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ENZYME entry: EC 3.1.1.3

Accepted Name
Triacylglycerol lipase.
Alternative Name(s)
Lipase.
Tributyrase.
Triglyceride lipase.
Reaction catalysed
Triacylglycerol + H(2)O <=> diacylglycerol + a carboxylate
Comment(s)
  • The enzyme is found in diverse organisms including animals, plants, fungi, and bacteria.
  • It hydrolyzes triglycerides into diglycerides and subsequently into monoglycerides and free fatty acids.
  • The enzyme is highly soluble in water and acts at the surface of oil droplets.
  • Access to the active site is controlled by the opening of a lid, which, when closed, hides the hydrophobic surface that surrounds the active site.
  • The lid opens when the enzyme contacts an oil-water interface (interfacial activation).
  • The pancreatic enzyme requires a protein cofactor, namely colipase, to counteract the inhibitory effects of bile salts.
Cross-references
PROSITEPDOC00110 ; PDOC00112
BRENDA3.1.1.3
EC2PDB3.1.1.3
ExplorEnz3.1.1.3
PRIAM enzyme-specific profiles3.1.1.3
KEGG Ligand Database for Enzyme Nomenclature3.1.1.3
IUBMB Enzyme Nomenclature3.1.1.3
IntEnz3.1.1.3
MEDLINEFind literature relating to 3.1.1.3
MetaCyc3.1.1.3
Rhea expert-curated reactions3.1.1.3
UniProtKB/Swiss-Prot
Q0P5B7, AAAD_BOVIN;  P22760, AAAD_HUMAN;  Q99PG0, AAAD_MOUSE;  
Q7M370, AAAD_RABIT;  Q9QZH8, AAAD_RAT;  Q0V1P1, AT151_PHANO;  
A6REI4, ATG15_AJECN;  Q75EN3, ATG15_ASHGO;  A1C6D6, ATG15_ASPCL;  
Q4X180, ATG15_ASPFU;  A2QGD9, ATG15_ASPNC;  Q0CXU6, ATG15_ASPTN;  
Q5A4N0, ATG15_CANAL;  Q6FPI6, ATG15_CANGA;  Q2H6M8, ATG15_CHAGB;  
Q1DZE0, ATG15_COCIM;  P0CO61, ATG15_CRYNB;  P0CO60, ATG15_CRYNJ;  
Q6BLM0, ATG15_DEBHA;  Q5B0L1, ATG15_EMENI;  I1RFN8, ATG15_GIBZE;  
Q6CU02, ATG15_KLULA;  A5E567, ATG15_LODEL;  A1DH10, ATG15_NEOFI;  
Q7RYY1, ATG15_NEUCR;  O13444, ATG15_PASFU;  A7KAM5, ATG15_PENRW;  
A7KAJ9, ATG15_PICAN;  A5DC90, ATG15_PICGU;  A3LV34, ATG15_PICST;  
O13934, ATG15_SCHPO;  Q4PHZ2, ATG15_USTMA;  A7TG13, ATG15_VANPO;  
Q6C2N7, ATG15_YARLI;  A6ZTP2, ATG15_YEAS7;  P25641, ATG15_YEAST;  
Q09851, AYR1_SCHPO;  P40471, AYR1_YEAST;  P30122, CEL_BOVIN;  
P19835, CEL_HUMAN;  Q64285, CEL_MOUSE;  P07882, CEL_RAT;  
Q8NCG7, DGLB_HUMAN;  Q91WC9, DGLB_MOUSE;  P0C1S9, DGLB_RAT;  
P37957, ESTA_BACSU;  Q79F14, ESTB_BACSU;  P38139, LDH1_YEAST;  
P47145, LIH1_YEAST;  Q9P4E5, LIP10_CANAL;  Q71DJ5, LIP1_ARATH;  
D4ASH1, LIP1_ARTBC;  O94091, LIP1_CANAX;  P20261, LIP1_DIURU;  
P17573, LIP1_GEOCN;  P79066, LIP1_GEOFE;  P19833, LIP1_MORS1;  
P40601, LIP1_PHOLU;  Q02104, LIP1_PSYIM;  Q2FUU5, LIP1_STAA8;  
Q5HCM7, LIP1_STAAC;  P65288, LIP1_STAAM;  P65289, LIP1_STAAN;  
