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ENZYME

ENZYME entry: EC 3.1.1.64

Accepted Name
retinoid isomerohydrolase
Alternative Name(s)
all-trans-retinylester 11-cis isomerohydrolase
all-trans-retinyl-palmitate hydrolase
Reaction catalysed
an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)
Comment(s)
  • This enzyme, which operates in the retinal pigment epithelium (RPE), catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol, a key step in the regeneration of the visual chromophore in the vertebrate visual cycle.
  • Interaction of the enzyme with the membrane is critical for its enzymatic activity.
  • Formerly EC 5.2.1.7.
Cross-references
BRENDA3.1.1.64
EC2PDB3.1.1.64
ExplorEnz3.1.1.64
PRIAM enzyme-specific profiles3.1.1.64
KEGG Ligand Database for Enzyme Nomenclature3.1.1.64
IUBMB Enzyme Nomenclature3.1.1.64
IntEnz3.1.1.64
MEDLINEFind literature relating to 3.1.1.64
MetaCyc3.1.1.64
Rhea expert-curated reactions3.1.1.64
UniProtKB/Swiss-Prot
Q6PBW5, RP65A_DANREA9C3R8, RP65C_DANREQ9YI25, RPE65_AMBTI
Q28175, RPE65_BOVINQ9TVB8, RPE65_CANLFQ9YGX2, RPE65_CHICK
Q9XT71, RPE65_CHLAEQ8AXN9, RPE65_CYNPYQ16518, RPE65_HUMAN
Q91ZQ5, RPE65_MOUSEO70276, RPE65_RAT

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