Expasy logo

ENZYME

ENZYME entry: EC 3.1.1.116

PURL: https://purl.expasy.org/enzyme/EC/3.1.1.116
Accepted Name
sn-1-specific diacylglycerol lipase
Reaction catalysed
a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)
Comment(s)
  • The enzyme, present in animals, is specific for the sn-1 position.
  • When acting on 1-acyl-2-arachidonoyl-sn-glycerol, the enzyme forms 2-arachidonoylglycerol, the most abundant endocannabinoid in the mammalian brain.
Cross-references
BRENDA3.1.1.116
EC2PDB3.1.1.116
ExplorEnz3.1.1.116
KEGG Ligand Database for Enzyme Nomenclature3.1.1.116
IUBMB Enzyme Nomenclature3.1.1.116
MEDLINEFind literature relating to 3.1.1.116
MetaCyc3.1.1.116
Rhea expert-curated reactions3.1.1.116
UniProtKB/Swiss-Prot
Q3SZ73, ABHDB_BOVINQ6DRD9, ABHDB_DANREQ8NFV4, ABHDB_HUMAN
Q8K4F5, ABHDB_MOUSEQ2TAP9, ABHDB_XENLAQ0V9K2, ABHDB_XENTR
Q9Y4D2, DGLA_HUMANQ6WQJ1, DGLA_MOUSEQ5YLM1, DGLA_RAT
Q8NCG7, DGLB_HUMANQ91WC9, DGLB_MOUSEP0C1S9, DGLB_RAT

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-