ENZYME entry: EC 2.9.1.2
| Accepted Name |
|---|
| O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase.
|
| Alternative Name(s) |
|---|
| O-phosphoseryl-tRNA(Sec) selenium transferase. |
| O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase. |
| SepSecS. |
| Reaction catalysed |
|---|
| O-phospho-L-seryl-tRNA(Sec) + selenophosphate + H(2)O <=> L-selenocysteinyl-tRNA(Sec) + 2 phosphate |
| Cofactor(s) |
|---|
| Pyridoxal 5'-phosphate.
|
| Comment(s) |
|---|
- In archaea and eukarya selenocysteine formation is achieved by a two-
step process: EC 2.7.1.164 phosphorylates the endogenous L-seryl-
tRNA(Sec) to O-phospho-L-seryl-tRNA(Sec), and then this misacylated
amino acid-tRNA species is converted to L-selenocysteinyl-tRNA(Sec)
by Sep-tRNA:Sec-tRNA synthase.
- Formerly EC 2.9.1.n1.
|
| Cross-references |
|---|
| BRENDA | 2.9.1.2 |
| EC2PDB | 2.9.1.2 |
| ExplorEnz | 2.9.1.2 |
| PRIAM enzyme-specific profiles | 2.9.1.2 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.9.1.2 |
| IUBMB Enzyme Nomenclature | 2.9.1.2 |
| IntEnz | 2.9.1.2 |
| MEDLINE | Find literature relating to 2.9.1.2 |
| MetaCyc | 2.9.1.2 |
| UniProtKB/Swiss-Prot |
| Q61JN8, SPCS_CAEBR; | Q18953, SPCS_CAEEL; | Q803A7, SPCS_DANRE; |
| Q54VQ6, SPCS_DICDI; | Q9HD40, SPCS_HUMAN; | Q58027, SPCS_METJA; |
| Q8TXK0, SPCS_METKA; | Q6LZM9, SPCS_METMP; | Q6P6M7, SPCS_MOUSE; |
| Q5RAK7, SPCS_PONAB; | Q28EN2, SPCS_XENTR; |
|
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