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ENZYME

ENZYME entry: EC 3.1.1.3

Accepted Name
triacylglycerol lipase
Alternative Name(s)
lipase
tributyrase
triglyceride lipase
Reaction catalysed
a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)
Comment(s)
  • The enzyme is found in diverse organisms including animals, plants, fungi, and bacteria.
  • It hydrolyzes triglycerides into diglycerides and subsequently into monoglycerides and free fatty acids.
  • The enzyme is highly soluble in water and acts at the surface of oil droplets.
  • Access to the active site is controlled by the opening of a lid, which, when closed, hides the hydrophobic surface that surrounds the active site.
  • The lid opens when the enzyme contacts an oil-water interface (interfacial activation).
  • The pancreatic enzyme requires a protein cofactor, namely colipase, to counteract the inhibitory effects of bile salts.
Cross-references
BRENDA3.1.1.3
EC2PDB3.1.1.3
ExplorEnz3.1.1.3
PRIAM enzyme-specific profiles3.1.1.3
KEGG Ligand Database for Enzyme Nomenclature3.1.1.3
IUBMB Enzyme Nomenclature3.1.1.3
IntEnz3.1.1.3
MEDLINEFind literature relating to 3.1.1.3
MetaCyc3.1.1.3
Rhea expert-curated reactions3.1.1.3
UniProtKB/Swiss-Prot
Q0P5B7, AAAD_BOVINP22760, AAAD_HUMANQ99PG0, AAAD_MOUSE
Q7M370, AAAD_RABITQ9QZH8, AAAD_RATQ0V1P1, AT151_PHANO
A6REI4, ATG15_AJECNA1C6D6, ATG15_ASPCLQ4X180, ATG15_ASPFU
A2QGD9, ATG15_ASPNCQ0CXU6, ATG15_ASPTNQ5A4N0, ATG15_CANAL
Q6FPI6, ATG15_CANGAQ2H6M8, ATG15_CHAGBQ1DZE0, ATG15_COCIM
P0CO61, ATG15_CRYNBP0CO60, ATG15_CRYNJQ6BLM0, ATG15_DEBHA
Q5B0L1, ATG15_EMENIQ75EN3, ATG15_EREGSI1RFN8, ATG15_GIBZE
Q6CU02, ATG15_KLULAA5E567, ATG15_LODELA1DH10, ATG15_NEOFI
Q7RYY1, ATG15_NEUCRO13444, ATG15_PASFUA7KAM5, ATG15_PENRW
A7KAJ9, ATG15_PICANA5DC90, ATG15_PICGUA3LV34, ATG15_PICST
O13934, ATG15_SCHPOQ4PHZ2, ATG15_USTMAA7TG13, ATG15_VANPO
Q6C2N7, ATG15_YARLIA6ZTP2, ATG15_YEAS7P25641, ATG15_YEAST
Q09851, AYR1_SCHPOP40471, AYR1_YEASTP30122, CEL_BOVIN
P19835, CEL_HUMANQ64285, CEL_MOUSEP07882, CEL_RAT
O94830, DDHD2_HUMANQ80Y98, DDHD2_MOUSEQ8NCG7, DGLB_HUMAN
Q91WC9, DGLB_MOUSEP0C1S9, DGLB_RATP37957, ESTA_BACSU
Q79F14, ESTB_BACSUP38139, LDH1_YEASTP47145, LIH1_YEAST
Q9P4E5, LIP10_CANALQ71DJ5, LIP1_ARATHD4ASH1, LIP1_ARTBC
O94091, LIP1_CANALP79066, LIP1_DIPFEP20261, LIP1_DIURU
P17573, LIP1_GEOCNI1RDA9, LIP1_GIBZEQ2VG90, LIP1_MALFU
P19833, LIP1_MORS1P40601, LIP1_PHOLUQ02104, LIP1_PSYIM
Q2FUU5, LIP1_STAA8Q5HCM7, LIP1_STAACP65288, LIP1_STAAM
P65289, LIP1_STAANQ6GDD3, LIP1_STAARQ6G604, LIP1_STAAS
