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ENZYME

ENZYME entry: EC 2.9.1.2

PURL: https://purl.expasy.org/enzyme/EC/2.9.1.2
Accepted Name
O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase
Alternative Name(s)
O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase
O-phosphoseryl-tRNA(Sec) selenium transferase
SepSecS
Reaction catalysed
O-phospho-L-seryl-tRNA(Sec) + selenophosphate + H2O = L-selenocysteinyl-tRNA(Sec) + 2 phosphate
Comment(s)
  • In archaea and eukarya selenocysteine formation is achieved by a two- step process: EC 2.7.1.164 phosphorylates the endogenous L-seryl- tRNA(Sec) to O-phospho-L-seryl-tRNA(Sec), and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNA(Sec) by Sep-tRNA:Sec-tRNA synthase.
  • Formerly EC 2.9.1.n1.
Cross-references
BRENDA2.9.1.2
EC2PDB2.9.1.2
ExplorEnz2.9.1.2
KEGG Ligand Database for Enzyme Nomenclature2.9.1.2
IUBMB Enzyme Nomenclature2.9.1.2
MEDLINEFind literature relating to 2.9.1.2
MetaCyc2.9.1.2
Rhea expert-curated reactions2.9.1.2
UniProtKB/Swiss-Prot
Q61JN8, SPCS_CAEBRQ18953, SPCS_CAEELQ803A7, SPCS_DANRE
Q54VQ6, SPCS_DICDIQ9HD40, SPCS_HUMANA0A3S7WQS5, SPCS_LEIDO
Q58027, SPCS_METJAQ8TXK0, SPCS_METKAQ6LZM9, SPCS_METMP
Q6P6M7, SPCS_MOUSEQ5RAK7, SPCS_PONABQ28EN2, SPCS_XENTR

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.9.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.9.-.-
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