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ENZYME

ENZYME entry: EC 3.1.1.106

Accepted Name
O-acetyl-ADP-ribose deacetylase
Reaction catalysed
  • 3''-O-acetyl-ADP-D-ribose + H2O <=> acetate + ADP-D-ribose + H(+)
  • 2''-O-acetyl-ADP-D-ribose + H2O <=> acetate + ADP-D-ribose + H(+)
Comment(s)
  • The enzyme, characterized from the bacterium Escherichia coli and from human cells, removes the acetyl group from either the 2'' or 3'' position of O-acetyl-ADP-ribose, which are formed by the action of EC 2.3.1.286.
  • The human enzyme can also remove ADP-D-ribose from phosphorylated double stranded DNA adducts.
Cross-references
BRENDA3.1.1.106
EC2PDB3.1.1.106
ExplorEnz3.1.1.106
PRIAM enzyme-specific profiles3.1.1.106
KEGG Ligand Database for Enzyme Nomenclature3.1.1.106
IUBMB Enzyme Nomenclature3.1.1.106
IntEnz3.1.1.106
MEDLINEFind literature relating to 3.1.1.106
MetaCyc3.1.1.106
Rhea expert-curated reactions3.1.1.106
UniProtKB/Swiss-Prot
Q2KHU5, MACD1_BOVINQ9BQ69, MACD1_HUMANQ922B1, MACD1_MOUSE
Q8K4G6, MACD1_RATE1SDF1, YMDB1_PANVCE1PL40, YMDB2_PANVC
A8AI35, YMDB_CITK8D2TT52, YMDB_CITRIA7MG20, YMDB_CROS8
C9Y0V8, YMDB_CROTZP0A8D8, YMDB_ECO57P0A8D7, YMDB_ECOL6
P0A8D6, YMDB_ECOLIA4W960, YMDB_ENT38D5CE05, YMDB_ENTCC
B7LT90, YMDB_ESCF3B5XXK9, YMDB_KLEP3D3RKJ0, YMDB_KLEVT
B5F961, YMDB_SALA4B5RBF3, YMDB_SALG2B4T2X8, YMDB_SALNS
P67342, YMDB_SALTIP67341, YMDB_SALTYQ32E73, YMDB_SHIDS
Q0T5Z6, YMDB_SHIF8

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
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