRZ_METJA; | P21112, MCRZ_METTH; | P58816, MCRZ_METTM; |
|
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