Q8NUI5, LIP1_STAAWQ9S2A5, LIP1_STRCOQ99156, LIP1_YARLI
Q67ZU1, LIP2_ARATHD4AZ78, LIP2_ARTBCQ9P8W5, LIP2_CANAL
P32946, LIP2_DIURUP22394, LIP2_GEOCNE1CJK0, LIP2_MALFU
A8QCW4, LIP2_MALGOP24484, LIP2_MORS1Q2G155, LIP2_STAA8
Q5HJ48, LIP2_STAACQ99WQ6, LIP2_STAAMQ7A7P2, LIP2_STAAN
Q6GJZ6, LIP2_STAARQ6GCF1, LIP2_STAASP10335, LIP2_STAAU
Q8NYC2, LIP2_STAAWQ93J06, LIP2_STRCOD4B1N9, LIP3_ARTBC
Q9P8W2, LIP3_CANALP32947, LIP3_DIURUE1CJK1, LIP3_MALFU
A8QDF0, LIP3_MALGOA0A0K0VEZ4, LIP3_MALR7A0A8R9YZM7, LIP3_MALRS
P24640, LIP3_MORS1Q96VC9, LIP3_YARLIQ9P8W1, LIP4_CANAL
P32948, LIP4_DIURUE1CJK2, LIP4_MALFUA8PX35, LIP4_MALGO
Q9P8W0, LIP5_CANALP32949, LIP5_DIURUD9N4H3, LIP5_MALFU
A8QCV7, LIP5_MALGOA0A3G2S5J6, LIP5_MALR7A0A8R9YVA6, LIP5_MALRS
Q9P4E8, LIP6_CANALD9N4H4, LIP6_MALFUA8Q9M3, LIP6_MALGO
Q9P4E7, LIP7_CANALA8QCV4, LIP7_MALGOQ9P8V9, LIP8_CANAL
Q9P4E6, LIP9_CANALD4AX63, LIPA_ARTBCW3VKA4, LIPA_MOEAP
Q9P451, LIPA_PENCYP26504, LIPA_PSEFLP0CT91, LIPA_SODAL
P41365, LIPB_PSEA2P41773, LIPB_PSEFLQ3SZ79, LIPC_BOVIN
P11150, LIPC_HUMANP27656, LIPC_MOUSEO46559, LIPC_RABIT
P07867, LIPC_RATP40600, LIPE_AERHYJ3RZ81, LIPE_CROAD
Q29458, LIPF_BOVINP80035, LIPF_CANLFP07098, LIPF_HUMAN
Q9CPP7, LIPF_MOUSEP04634, LIPF_RATQ9Y5X9, LIPG_HUMAN
Q9WVG5, LIPG_MOUSEQ8VBX1, LIPG_RATQ94252, LIPL4_CAEEL
P50903, LIPP_CAVPOP83629, LIPP_FELCAP29183, LIPP_HORSE
P16233, LIPP_HUMANO88354, LIPP_ICTTRQ6P8U6, LIPP_MOUSE
Q64425, LIPP_MYOCOP00591, LIPP_PIGQ02157, LIPP_RABIT
P27657, LIPP_RATA5PK46, LIPR2_BOVINP81139, LIPR2_CAVPO
P54317, LIPR2_HUMANP17892, LIPR2_MOUSEQ64424, LIPR2_MYOCO
D7EZN2, LIPR2_PIGP54318, LIPR2_RATQ17RR3, LIPR3_HUMAN
P29605, LIPT_BURCEI6Y2J4, LIPY_MYCTUQ5U780, LIP_BACSP
P22088, LIP_BURCEP0DUB8, LIP_BURPLP26876, LIP_PSEAE
P08658, LIP_PSEFRP0DUB9, LIP_PSEPSP25275, LIP_PSES5
P26877, LIP_PSEU0P19515, LIP_RHIMIP61871, LIP_RHINI
P61872, LIP_RHIORP0C0R3, LIP_STAEPQ5HKP6, LIP_STAEQ
P0C0R4, LIP_STAESP04635, LIP_STAHYQ93MW7, LIP_STRRM
O59952, LIP_THELAP15493, LIP_VIBCHQ5VKJ7, OBL1_RICCO
P0DX29, PETH1_AMYMSO70320, PLB1_CAVPOQ6P1J6, PLB1_HUMAN
Q06HQ7, PLB1_MONDOQ3TTY0, PLB1_MOUSEQ05017, PLB1_RABIT
O54728, PLB1_RATQ2KI18, PLPL2_BOVINQ11186, PLPL2_CAEEL
Q96AD5, PLPL2_HUMANQ8BJ56, PLPL2_MOUSEP0C548, PLPL2_RAT
Q9NST1, PLPL3_HUMANQ91WW7, PLPL3_MOUSEP41247, PLPL4_HUMAN
Q7Z6Z6, PLPL5_HUMANQ32LZ8, PLPL5_MOUSEQ9M1I6, SDP1L_ARATH
Q9LZA6, SDP1_ARATHP54857, TGL2_YEASTQ9Y7P3, TGL3_SCHPO
P40308, TGL3_YEASTO14115, TGL4_SCHPOP36165, TGL4_YEAST
Q9Y827, TGL5_SCHPOQ12043, TGL5_YEASTQ06522, YP147_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-