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ENZYME entry: EC 3.1.1.118

Accepted Name
phospholipid sn-1 acylhydrolase.
Alternative Name(s)
PA-PLA1.
phosphatidic acid-preferring phospholipase A1.
phospholipase DDHD1.
Reaction catalysed
  • a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)
  • a 1,2-diacyl-sn-glycero-3-phosphate + H2O <=> a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+)
Comment(s)
  • The human enzyme shows broad specificity, and has a preference for phosphatidate over other phospholipids.
  • Unlike EC 3.1.1.32 it is also active against phosphatidylinositol.
  • It is not active toward acyl groups linked at the sn-2 position.
Cross-references
BRENDA3.1.1.118
EC2PDB3.1.1.118
ExplorEnz3.1.1.118
PRIAM enzyme-specific profiles3.1.1.118
KEGG Ligand Database for Enzyme Nomenclature3.1.1.118
IUBMB Enzyme Nomenclature3.1.1.118
IntEnz3.1.1.118
MEDLINEFind literature relating to 3.1.1.118
MetaCyc3.1.1.118
Rhea expert-curated reactions3.1.1.118

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-