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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.1.1.57

Accepted Name
2-pyrone-4,6-dicarboxylate lactonase.
Alternative Name(s)
2-pyrone-4,6-dicarboxylate hydrolase.
2-pyrone-4,6-dicarboxylate lactonohydrolase.
Reaction catalysed
2-oxo-2H-pyran-4,6-dicarboxylate + H(2)O <=> (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate
Comment(s)
  • The product is most likely the keto-form of 4-oxalmesaconate (shown).
  • It can be converted to the enol-form, 4-hydroxybuta-1,3-diene-1,2,4- trioate, either spontaneously or by EC 5.3.2.8.
Cross-references
BRENDA3.1.1.57
EC2PDB3.1.1.57
ExplorEnz3.1.1.57
PRIAM enzyme-specific profiles3.1.1.57
KEGG Ligand Database for Enzyme Nomenclature3.1.1.57
IUBMB Enzyme Nomenclature3.1.1.57
IntEnz3.1.1.57
MEDLINEFind literature relating to 3.1.1.57
MetaCyc3.1.1.57
UniProtKB/Swiss-Prot
Q93PS7, LIGI_COMTE;  O87170, LIGI_SPHSK;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-