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ENZYME entry: EC 2.9.1.2

Accepted Name
O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase.
Alternative Name(s)
O-phosphoseryl-tRNA(Sec) selenium transferase.
O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase.
SepSecS.
Reaction catalysed
O-phospho-L-seryl-tRNA(Sec) + selenophosphate + H(2)O <=> L-selenocysteinyl-tRNA(Sec) + 2 phosphate
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • In archaea and eukarya selenocysteine formation is achieved by a two- step process: EC 2.7.1.164 phosphorylates the endogenous L-seryl- tRNA(Sec) to O-phospho-L-seryl-tRNA(Sec), and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNA(Sec) by Sep-tRNA:Sec-tRNA synthase.
  • Formerly EC 2.9.1.n1.
Cross-references
BRENDA2.9.1.2
EC2PDB2.9.1.2
ExplorEnz2.9.1.2
PRIAM enzyme-specific profiles2.9.1.2
KEGG Ligand Database for Enzyme Nomenclature2.9.1.2
IUBMB Enzyme Nomenclature2.9.1.2
IntEnz2.9.1.2
MEDLINEFind literature relating to 2.9.1.2
MetaCyc2.9.1.2
Rhea expert-curated reactions2.9.1.2
UniProtKB/Swiss-Prot
Q61JN8, SPCS_CAEBR;  Q18953, SPCS_CAEEL;  Q803A7, SPCS_DANRE;  
Q54VQ6, SPCS_DICDI;  Q9HD40, SPCS_HUMAN;  A0A3S7WQS5, SPCS_LEIDO;  
Q58027, SPCS_METJA;  Q8TXK0, SPCS_METKA;  Q6LZM9, SPCS_METMP;  
Q6P6M7, SPCS_MOUSE;  Q5RAK7, SPCS_PONAB;  Q28EN2, SPCS_XENTR;  

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