ENZYME entry: EC 2.9.1.2
Accepted Name |
O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase.
|
Alternative Name(s) |
O-phosphoseryl-tRNA(Sec) selenium transferase. |
O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase. |
SepSecS. |
Reaction catalysed |
O-phospho-L-seryl-tRNA(Sec) + selenophosphate + H(2)O <=> L-selenocysteinyl-tRNA(Sec) + 2 phosphate |
Cofactor(s) |
Pyridoxal 5'-phosphate.
|
Comment(s) |
- In archaea and eukarya selenocysteine formation is achieved by a two-
step process: EC 2.7.1.164 phosphorylates the endogenous L-seryl-
tRNA(Sec) to O-phospho-L-seryl-tRNA(Sec), and then this misacylated
amino acid-tRNA species is converted to L-selenocysteinyl-tRNA(Sec)
by Sep-tRNA:Sec-tRNA synthase.
- Formerly EC 2.9.1.n1.
|
Cross-references |
BRENDA | 2.9.1.2 |
EC2PDB | 2.9.1.2 |
ExplorEnz | 2.9.1.2 |
PRIAM enzyme-specific profiles | 2.9.1.2 |
KEGG Ligand Database for Enzyme Nomenclature | 2.9.1.2 |
IUBMB Enzyme Nomenclature | 2.9.1.2 |
IntEnz | 2.9.1.2 |
MEDLINE | Find literature relating to 2.9.1.2 |
MetaCyc | 2.9.1.2 |
UniProtKB/Swiss-Prot |
Q61JN8, SPCS_CAEBR; | Q18953, SPCS_CAEEL; | Q803A7, SPCS_DANRE; |
Q54VQ6, SPCS_DICDI; | Q9HD40, SPCS_HUMAN; | A0A3S7WQS5, SPCS_LEIDO; |
Q58027, SPCS_METJA; | Q8TXK0, SPCS_METKA; | Q6LZM9, SPCS_METMP; |
Q6P6M7, SPCS_MOUSE; | Q5RAK7, SPCS_PONAB; | Q28EN2, SPCS_XENTR; |
|
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