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ENZYME

ENZYME entry: EC 3.1.1.3

Accepted Name
triacylglycerol lipase
Alternative Name(s)
lipase
tributyrase
triglyceride lipase
Reaction catalysed
a triacylglycerol + H2O <=> a diacylglycerol + a fatty acid + H(+)
Comment(s)
  • The enzyme is found in diverse organisms including animals, plants, fungi, and bacteria.
  • It hydrolyzes triglycerides into diglycerides and subsequently into monoglycerides and free fatty acids.
  • The enzyme is highly soluble in water and acts at the surface of oil droplets.
  • Access to the active site is controlled by the opening of a lid, which, when closed, hides the hydrophobic surface that surrounds the active site.
  • The lid opens when the enzyme contacts an oil-water interface (interfacial activation).
  • The pancreatic enzyme requires a protein cofactor, namely colipase, to counteract the inhibitory effects of bile salts.
Cross-references
BRENDA3.1.1.3
EC2PDB3.1.1.3
ExplorEnz3.1.1.3
PRIAM enzyme-specific profiles3.1.1.3
KEGG Ligand Database for Enzyme Nomenclature3.1.1.3
IUBMB Enzyme Nomenclature3.1.1.3
IntEnz3.1.1.3
MEDLINEFind literature relating to 3.1.1.3
MetaCyc3.1.1.3
Rhea expert-curated reactions3.1.1.3
UniProtKB/Swiss-Prot
Q0P5B7, AAAD_BOVINP22760, AAAD_HUMANQ99PG0, AAAD_MOUSE
Q7M370, AAAD_RABITQ9QZH8, AAAD_RATQ0V1P1, AT151_PHANO
A6REI4, ATG15_AJECNQ75EN3, ATG15_ASHGOA1C6D6, ATG15_ASPCL
Q4X180, ATG15_ASPFUA2QGD9, ATG15_ASPNCQ0CXU6, ATG15_ASPTN
Q5A4N0, ATG15_CANALQ6FPI6, ATG15_CANGAQ2H6M8, ATG15_CHAGB
Q1DZE0, ATG15_COCIMP0CO61, ATG15_CRYNBP0CO60, ATG15_CRYNJ
Q6BLM0, ATG15_DEBHAQ5B0L1, ATG15_EMENII1RFN8, ATG15_GIBZE
Q6CU02, ATG15_KLULAA5E567, ATG15_LODELA1DH10, ATG15_NEOFI
Q7RYY1, ATG15_NEUCRO13444, ATG15_PASFUA7KAM5, ATG15_PENRW
A7KAJ9, ATG15_PICANA5DC90, ATG15_PICGUA3LV34, ATG15_PICST
O13934, ATG15_SCHPOQ4PHZ2, ATG15_USTMAA7TG13, ATG15_VANPO
Q6C2N7, ATG15_YARLIA6ZTP2, ATG15_YEAS7P25641, ATG15_YEAST
Q09851, AYR1_SCHPOP40471, AYR1_YEASTP30122, CEL_BOVIN
P19835, CEL_HUMANQ64285, CEL_MOUSEP07882, CEL_RAT
Q8NCG7, DGLB_HUMANQ91WC9, DGLB_MOUSEP0C1S9, DGLB_RAT
P37957, ESTA_BACSUQ79F14, ESTB_BACSUP38139, LDH1_YEAST
P47145, LIH1_YEASTQ9P4E5, LIP10_CANALQ71DJ5, LIP1_ARATH
D4ASH1, LIP1_ARTBCO94091, LIP1_CANAXP79066, LIP1_DIPFE
P20261, LIP1_DIURUP17573, LIP1_GEOCNP19833, LIP1_MORS1