Q6GDD3, LIP1_STAAR;  Q6G604, LIP1_STAAS;  Q8NUI5, LIP1_STAAW;  
Q9S2A5, LIP1_STRCO;  Q99156, LIP1_YARLI;  Q67ZU1, LIP2_ARATH;  
D4AZ78, LIP2_ARTBC;  Q9P8W5, LIP2_CANAX;  P32946, LIP2_DIURU;  
P22394, LIP2_GEOCN;  P24484, LIP2_MORS1;  Q2G155, LIP2_STAA8;  
Q5HJ48, LIP2_STAAC;  Q99WQ6, LIP2_STAAM;  Q7A7P2, LIP2_STAAN;  
Q6GJZ6, LIP2_STAAR;  Q6GCF1, LIP2_STAAS;  P10335, LIP2_STAAU;  
Q8NYC2, LIP2_STAAW;  Q93J06, LIP2_STRCO;  D4B1N9, LIP3_ARTBC;  
Q9P8W2, LIP3_CANAX;  P32947, LIP3_DIURU;  P24640, LIP3_MORS1;  
Q96VC9, LIP3_YARLI;  Q9P8W1, LIP4_CANAL;  P32948, LIP4_DIURU;  
Q9P8W0, LIP5_CANAL;  P32949, LIP5_DIURU;  Q9P4E8, LIP6_CANAL;  
Q9P4E7, LIP7_CANAL;  Q9P8V9, LIP8_CANAL;  Q9P4E6, LIP9_CANAL;  
D4AX63, LIPA_ARTBC;  W3VKA4, LIPA_PSEA5;  P26504, LIPA_PSEFL;  
P0CT91, LIPA_SODAL;  P41365, LIPB_PSEA2;  P41773, LIPB_PSEFL;  
Q3SZ79, LIPC_BOVIN;  P11150, LIPC_HUMAN;  P27656, LIPC_MOUSE;  
O46559, LIPC_RABIT;  P07867, LIPC_RAT;  P40600, LIPE_AERHY;  
J3RZ81, LIPE_CROAD;  Q9Y5X9, LIPE_HUMAN;  Q9WVG5, LIPE_MOUSE;  
Q8VBX1, LIPE_RAT;  Q29458, LIPG_BOVIN;  P80035, LIPG_CANLF;  
P07098, LIPG_HUMAN;  Q9CPP7, LIPG_MOUSE;  P04634, LIPG_RAT;  
Q94252, LIPL4_CAEEL;  P50903, LIPP_CAVPO;  P83629, LIPP_FELCA;  
P29183, LIPP_HORSE;  P16233, LIPP_HUMAN;  O88354, LIPP_ICTTR;  
Q6P8U6, LIPP_MOUSE;  Q64425, LIPP_MYOCO;  P00591, LIPP_PIG;  
Q02157, LIPP_RABIT;  P27657, LIPP_RAT;  A5PK46, LIPR2_BOVIN;  
P81139, LIPR2_CAVPO;  P54317, LIPR2_HUMAN;  P17892, LIPR2_MOUSE;  
Q64424, LIPR2_MYOCO;  D7EZN2, LIPR2_PIG;  P54318, LIPR2_RAT;  
Q17RR3, LIPR3_HUMAN;  P29605, LIPT_BURCE;  I6Y2J4, LIPY_MYCTU;  
Q5U780, LIP_BACSP;  P22088, LIP_BURCE;  P0DUB8, LIP_BURPL;  
P26876, LIP_PSEAE;  P08658, LIP_PSEFR;  P0DUB9, LIP_PSEPS;  
P25275, LIP_PSES5;  P26877, LIP_PSEU0;  P19515, LIP_RHIMI;  
P61871, LIP_RHINI;  P61872, LIP_RHIOR;  P0C0R3, LIP_STAEP;  
Q5HKP6, LIP_STAEQ;  P0C0R4, LIP_STAES;  P04635, LIP_STAHY;  
Q93MW7, LIP_STRRM;  O59952, LIP_THELA;  P15493, LIP_VIBCH;  
Q5VKJ7, OBL1_RICCO;  O70320, PLB1_CAVPO;  Q6P1J6, PLB1_HUMAN;  
Q06HQ7, PLB1_MONDO;  Q3TTY0, PLB1_MOUSE;  Q05017, PLB1_RABIT;  
O54728, PLB1_RAT;  Q2KI18, PLPL2_BOVIN;  Q11186, PLPL2_CAEEL;  
Q96AD5, PLPL2_HUMAN;  Q8BJ56, PLPL2_MOUSE;  P0C548, PLPL2_RAT;  
Q9NST1, PLPL3_HUMAN;  Q91WW7, PLPL3_MOUSE;  P41247, PLPL4_HUMAN;  
Q7Z6Z6, PLPL5_HUMAN;  Q32LZ8, PLPL5_MOUSE;  Q9M1I6, SDP1L_ARATH;  
Q9LZA6, SDP1_ARATH;  P54857, TGL2_YEAST;  Q9Y7P3, TGL3_SCHPO;  
P40308, TGL3_YEAST;  O14115, TGL4_SCHPO;  P36165, TGL4_YEAST;  
Q9Y827, TGL5_SCHPO;  Q12043, TGL5_YEAST;  Q06522, YP147_YEAST;  

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