P40601, LIP1_PHOLUQ02104, LIP1_PSYIMQ2FUU5, LIP1_STAA8
Q5HCM7, LIP1_STAACP65288, LIP1_STAAMP65289, LIP1_STAAN
Q6GDD3, LIP1_STAARQ6G604, LIP1_STAASQ8NUI5, LIP1_STAAW
Q9S2A5, LIP1_STRCOQ99156, LIP1_YARLIQ67ZU1, LIP2_ARATH
D4AZ78, LIP2_ARTBCQ9P8W5, LIP2_CANAXP32946, LIP2_DIURU
P22394, LIP2_GEOCNP24484, LIP2_MORS1Q2G155, LIP2_STAA8
Q5HJ48, LIP2_STAACQ99WQ6, LIP2_STAAMQ7A7P2, LIP2_STAAN
Q6GJZ6, LIP2_STAARQ6GCF1, LIP2_STAASP10335, LIP2_STAAU
Q8NYC2, LIP2_STAAWQ93J06, LIP2_STRCOD4B1N9, LIP3_ARTBC
Q9P8W2, LIP3_CANAXP32947, LIP3_DIURUP24640, LIP3_MORS1
Q96VC9, LIP3_YARLIQ9P8W1, LIP4_CANALP32948, LIP4_DIURU
Q9P8W0, LIP5_CANALP32949, LIP5_DIURUQ9P4E8, LIP6_CANAL
Q9P4E7, LIP7_CANALQ9P8V9, LIP8_CANALQ9P4E6, LIP9_CANAL
D4AX63, LIPA_ARTBCW3VKA4, LIPA_MOEAPP26504, LIPA_PSEFL
P0CT91, LIPA_SODALP41365, LIPB_PSEA2P41773, LIPB_PSEFL
Q3SZ79, LIPC_BOVINP11150, LIPC_HUMANP27656, LIPC_MOUSE
O46559, LIPC_RABITP07867, LIPC_RATP40600, LIPE_AERHY
J3RZ81, LIPE_CROADQ29458, LIPF_BOVINP80035, LIPF_CANLF
P07098, LIPF_HUMANQ9CPP7, LIPF_MOUSEP04634, LIPF_RAT
Q9Y5X9, LIPG_HUMANQ9WVG5, LIPG_MOUSEQ8VBX1, LIPG_RAT
Q94252, LIPL4_CAEELP50903, LIPP_CAVPOP83629, LIPP_FELCA
P29183, LIPP_HORSEP16233, LIPP_HUMANO88354, LIPP_ICTTR
Q6P8U6, LIPP_MOUSEQ64425, LIPP_MYOCOP00591, LIPP_PIG
Q02157, LIPP_RABITP27657, LIPP_RATA5PK46, LIPR2_BOVIN
P81139, LIPR2_CAVPOP54317, LIPR2_HUMANP17892, LIPR2_MOUSE
Q64424, LIPR2_MYOCOD7EZN2, LIPR2_PIGP54318, LIPR2_RAT
Q17RR3, LIPR3_HUMANP29605, LIPT_BURCEI6Y2J4, LIPY_MYCTU
Q5U780, LIP_BACSPP22088, LIP_BURCEP0DUB8, LIP_BURPL
P26876, LIP_PSEAEP08658, LIP_PSEFRP0DUB9, LIP_PSEPS
P25275, LIP_PSES5P26877, LIP_PSEU0P19515, LIP_RHIMI
P61871, LIP_RHINIP61872, LIP_RHIORP0C0R3, LIP_STAEP
Q5HKP6, LIP_STAEQP0C0R4, LIP_STAESP04635, LIP_STAHY
Q93MW7, LIP_STRRMO59952, LIP_THELAP15493, LIP_VIBCH
Q5VKJ7, OBL1_RICCOP0DX29, PETH1_AMYMSO70320, PLB1_CAVPO
Q6P1J6, PLB1_HUMANQ06HQ7, PLB1_MONDOQ3TTY0, PLB1_MOUSE
Q05017, PLB1_RABITO54728, PLB1_RATQ2KI18, PLPL2_BOVIN
Q11186, PLPL2_CAEELQ96AD5, PLPL2_HUMANQ8BJ56, PLPL2_MOUSE
P0C548, PLPL2_RATQ9NST1, PLPL3_HUMANQ91WW7, PLPL3_MOUSE
P41247, PLPL4_HUMANQ7Z6Z6, PLPL5_HUMANQ32LZ8, PLPL5_MOUSE
Q9M1I6, SDP1L_ARATHQ9LZA6, SDP1_ARATHP54857, TGL2_YEAST
Q9Y7P3, TGL3_SCHPOP40308, TGL3_YEASTO14115, TGL4_SCHPO
P36165, TGL4_YEASTQ9Y827, TGL5_SCHPOQ12043, TGL5_YEAST
Q06522, YP147_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-